{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T05:24:08Z","timestamp":1668317048392},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The high-affinity growth hormone\u2014binding protein (GHBP) represents the extracellular portion of the growth hormone (GH) receptor, and its serum levels are a reflection of the tissue receptor status. Levels of GHBP are decreased in patients with active acromegaly, probably because of downregulation of GH receptors. However, there are no studies of patients with acromegaly in which the effects of medical (that is, administration of somatostatin analogs) and surgical therapy on GHBP levels have been compared. That is the task the authors set out to accomplish in this study.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> The authors studied seven patients in whom acromegaly had been recently diagnosed. They examined these patients at baseline, 2 months after octreotide treatment (subcutaneous administration of 100 \u00b5g octreotide three times per day), and 1 month after transsphenoidal surgery. Growth hormone\u2014binding activity was measured, as well as the following biochemical markers of the somatotropic axis: GH suppression induced by oral administration of glucose, insulin-like growth factor-I (IGF-I), and insulin-like growth factor\u2014binding protein-3 (IGFBP3). Although octreotide treatment induced a decrease in the levels of GH, IGF-I, and IGFBP3, as well as an increase in the level of GHBP, these biochemical markers did not reach normal levels. On the other hand, after transsphenoidal surgery, GHBP levels became normal, particularly in those patients in whom serum GH could be suppressed to an undetectable level after glucose loading.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> The authors conclude that persistently low GHBP levels in patients with acromegaly are normalized by successful pituitary surgery and correlate well with disease activity.<\/jats:p>","DOI":"10.3171\/jns.1999.90.4.0647","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:20:04Z","timestamp":1242235204000},"page":"647-650","source":"Crossref","is-referenced-by-count":1,"title":["Differential effects of octreotide treatment and transsphenoidal surgery on growth hormone\u2014binding protein levels in patients with acromegaly"],"prefix":"10.3171","volume":"90","author":[{"given":"Irma","family":"Hernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Soderlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Laura","family":"Espinosa-de-los-Monteros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Zarate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Mercado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Horm Res","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1159\/000182313","article-title":"Growth hormone-binding protein in patients with acromegaly.","volume":"37","author":"Amit","year":"1992"},{"key":"b2","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1210\/jcem-56-5-946","article-title":"The molecular nature of circulating growth hormone in normal and acromegalic man: evidence for a principal and minor monomeric forms.","volume":"56","author":"Baumann","year":"1983"},{"key":"b3","series-title":"Nutrition","first-page":"546","article-title":"Growth hormone-binding proteins in plasma.","volume":"9","author":"Baumann","year":"1994"},{"key":"b4","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1210\/jcem-62-1-134","article-title":"A specific growth hormone binding protein in human plasma: initial characterization.","volume":"62","author":"Baumann","year":"1986"},{"key":"b5","series-title":"Eur J Endocrinol","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1530\/eje.0.1360061","article-title":"Growth hormone binding protein and growth hormone availability in acromegalic patients treated with long-acting octreotide (Sandostatin-LAR).","volume":"136","author":"Fisker","year":"1997"},{"key":"b6","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"173","DOI":"10.7326\/0003-4819-112-3-173","article-title":"Therapeutic efficacy of the somatostatin analog SMS 201\u2013995 (octreotide) in acromegaly. Effect of dose and frequency and long-term safety.","volume":"112","author":"Ho","year":"1990"},{"key":"b7","series-title":"Acta Endocrinol","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1530\/acta.0.1250023","article-title":"The effect of human growth hormone therapy on GH binding protein in GH-deficient children.","volume":"125","author":"Hochberg","year":"1991"},{"key":"b8","series-title":"J Clin Endocrinol Metab","first-page":"1575","article-title":"The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender.","volume":"81","author":"Johannsson","year":"1996"},{"key":"b9","series-title":"Eur J Endocrinol","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1530\/eje.0.1320306","article-title":"Growth hormone-binding protein-related immunoreactivity in the serum of patients with acromegaly is regulated inversely by growth hormone concentration.","volume":"132","author":"Kratzsch","year":"1995"},{"key":"b10","series-title":"Nature","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/330537a0","article-title":"Growth hormone receptor and serum binding protein: purification, cloning and expression.","volume":"330","author":"Leung","year":"1987"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3171\/jns.1989.70.4.0561","article-title":"Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegaly.","volume":"70","author":"Losa","year":"1989"},{"key":"b12","series-title":"Acta Endocrinol","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1530\/acta.0.1120547","article-title":"Circulating growth hormone forms in Type I diabetic subjects: comparison with normal subjects and acromegalics.","volume":"112","author":"MacFarlane","year":"1986"},{"key":"b13","series-title":"Endocrinology","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1210\/endo-123-2-1053","article-title":"Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C\/insulin-like growth factor I and liver GH receptors in hypophysectomized rats.","volume":"123","author":"Maiter","year":"1988"},{"key":"b14","series-title":"J Clin Endocrinol Metab","first-page":"1464","article-title":"Serum growth hormone (GH)-binding protein\/receptor: an important determinant of GH responsiveness.","volume":"75","author":"Martha","year":"1992"},{"key":"b15","series-title":"Endocrinologist","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/00019616-199307000-00007","article-title":"Growth hormone binding proteins.","volume":"3","author":"Mercado","year":"1993"},{"key":"b16","series-title":"J Clin Endocrinol Metab","first-page":"1291","article-title":"Growth hormone-binding protein determination in plasma: a comparison of immunofunctional and growth hormone-binding assays.","volume":"76","author":"Mercado","year":"1993"},{"key":"b17","series-title":"Clin Endocrinol","first-page":"373","article-title":"High affinity growth hormone binding protein in plasma of patients with acromegaly and the effect of octreotide treatment.","volume":"37","author":"Roelen","year":"1991"},{"key":"b18","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1210\/jcem-61-6-1185","article-title":"Acromegaly: biochemical assessment of cure after long term follow-up of transsphenoidal selective adenomectomy.","volume":"61","author":"Serri","year":"1985"},{"key":"b19","series-title":"Arch Intern Med","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1001\/archinte.1991.00400080073013","article-title":"Long-term treatment of 189 acromegalic patients with the somatostatin analog octreotide. Results of the International Multicenter Acromegaly Study Group.","volume":"151","author":"Vance","year":"1991"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/90\/4\/article-p647.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/90\/4\/article-p647.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/90\/4\/article-p647.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T02:40:15Z","timestamp":1668307215000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/90\/4\/article-p647.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":19,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/jns.1999.90.4.0647","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}