{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:52:01Z","timestamp":1772913121408,"version":"3.50.1"},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The goal of this study was to evaluate gene delivery to a benign brain tumor.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> A recombinant adenovirus vector bearing the <jats:italic>Escherichia coli<\/jats:italic> \u03b2-<jats:italic>galactosidase<\/jats:italic> reporter gene was selectively injected into the vascular supply of a spontaneously occurring canine olfactory groove meningioma. The tumor and a small amount of peritumoral brain tissue were removed 5 days after viral injection and stained with X-Gal to assess gene delivery. The authors noted significant \u03b2-<jats:italic>galactosidase<\/jats:italic> gene expression by the tumor, but not by surrounding brain tissue. No obvious viral-related cytotoxicity was noted.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> The authors found that meningiomas can be successfully transduced by adenovirus vectors by using endovascular techniques.<\/jats:p>","DOI":"10.3171\/jns.1998.88.5.0870","type":"journal-article","created":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T02:13:55Z","timestamp":1245118435000},"page":"870-873","source":"Crossref","is-referenced-by-count":22,"title":["Selective intraarterial gene delivery into a canine meningioma"],"prefix":"10.3171","volume":"88","author":[{"given":"Anne E.","family":"Chauvet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhakar P.","family":"Kesava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chern Sing","family":"Goh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam","family":"Badie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199411000-00016"},{"key":"b2","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1073\/pnas.91.8.3054","volume":"91","author":"Chen SH","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"b3","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.1317968","volume":"256","author":"Culver KW","year":"1992","journal-title":"Science"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1996.7.10-1241"},{"key":"b5","first-page":"1679","volume-title":"Fields Virology","author":"Horowitz M","year":"1990","edition":"2"},{"key":"b6","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1126\/science.8382374","volume":"259","author":"Le Gal La Salle G","year":"1993","journal-title":"Science"},{"key":"b7","first-page":"1840","volume":"147","author":"Muldoon LL","year":"1995","journal-title":"Am J Pathol"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.82.1.0070"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199412000-00012"},{"key":"b10","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1073\/pnas.91.10.4407","volume":"91","author":"Yang Y","year":"1994","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/88\/5\/article-p870.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/88\/5\/article-p870.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/88\/5\/article-p870.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T03:49:29Z","timestamp":1653709769000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/88\/5\/article-p870.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":10,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1998.88.5.0870","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}