{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:04:54Z","timestamp":1773925494329,"version":"3.50.1"},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> Transsphenoidal surgery is the usual treatment of choice for adrenocorticotropic hormone\u2014secreting pituitary adenomas associated with Cushing's disease. In this paper the authors investigate the complications of transsphenoidal surgery in the treatment of a contemporary series of patients with Cushing's disease.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Between January 1992 and December 1997, 105 patients with Cushing's disease underwent transsphenoidal surgery at the University of Virginia Health Sciences Center. A retrospective analysis of the complications was conducted, and the mortality rate was found to be 0.9% and permanent morbidity was 1.8%. The overall number of complications was 14 (13.3%), which included seven complications directly related to surgery; one instance of permanent diabetes insipidus; one syndrome of inappropriate secretion of antidiuretic hormone; and five medical complications (four patients developed deep vein thrombosis and one developed pneumonia).<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> Transsphenoidal surgery for Cushing's disease has a higher complication rate than that for pituitary adenomas in general. This is primarily related to a greater number of medical complications, most notably deep vein thrombosis, resulting from the generally debilitated state of most patients with Cushing's disease. In view of the high incidence of deep vein thrombosis in these patients, prophylaxis for thromboembolism during the perioperative period is recommended.<\/jats:p>","DOI":"10.3171\/jns.1999.91.2.0175","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:20:59Z","timestamp":1242235259000},"page":"175-179","source":"Crossref","is-referenced-by-count":164,"title":["Complications in a contemporary series of patients who underwent transsphenoidal surgery for Cushing's disease"],"prefix":"10.3171","volume":"91","author":[{"given":"Patrick L.","family":"Semple","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Laws","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1227\/00006123-199007000-00008","article-title":"Loss of vision after transsphenoidal surgery.","volume":"27","author":"Barrow","year":"1990"},{"key":"b2","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1227\/00006123-198706000-00017","article-title":"Incidence and management of complications of transsphenoidal operation for pituitary adenomas.","volume":"20","author":"Black","year":"1987"},{"key":"b3","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/00006123-199702000-00001","article-title":"Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience.","volume":"40","author":"Ciric","year":"1997"},{"key":"b4","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1056\/NEJM198407053110107","article-title":"Inappropriate secretion of antidiuretic hormone after transsphenoidal surgery for pituitary tumors.","volume":"311","author":"Cusick","year":"1984"},{"key":"b5","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3109\/02688699308995072","article-title":"Antibiotic prophylaxis in unrepaired CSF fistulae.","volume":"7","author":"Eljamel","year":"1993"},{"key":"b6","series-title":"J R Soc Med","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1177\/014107688607900504","article-title":"Transsphenoidal surgery for Cushing's disease.","volume":"79","author":"Fahlbusch","year":"1986"},{"key":"b7","series-title":"Clin Inf Dis","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/clinids\/18.4.553","article-title":"Gram-negative meningitis associated with transsphenoidal surgery: case reports and review.","volume":"18","author":"Haile-Mariam","year":"1994"},{"key":"b8","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1227\/00006123-199402000-00012","article-title":"Venous thromboembolism in neurosurgery and neurology patients: a review.","volume":"34","author":"Hamilton","year":"1994"},{"key":"b9","series-title":"Pituitary Adenomas: From Basic Research to Diagnosic and Therapy.","first-page":"255","article-title":"Disturbances of osmoregulation in the neurosurgical setting\u2014with special emphasis on the situation after surgery for pituitary tumors","author":"Hensen","year":"1996"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3171\/jns.1995.83.2.0363","article-title":"Delayed hyponatremia after transsphenoidal surgery for pituitary adenoma. 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