{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:20:12Z","timestamp":1791127212673,"version":"4.1.0"},"reference-count":49,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10]]},"abstract":"Object.<\/jats:italic> The most frequent genetic abnormality in human malignant gliomas is loss of heterozygosity (LOH) on chromosome 10. Candidate genes on chromosome 10 that are associated with the prognosis of patients with anaplastic astrocytoma (AA) and glioblastoma (GBM) were evaluated.<\/jats:p>\nMethods.<\/jats:italic> The authors used 12 fluorescent microsatellite markers on both arms of chromosome 10 to study LOH in 108 primary astrocytic tumors. The LOH on chromosome 10 was observed in 11 (32%) of 34 AAs and 34 (56%) of 61 GBMs. No LOH was detected in 13 low-grade gliomas. Loss of heterozygosity was not detected in any AA in the seven patients younger than 35 years, but it was discovered in 41% of the patients older than 35 years. The prognostic significance of LOH at each locus was evaluated in 89 patients older than 15 years; 33 (37%) had supratentorial AAs and 56 (63%) had supratentorial GBMs. The Cox proportional hazards model, adjusted for patient age at surgery, the preoperative Karnofsky Performance Scale score, and the extent of surgical resection revealed that LOH on marker D10S209 near the FGFR2<\/jats:italic> and DMBT1<\/jats:italic> genes was significantly associated with shorter survival in patients with AA. The LOH on markers D10S215 and D10S541, which contain the PTEN\/MMAC1<\/jats:italic> gene between them, was significantly associated with shorter survival in patients with GBM.<\/jats:p>\nConclusions.<\/jats:italic> In the present study it is found that LOH on chromosome 10 is an age-dependent event for patients with AAs and that LOH on marker D10S209 near the FGFR2<\/jats:italic> and DMBT1<\/jats:italic> loci is a significantly unfavorable prognostic factor. It is also reported that LOH on the PTEN\/MMAC1<\/jats:italic> gene is a significantly unfavorable prognostic factor in patients with GBM.<\/jats:p>","DOI":"10.3171\/jns.2001.95.4.0651","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:34:32Z","timestamp":1242236072000},"page":"651-659","source":"Crossref","is-referenced-by-count":48,"title":["Analysis of loss of heterozygosity for chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival"],"prefix":"10.3171","volume":"95","author":[{"given":"Kenji","family":"Tada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kamiryo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ichi","family":"Kuratsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Saya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitaka","family":"Ushio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Am J Hum Genet","first-page":"1260","article-title":"Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q.","volume":"58","author":"Albarosa","year":"1996"},{"key":"b2","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1227\/00006123-198708000-00012","article-title":"Effect of the extent of surgical resection on survival and quality of life in patients with supratentorial glioblastomas and anaplastic astrocytomas.","volume":"21","author":"Ammirati","year":"1987"},{"key":"b3","series-title":"Br J Cancer","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/sj.bjc.6693403","article-title":"Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas.","volume":"81","author":"Balesaria","year":"1999"},{"key":"b4","series-title":"Cancer Genet Cytogenet","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0165-4608(90)90024-5","article-title":"Cytogenetics of human brain tumors.","volume":"47","author":"Bigner","year":"1990"},{"key":"b5","series-title":"Cancer Res","first-page":"405","article-title":"Specific chromosomal abnormalities in malignant human gliomas.","volume":"48","author":"Bigner","year":"1988"},{"key":"b6","series-title":"Oncogene","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1038\/sj.onc.1202481","article-title":"A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors.","volume":"17","author":"Chernova","year":"1998"},{"key":"b7","series-title":"FASEB J","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1096\/fasebj.7.10.8344489","article-title":"Gene and chromosomal alterations associated with the development of human gliomas.","volume":"7","author":"Collins","year":"1993"},{"key":"b8","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/BF00172709","article-title":"Does extent of surgery influence outcome for astrocytoma with atypical or anaplastic foci (AAF)? 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