{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:22:01Z","timestamp":1776468121639,"version":"3.51.2"},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors present the hospital course of a 13-year-old girl with a closed head injury who received a prolonged infusion of propofol for sedation and, subsequently, died as a result of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse.<\/jats:p>\n<jats:p content-type=\"fine-print\">The patient had been treated for 4 days at a referring hospital for a severe closed head injury sustained in a fall from a bicycle. During treatment for elevations of intracranial pressure, she received a continuous propofol infusion (100 \u00b5g\/kg\/min). The patient began to exhibit severe high anion gap\/low lactate metabolic acidosis, and was transferred to the pediatric intensive care unit at the authors' institution. On arrival there, the patient's Glasgow Coma Scale score was 3 and this remained unchanged during her brief stay. The severe metabolic acidosis was unresponsive to maximum therapy. Acute renal failure ensued as a result of rhabdomyolysis, and myocardial dysfunction with bizarre, wide QRS complexes developed without hyperkalemia. The patient died of myocardial collapse with severe metabolic acidosis and multisystem organ failure (involving renal, hepatic, and cardiac systems) approximately 15 hours after admission to the authors' institution.<\/jats:p>\n<jats:p content-type=\"fine-print\">This patient represents another case of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse observed after a prolonged propofol infusion in a pediatric patient. The authors suggest selection of other pharmacological agents for long-term sedation in pediatric patients.<\/jats:p>","DOI":"10.3171\/jns.2001.95.6.1053","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:33:58Z","timestamp":1242236038000},"page":"1053-1056","source":"Crossref","is-referenced-by-count":72,"title":["Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion"],"prefix":"10.3171","volume":"95","author":[{"given":"Michael L.","family":"Cannon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Glazier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren A.","family":"Bauman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Lancet","first-page":"704","article-title":"Comparison of propofol and midazolam for sedation in critically ill patients.","volume":"2","author":"Aitkenhead","year":"1989"},{"key":"b2","series-title":"Anaesthesia","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1365-2044.1995.tb04544.x","article-title":"Fatal myocardial failure associated with a propofol infusion in a child.","volume":"50","author":"Bray","year":"1995"},{"key":"b3","series-title":"Anesth Analg","first-page":"35","article-title":"Hemodynamic and cardiodynamic effects of propofol and etomidate: negative inotropic properties of propofol.","volume":"69","author":"Brussel","year":"1989"},{"key":"b4","series-title":"Acta Anaesthesiol Belg","first-page":"19","article-title":"Massive ketonuria during sedation with propofol in a 12 year old girl with severe head trauma.","volume":"45","author":"Canivet","year":"1994"},{"key":"b5","series-title":"Crit Care Med","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1097\/00003246-199812000-00046","article-title":"Lactic acidemia and bradyarrhythmia in a child sedated with propofol.","volume":"26","author":"Cray","year":"1998"},{"key":"b6","series-title":"Anaesthesia","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1111\/j.1365-2044.1995.tb05874.x","article-title":"Does propofol cause deaths in children?","volume":"50","author":"Dearlove","year":"1995"},{"key":"b7","series-title":"Drugs","first-page":"636","article-title":"Propofol. 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