{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:22:08Z","timestamp":1792092128931,"version":"4.4.0"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p content-type=\"fine-print\">\n                    <jats:italic>Object.<\/jats:italic>\n                    The increased use of computerized tomography (CT) and magnetic resonance (MR) technology has led to an increase in the detection of asymptomatic meningiomas, although the surgical indication for these tumors remains undetermined. The authors investigated the incidence of asymptomatic meningiomas and their clinical features.\n                  <\/jats:p>\n                  <jats:p content-type=\"fine-print\">\n                    <jats:italic>Methods.<\/jats:italic>\n                    An epidemiological survey was conducted of primary intracranial tumors diagnosed in Kumamoto Prefecture between 1989 and 1996. Follow-up neuroradiological imaging and clinical studies for asymptomatic meningiomas were performed.\n                  <\/jats:p>\n                  <jats:p content-type=\"fine-print\">\n                    Primary intracranial tumors were diagnosed in 1563 residents. Of these lesions, 504 (32.2%) were meningiomas, and of these meningiomas 196 (38.9%) were asymptomatic. The incidence of asymptomatic meningiomas was significantly higher in individuals older than 70 years of age. Furthermore, the incidence of asymptomatic meningiomas was significantly higher in female than in male patients. Of the asymptomatic meningiomas in 196 patients, 87 (44.4%) were surgically removed, whereas 109 (55.6%) were treated conservatively. Of these conservatively treated patients, 63 received follow-up care for more than 1 year. In 20 of these 63 cases, the tumors increased in size over the 27.8-month average follow-up period (range 12\u201387 months), whereas in the other 43 cases, the tumor size did not increase during a 36.6-month average follow-up period (range 12\u201396 months). There was no significant difference with respect to age, tumor size, and male\/female ratio between the patient group in which the tumor size increased and the group in which it did not increase during the follow-up period. Asymptomatic meningiomas that evidenced calcification on CT scans and\/or hypointensity on T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted MR images appear to have a slower growth rate.\n                  <\/jats:p>\n                  <jats:p content-type=\"fine-print\">\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    Among patients older than age 70 years who underwent operation for asymptomatic meningioma, the neurological morbidity rate was 23.3%; it was 3.5% among younger patients. This indicates that the advisability of surgery in elderly patients with asymptomatic meningiomas must be considered very carefully.\n                  <\/jats:p>","DOI":"10.3171\/jns.2000.92.5.0766","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T13:31:38Z","timestamp":1242221498000},"page":"766-770","source":"Crossref","is-referenced-by-count":180,"title":["Incidence and clinical features of asymptomatic meningiomas"],"prefix":"10.3171","volume":"92","author":[{"given":"Jun-ichi","family":"Kuratsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitaka","family":"Ushio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/BF01402612","article-title":"Treatment of intracranial meningiomas in patients over 70 years old.","volume":"107","author":"Arienta","year":"1990"},{"key":"b2","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1227\/00006123-198904000-00011","article-title":"Intracranial meningiomas in the aged: surgical outcome in the era of computed tomography.","volume":"24","author":"Awad","year":"1989"},{"key":"b3","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1136\/jnnp.39.3.290","article-title":"Epidemiology of primary tumours of the brain and spinal cord: a regional survey in southern England.","volume":"39","author":"Barker","year":"1976"},{"key":"b4","series-title":"Neurosurgery","first-page":"1015","article-title":"Magnetic resonance imaging and pathological correlates of meningiomas.","volume":"31","author":"Chen","year":"1992"},{"key":"b5","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/BF01405421","article-title":"Intracranial meningiomas in elderly patients. Postoperative morbidity and mortality. Factors predictive of outcome.","volume":"102","author":"Cornu","year":"1990"},{"key":"b6","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF01560565","article-title":"Intracranial meningiomas in the elderly (over 70 years old). A retrospective study of 30 surgical cases.","volume":"90","author":"Djindjian","year":"1988"},{"key":"b7","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1148\/radiology.170.3.2916043","article-title":"Meningiomas: MR and histopathologic features.","volume":"170","author":"Elster","year":"1989"},{"key":"b8","series-title":"Clin Obstet Gynecol","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/00003081-198709000-00027","article-title":"The role of sonography in pediatric gynecology.","volume":"30","author":"Fleischer","year":"1987"},{"key":"b9","series-title":"J Am Stat Assoc","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations.","volume":"53","author":"Kaplan","year":"1958"},{"key":"b10","series-title":"Brain Pathol","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1750-3639.1993.tb00752.x","article-title":"The new WHO classification of brain tumours.","volume":"3","author":"Kleihues","year":"1993"},{"key":"b11","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1136\/jnnp.63.1.116","article-title":"Epidemiological study of primary intracranial tumours in elderly people.","volume":"63","author":"Kuratsu","year":"1997"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3171\/jns.1996.84.6.0946","article-title":"Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto prefecture in the sourthern part of Japan.","volume":"84","author":"Kuratsu","year":"1996"},{"key":"b13","series-title":"Neuroepidemiology","first-page":"220","article-title":"Epidemiology of primary intracranial neoplasms. Experiment in the Province of Trento (Italy), 1977\u20131984.","volume":"5","author":"Lovaste","year":"1986"},{"key":"b14","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0090-3019(87)90005-X","article-title":"Incidental meningiomas in autopsy study.","volume":"27","author":"Nakasu","year":"1987"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3171\/jns.1995.83.2.0222","article-title":"The natural history and growth rate of asymptomatic meningiomas: a review of 60 patients.","volume":"83","author":"Olivero","year":"1995"},{"key":"b16","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.410370113","article-title":"The trends in incidence of primary brain tumors in the population of Rochester, Minnesota.","volume":"37","author":"Radhakrishnan","year":"1995"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3171\/jns.1989.71.5.0665","article-title":"Incidence and clinicopathological features of meningioma.","volume":"71","author":"Rohringer","year":"1989"},{"key":"b18","series-title":"Neurol Med Chir","doi-asserted-by":"publisher","first-page":"438","DOI":"10.2176\/nmc.35.438","article-title":"Correlation between magnetic resonance images and histology in meningiomas: T2-weighted images indicate collagen contents in tissues.","volume":"35","author":"Soyama","year":"1995"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/92\/5\/article-p766.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/92\/5\/article-p766.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/92\/5\/article-p766.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T01:00:05Z","timestamp":1679878805000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/92\/5\/article-p766.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":18,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.2000.92.5.0766","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}