{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:57:50Z","timestamp":1773032270660,"version":"3.50.1"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> For the past 130 years, it has been believed that hypertension-induced cerebral hemorrhages are the result of ruptures of microaneurysms or ruptures of arteries that have degenerative changes. The majority of previous investigations have focused on autopsied brain. In this study, the authors attempted to verify the cause of hypertension-induced cerebral hemorrhage by using surgical specimens of the penetrating arteries responsible for the hemorrhages.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Between 1997 and 1999, the authors performed pathological studies in surgical specimens of lenticulostriate arteries that had been confirmed during microsurgery to be the cause of hypertension-induced hemorrhage of the putamen. Nineteen lenticulostriate arteries were collected from 12 patients. Fifteen of these arteries were verified as the pathological causes of hemorrhage. They included six arterial dissections, six arterial ruptures with substantial degenerative changes, and three arterial ruptures with few degenerative changes. The pathological findings in the lenticulostriate artery dissections were similar to those of typical arterial dissections in major cerebral arteries.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> To the best of the authors' knowledge, arterial dissections of lenticulostriate arteries have not been identified as a cause of hypertension-induced cerebral hemorrhages. When penetrating arteries are included as causative vessels, cerebral arterial dissections may be much more common than previously thought.<\/jats:p>","DOI":"10.3171\/jns.2000.93.5.0859","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:27:13Z","timestamp":1242235633000},"page":"859-862","source":"Crossref","is-referenced-by-count":28,"title":["Arterial dissections of penetrating cerebral arteries causing hypertension-induced cerebral hemorrhage"],"prefix":"10.3171","volume":"93","author":[{"given":"Tohru","family":"Mizutani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Miki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/00005072-199205000-00004","article-title":"The Charcot-Bouchard aneurysm controversy: impact of a new histologic technique.","volume":"51","author":"Challa","year":"1992"},{"key":"b2","series-title":"Arch Physiol Norm Pathol","first-page":"110","article-title":"Nouvelles recherches sur la pathogenie de l'hemorrhagie cerebrale.","volume":"1","author":"Charcot","year":"1868"},{"key":"b3","series-title":"Am J Pathol","first-page":"313","article-title":"Cerebral miliary aneurysms in hypertension.","volume":"66","author":"Fisher","year":"1972"},{"key":"b4","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/00005072-197107000-00015","article-title":"Pathological observations in hypertensive cerebral hemorrhage.","volume":"30","author":"Fisher","year":"1971"},{"key":"b5","series-title":"J Pathol Bacteriol","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/path.1700510206","article-title":"Medial defects in the circle of Willis and their relation to aneurysm formation.","volume":"51","author":"Glynn","year":"1940"},{"key":"b6","series-title":"Nippon Rinsho","first-page":"16","article-title":"[Pathogenesis of medial necrosis as the cause of hypertensive intracerebral hemorrhage.]","volume":"51","author":"Masawa","year":"1993"},{"key":"b7","series-title":"Trans Soc Pathol Jap","first-page":"449","article-title":"Studien \u00fcber Hirnblutung und- erweichung. 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