{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:54:17Z","timestamp":1764996857467},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Acromegaly is usually caused by a growth hormone (GH)-secreting pituitary adenoma, and hypersecretion of GH-releasing hormone (GHRH) from a hypothalamic or neuroendocrine tumor accounts for other cases. The authors report on the unusual association of acromegaly with a granular cell tumor of the neurohypophysis.<\/jats:p><jats:p content-type=\"fine-print\">A 42-year-old woman with a 10-year history of acral enlargement, headache, and menstrual abnormalities was referred to our department for a suspected GH-secreting pituitary adenoma. The patient's basal GH levels were mildly elevated at 4.8 \u00b5g\/L, were not suppressed in response to an oral glucose tolerance test, and increased paradoxically after administration of thyrotropin-releasing hormone. The patient's insulin-like growth factor\u20141 (IGF-1) level was elevated at 462 \u00b5g\/L, whereas a magnetic resonance image of the sella turcica revealed an intra- and suprasellar lesion that was compatible with a diagnosis of pituitary adenoma. A transsphenoidal approach to remove the lesion, which was mainly suprasellar, was successful during a second operative attempt, resulting in the clinical and biochemical regression of the patient's acromegaly. Four months postoperatively, the patient's basal GH level was 0.9 \u00b5g\/L and her IGF-1 level was 140 \u00b5g\/L. Histological analysis of the operative specimen demonstrated a granular cell tumor of the neurohypophysis, which when stained proved negative for pituitary hormones and GHRH.<\/jats:p><jats:p content-type=\"fine-print\">This case represents the first reported association between a granular cell tumor of the neurohypophysis and acromegaly. Granular cell tumor of the neurohypophysis could be added to the restricted list of neoplastic causes of acromegaly secondary to hypersecretion of a GH-releasing substance.<\/jats:p>","DOI":"10.3171\/jns.2000.93.1.0121","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:27:38Z","timestamp":1242235658000},"page":"121-126","source":"Crossref","is-referenced-by-count":24,"title":["Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study"],"prefix":"10.3171","volume":"93","author":[{"given":"Marco","family":"Losa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Saeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Mortini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Pandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosa","family":"Terreni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Taccagni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Giovanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Clin Endocrinol","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1365-2265.1980.tb03135.x","article-title":"Epidemiology of acromegaly in the Newcastle region.","volume":"12","author":"Alexander","year":"1980"},{"key":"b2","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1210\/jcem-58-5-796","article-title":"A case for hypothalamic acromegaly: a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor.","volume":"58","author":"Asa","year":"1984"},{"key":"b3","series-title":"Lancet","first-page":"192","article-title":"Growth hormone release in man induced by galanin, a new hypothalamic peptide.","volume":"2","author":"Bauer","year":"1986"},{"key":"b4","series-title":"Acta Med Scand","first-page":"327","article-title":"Epidemiology and longterm survival in acromegaly. 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