{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:20:55Z","timestamp":1758979255387},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 28-year-old woman presented with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS). The diagnosis was based on the results of molecular genetic analysis, which indicated a typical point mutation at the nucleotide pair 3243. Xenon computerized tomography scans obtained during the strokelike episodes revealed the lesion responsible for the symptoms to be an area of focal hyperperfusion, and scans obtained after the episodes revealed an area of hypoperfusion. Pathogenesis of the strokelike episodes appears to be metabolic dysfunction, although the involvement of a vascular event cannot be excluded.<\/jats:p>","DOI":"10.3171\/jns.2001.94.1.0133","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:41:45Z","timestamp":1242236505000},"page":"133-136","source":"Crossref","is-referenced-by-count":7,"title":["Focal hyperperfusion in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes"],"prefix":"10.3171","volume":"94","author":[{"given":"Kenichi","family":"Amagasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneo","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kakizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"AJNR","first-page":"1234","article-title":"CT and MR of MELAS syndrome.","volume":"9","author":"Allard","year":"1988"},{"key":"b2","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1212\/WNL.46.1.223","article-title":"MELAS: clinical and pathologic correlations with MRI, xenon\/CT, and MR spectroscopy.","volume":"46","author":"Clark","year":"1996"},{"key":"b3","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/ana.410170602","article-title":"Mitochondrial myopathies.","volume":"17","author":"DiMauro","year":"1985"},{"key":"b4","series-title":"J Neurol","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/BF00314013","article-title":"Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy.","volume":"234","author":"Goda","year":"1987"},{"key":"b5","series-title":"Nature","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/348651a0","article-title":"A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.","volume":"348","author":"Goto","year":"1990"},{"key":"b6","series-title":"Biochim Biophys Acta","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/0925-4439(91)90042-8","article-title":"A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).","volume":"1097","author":"Goto","year":"1991"},{"key":"b7","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1161\/01.STR.25.9.1873","article-title":"Cerebral hyperemia in MELAS.","volume":"25","author":"Gropen","year":"1994"},{"key":"b8","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/BF00348922","article-title":"Computed tomography and angiography in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes): report of 3 cases.","volume":"29","author":"Hasuo","year":"1987"},{"key":"b9","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1001\/archneur.1988.00520340032007","article-title":"Hypertensive encephalopathy. 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