{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:24:40Z","timestamp":1772915080269,"version":"3.50.1"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 There is a wide variety of disorders associated with thrombosis of the superior sagittal sinus (SSS), including infectious disease, noninfectious conditions such as vasculitis and hypercoagulable states, and complications arising from pregnancy or use of oral contraceptive medications. Despite these well-defined associations, approximately 25% of the cases remain idiopathic. In this article the authors describe a patient who was found to have SSS thrombosis while experiencing a thyrotoxic phase of Graves disease. The patient presented with intracerebral hemorrhage, subarachnoid hemorrhage, seizure, coma, a raised fibrinogen concentration, low protein C activity, and atrial fibrillations. Thrombolysis was successfully performed despite the coexistence of thrombosis and intracranial hemorrhage. Patients with thyrotoxicosis and a diffuse goiter may be predisposed to the development of SSS thrombosis, as a result of hypercoagulation and stasis of local venous blood flow. In the present case, a patient in whom thrombosis coexisted with intracranial hemorrhage was successfully treated using thrombolytic therapy.<\/jats:p>","DOI":"10.3171\/jns.2001.94.1.0130","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:41:45Z","timestamp":1242236505000},"page":"130-132","source":"Crossref","is-referenced-by-count":26,"title":["Superior sagittal sinus thrombosis induced by thyrotoxicosis"],"prefix":"10.3171","volume":"94","author":[{"given":"Cheng-Shyuan","family":"Rau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chung","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Loong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Jung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeh-Lin","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/ana.410030112","article-title":"Primary cerebral venous thrombosis in young adults: the diverse manifestations of an underrecognized disease.","volume":"3","author":"Averback","year":"1978"},{"key":"b2","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1227\/00006123-199101000-00019","article-title":"Direct endovascular thrombolytic therapy for dural sinus thrombosis.","volume":"28","author":"Barnwell","year":"1991"},{"key":"b3","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1161\/01.STR.16.2.199","article-title":"Cerebral venous thrombosis\u2014a review of 38 cases.","volume":"16","author":"Bousser","year":"1985"},{"key":"b4","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1056\/NEJM198605153142006","article-title":"The regulation of hemostasis: the protein C system.","volume":"314","author":"Clouse","year":"1986"},{"key":"b5","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1136\/jnnp.57.5.655","article-title":"Congenital protein C deficiency and superior sagittal sinus thrombosis causing isolated intracranial hypertension.","volume":"57","author":"Confavreux","year":"1994"},{"key":"b6","series-title":"Acta Neurol Scand","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1600-0404.1992.tb05106.x","article-title":"Superior sagittal sinus thrombosis and pulmonary embolism: a syndrome rediscovered.","volume":"86","author":"Diaz","year":"1992"},{"key":"b7","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"956","DOI":"10.7326\/0003-4819-118-12-199306150-00008","article-title":"Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature.","volume":"118","author":"Ernst","year":"1993"},{"key":"b8","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1001\/archneur.1977.00500130022004","article-title":"Superior sagittal sinus thrombosis.","volume":"34","author":"Gettelfinger","year":"1977"},{"key":"b9","series-title":"AJNR","first-page":"S4","article-title":"Direct thrombolytic therapy for superior sagittal sinus thrombosis.","volume":"10","author":"Higashida","year":"1989"},{"key":"b10","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/ana.410380112","article-title":"Treatment of dural sinus thrombosis using selective catheterization and urokinase.","volume":"38","author":"Horowitz","year":"1995"},{"key":"b11","series-title":"Schweiz Med Wochenschr","first-page":"1601","article-title":"A septic cerebral sinus thrombosis: 5 cases and a review.","volume":"121","author":"Horst","year":"1991"},{"key":"b12","series-title":"Can Med Assoc J","first-page":"673","article-title":"Nonvalvular atrial fibrillation: evidence for a prothrombotic state.","volume":"157","author":"Kahn","year":"1997"},{"key":"b13","series-title":"Thromb Haemost","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1055\/s-0038-1642511","article-title":"Factor VII and fibrinogen levels as risk factors for venous thrombosis. A casecontrol study of plasma levels and DNA polymorphism. The Leiden Thrombophilia Study (Lets).","volume":"71","author":"Koster","year":"1994"},{"key":"b14","series-title":"Q J Med","first-page":"155","article-title":"Fibrinogen and cardiovascular disease.","volume":"88","author":"Lip","year":"1995"},{"key":"b15","series-title":"Am Heart J","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S0002-8703(96)90278-1","article-title":"Fibrinogen and fibrin D-dimer levels in paroxysmal atrial fibrillation: evidence for intermediate elevated levels of intravascular thrombogenesis.","volume":"131","author":"Lip","year":"1996"},{"key":"b16","series-title":"AJNR","first-page":"1238","article-title":"Direct thrombolysis of superior sagittal sinus thrombosis coexisting intracranial hemorrhage.","volume":"18","author":"Rael","year":"1997"},{"key":"b17","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1161\/01.STR.26.3.496","article-title":"Superior sagittal sinus thrombosis and thyrotoxicosis: possible association in two cases.","volume":"26","author":"Siegert","year":"1995"},{"key":"b18","series-title":"AJNR","first-page":"801","article-title":"Treatment of dural sinus thrombosis by urokinase infusion.","volume":"15","author":"Smith","year":"1994"},{"key":"b19","series-title":"Medicine","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/00005792-198603000-00002","article-title":"Septic thrombosis of the dural venous sinuses.","volume":"65","author":"Southwick","year":"1986"},{"key":"b20","series-title":"AJNR","first-page":"1137","article-title":"Acute thrombosis of the intracranial dural sinus: direct thrombolytic treatment.","volume":"13","author":"Tsai","year":"1992"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/94\/1\/article-p130.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/94\/1\/article-p130.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/94\/1\/article-p130.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T23:55:40Z","timestamp":1679874940000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/94\/1\/article-p130.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":20,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.2001.94.1.0130","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}