{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:43:13Z","timestamp":1789785793810,"version":"4.0.1"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors describe the case of a 57-year-old woman who had a right-sided hearing disturbance that had remained untreated for 1 year. The diagnosis was of a right cerebellopontine angle tumor, and the patient underwent its removal via retrosigmoid approach. Pathologically, the tumor was a typical benign neuroma. Growth of residual tumor was detected 4 years after the initial operation, and it was treated with gamma knife surgery (GKS). Six months later, the tumor had grown, and the patient underwent surgery via a combined retrosigmoid\u2014translabyrinthine approach. Abnormal mitotic figures were observed on histological studies, indicating that the tumor had become malignant. Thereafter, the tumor grew rapidly, and the patient died 6.5 years after the initial treatment. It cannot be ruled out that GKS affected the outcome, but the causal sequence was unclear. Because such a patient is rare, documentation of the case was considered clinically important.<\/jats:p>","DOI":"10.3171\/jns.2001.95.3.0518","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T13:34:25Z","timestamp":1242221665000},"page":"518-521","source":"Crossref","is-referenced-by-count":112,"title":["Acoustic neuroma with malignant transformation"],"prefix":"10.3171","volume":"95","author":[{"given":"Kenichiro","family":"Hanabusa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waro","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Otolaryngol","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/00016488109138503","article-title":"The human acoustic neurinoma in organ culture. II. Tissue changes after gamma irradiation.","volume":"91","author":"Anniko","year":"1981"},{"key":"b2","series-title":"Clin Neuropathol","first-page":"231","article-title":"Epithelioid schwannoma of the acoustic nerve.","volume":"15","author":"Benhaiem-Sigaux","year":"1996"},{"key":"b3","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/BF00688345","article-title":"Malignant triton tumor in the cerebellopontine angle. Report of a case.","volume":"74","author":"Best","year":"1987"},{"key":"b4","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1002\/1097-0142(19850601)55:11<2543::AID-CNCR2820551105>3.0.CO;2-4","article-title":"Malignant \u201ctriton\u201d tumors. Natural history and immunohistochemistry of nine new cases with literature review.","volume":"55","author":"Brooks","year":"1985"},{"key":"b5","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1227\/00006123-199504000-00007","article-title":"Sarcomas subsequent to cranial irradiation.","volume":"36","author":"Chang","year":"1995"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3171\/jns.1998.89.4.0653","article-title":"Death from a malignant cerebellopontine angle triton tumor despite stereotactic radiosurgery. Case report.","volume":"89","author":"Comey","year":"1998"},{"key":"b7","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/S0046-8177(84)80169-0","article-title":"Malignant \u201ctriton\u201d tumors: a clinicopathologic and immunohistochemical study of nine cases.","volume":"15","author":"Daimaru","year":"1984"},{"key":"b8","series-title":"Histopathology","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1111\/j.1365-2559.1985.tb02815.x","article-title":"Epithelioid neurilemoma of the trigeminal nerve: an immunohistochemical and ultrastrucural study.","volume":"9","author":"Franks","year":"1985"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3171\/jns.1992.76.5.0874","article-title":"Malignant triton tumor of the acoustic nerve. Case report.","volume":"76","author":"Han","year":"1992"},{"key":"b10","series-title":"J Pediatr Surg","first-page":"926","article-title":"Malignant schwannoma of facial nerve.","volume":"21","author":"Hasan","year":"1984"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3171\/jns.1978.48.2.0279","article-title":"Primary malignant schwannoma of the gasserian ganglion. Report of two cases.","volume":"48","author":"Hedeman","year":"1978"},{"key":"b12","series-title":"Arch Pathol Lab Med","first-page":"293","article-title":"Malignant nerve sheath tumor of acoustic nerve.","volume":"107","author":"Kudo","year":"1983"},{"key":"b13","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1227\/00006123-198311000-00015","article-title":"Primary malignant nerve sheath tumor of the Gasserian ganglion: a report of two cases.","volume":"13","author":"Levy","year":"1983"},{"key":"b14","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1227\/00006123-199005000-00002","article-title":"Radiosurgery for acoustic neurinomas: early experience.","volume":"26","author":"Linsky","year":"1990"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3171\/jns.1993.78.4.0645","article-title":"The radiobiology of human acoustic schwannoma xenografts after stereotactic radiosurgery evaluated in the subrenal capsule of athymic mice.","volume":"78","author":"Linsky","year":"1993"},{"key":"b16","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3171\/jns.1979.50.2.0253","article-title":"Bilateral trigeminal neurofibrosarcoma. Case report.","volume":"50","author":"Liwnicz","year":"1979"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3171\/jns.1990.73.6.0946","article-title":"Recurrence of acoustic neurilemoma as a malignant spindle-cell neoplasm. Case report.","volume":"73","author":"McLean","year":"1990"},{"key":"b18","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1227\/00006123-198307000-00003","article-title":"Stereotactic radiosurgery in cases of acoustic neurinoma: further experiences.","volume":"13","author":"Nor\u00e9n","year":"1983"},{"key":"b19","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1227\/00006123-199501000-00036","article-title":"Outcome analysis of acoustic neuroma management: a comparison of microsurgery and stereotactic radiosurgery.","volume":"36","author":"Pollock","year":"1995"},{"key":"b20","series-title":"Am J Cancer","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1158\/ajc.1935.751","article-title":"The peripheral manifestations of the specific nerve sheath tumor (neurilemoma).","volume":"24","author":"Stout","year":"1935"},{"key":"b21","series-title":"Lancet","first-page":"81","article-title":"Assessment of coma and impaired consciousness. A practical scale.","volume":"2","author":"Teasdale","year":"1974"},{"key":"b22","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1097\/00000478-199409000-00003","article-title":"Schwannoma (neurilemoma) with malignant transformation. A rare, distinctive peripheral nerve tumor.","volume":"18","author":"Woodruff","year":"1994"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/95\/3\/article-p518.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/95\/3\/article-p518.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/95\/3\/article-p518.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T17:09:31Z","timestamp":1679850571000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/95\/3\/article-p518.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":22,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/jns.2001.95.3.0518","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}