{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:40:54Z","timestamp":1771069254227,"version":"3.50.1"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Enlargement of preexisting pituitary adenomas during pregnancy is well documented, but this phenomenon is unusual for nonendocrine pituitary tumors such as craniopharyngiomas. Only six cases of craniopharyngioma have been reported as presenting during pregnancy.<\/jats:p><jats:p content-type=\"fine-print\">The authors describe a 19-year-old woman who presented with amenorrhea and galactorrhea caused by an intrasellar mass. Seven months later, when she was 20 weeks pregnant, the patient developed sudden visual dysfunction. Emergency transsphenoidal surgery was performed to restore visual function, and the tumor was found to be a craniopharyngioma. The patient had spontaneous labor and delivered a healthy infant at term. The tumor recurred 4 years later, during her second pregnancy, and was again entirely removed via a second transsphenoidal approach. She again had a normal term delivery. During the 5-year follow-up period she has demonstrated no endocrinological or visual dysfunction. Control magnetic resonance images have revealed no recurrence of the tumor. The transsphenoidal approach seems to be the safest procedure to use during pregnancy to achieve an immediate optic nerve decompression and to preserve pituitary function.<\/jats:p>","DOI":"10.3171\/jns.1999.91.2.0322","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:20:59Z","timestamp":1242235259000},"page":"322-324","source":"Crossref","is-referenced-by-count":22,"title":["Rapid enlargement and recurrence of a preexisting intrasellar craniopharyngioma during the course of two pregnancies"],"prefix":"10.3171","volume":"91","author":[{"given":"Yunus","family":"Aydin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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Morphological, immunocytochemical, hormonal and clinical results.","volume":"113","author":"Riedel","year":"1986"},{"key":"b11","series-title":"Br Obstet Gynecol","first-page":"557","article-title":"Rapid enlargement of a craniopharyngioma in pregnancy.","volume":"85","author":"Sachs","year":"1978"},{"key":"b12","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/0090-3019(91)90090-V","article-title":"Secretory component of cystic craniopharyngiomas: a mucino-histochemical and electron-microscopic study.","volume":"36","author":"Szeifert","year":"1991"},{"key":"b13","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/01616412.1993.11740111","article-title":"Could craniopharyngiomas produce pituitary hormones?","volume":"15","author":"Szeifert","year":"1993"},{"key":"b14","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1227\/00006123-199412000-00002","article-title":"Estrogen receptor gene expression in craniopharyngiomas: an in situ hybridization study.","volume":"35","author":"Thapar","year":"1994"},{"key":"b15","series-title":"Eur Obstet Gynecol Reprod Biol","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0028-2243(80)90007-6","article-title":"Diabetes insipidus in pregnancy as a first sign of a craniopharyngioma.","volume":"10","author":"van der Wildt","year":"1980"},{"key":"b16","series-title":"Pituitary Gland.","first-page":"405","article-title":"Recent advances in the diagnosis and treatment of hyperprolactinemia","author":"von Werder","year":"1985"},{"key":"b17","series-title":"Women Health","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1300\/J013v20n02_02","article-title":"The effect of elevated ovarian hormones on periodontal health: oral contraceptives and pregnancy.","volume":"20","author":"Zachariasen","year":"1993"},{"key":"b18","series-title":"Neuroendocrinology","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1159\/000125876","article-title":"Demonstration of insulinlike growth factors I, II and heterogeneous insulin-like growth factor binding proteins in the cyst fluid of patients with craniopharyngioma.","volume":"54","author":"Zumkeller","year":"1991"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/91\/2\/article-p322.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/91\/2\/article-p322.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/91\/2\/article-p322.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T01:43:03Z","timestamp":1679881383000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/91\/2\/article-p322.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":18,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.1999.91.2.0322","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}