{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:47:00Z","timestamp":1791082020455,"version":"4.1.0"},"reference-count":63,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The prevalence of unruptured cerebral aneurysms is unknown, but is estimated to be as high as 5%. The goal of this study was to determine the prevalence of asymptomatic incidental aneurysms.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> The authors studied all cerebral arteriography reports produced at a single institution, the University of Virginia, between April 1969 and January 1980. A review of 3684 arteriograms demonstrated 24 cases of asymptomatic aneurysms, yielding a prevalence rate of 0.65%. The majority (67%) of the 24 patients harboring unruptured aneurysms were women. More than 90% of the unruptured aneurysms were located in the anterior circulation and in locations similar to those found in patients with ruptured aneurysms. Nearly 80% of the aneurysms were smaller than 1 cm in their greatest diameter. The frequency of asymmetrical unruptured aneurysms (0.6\u20131.5%) was constant throughout all relevant age ranges (35\u201384 years).<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> While keeping in mind appropriate caveats in extrapolating from these data, the prevalence rate of asymptomatic unruptured aneurysms found in the present study allows an estimation of the yearly rate of rupture of these lesions. The authors suggest that this yearly rate of rupture falls within the range of 1 to 2%.<\/jats:p>","DOI":"10.3171\/jns.2002.96.1.0043","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:51:36Z","timestamp":1242237096000},"page":"43-49","source":"Crossref","is-referenced-by-count":163,"title":["Prevalence of asymptomatic incidental aneurysms: review of 4568 arteriograms"],"prefix":"10.3171","volume":"96","author":[{"given":"H. Richard","family":"Winn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Jane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin W.","family":"Britz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Surg Neurol","first-page":"227","article-title":"The New England Journal of Medicine report on unruptured intracranial aneurysms: a critique.","volume":"51","author":"Ausman","year":"1999"},{"key":"b2","series-title":"Surg Neurol","first-page":"429","article-title":"A response from the ISUIA.","volume":"52","author":"Ausman","year":"1999"},{"key":"b3","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.1161\/01.STR.31.11.2742","article-title":"Recommendations for the management of patients with unruptured intracranial aneurysms. A statement for healthcare professionals from the Stroke Council of the American Heart Association.","volume":"31","author":"Bederson","year":"2000"},{"key":"b4","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1056\/NEJM199905063401815","article-title":"Unruptured intracranial aneurysms.","volume":"340","author":"Berenstein","year":"1999"},{"key":"b5","series-title":"Forensic Sci Int","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0379-0738(84)90027-6","article-title":"Ruptured berry aneurysm: a clinical, pathological and forensic review.","volume":"26","author":"Bowen","year":"1984"},{"key":"b6","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1097\/00006123-200012000-00019","article-title":"Unruptured intracranial aneurysms: appraisal of the literature and suggested recommendations for surgery, using evidence-based medicine criteria.","volume":"47","author":"Brennan","year":"2000"},{"key":"b7","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/1531-8249(200007)48:1<5::AID-ANA1>3.0.CO;2-X","article-title":"Coiling, clipping, or medical management of unruptured intracranial aneurysms: time to randomize?","volume":"48","author":"Broderick","year":"2000"},{"key":"b8","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1212\/WNL.8.1.41","article-title":"Berry aneurysms of the circle of Willis. Results of a planned autopsy study.","volume":"8","author":"Chason","year":"1958"},{"key":"b9","series-title":"Arch Pathol","first-page":"296","article-title":"Cerebrovascular accidents. A study of two hundred one cases.","volume":"60","author":"Cohen","year":"1955"},{"key":"b10","series-title":"Brain","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/brain\/90.4.759","article-title":"Intracerebral microaneurysms and small cerebrovascular lesions.","volume":"90","author":"Cole","year":"1967"},{"key":"b11","series-title":"N Engl J Med","first-page":"1440","article-title":"Unruptured intracranial aneurysms.","volume":"340","author":"Connolly","year":"1999"},{"key":"b12","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1136\/bmj.1.5496.1138","article-title":"Mechanism of growth and rupture in cerebral berry aneurysms.","volume":"1","author":"Crompton","year":"1966"},{"key":"b13","series-title":"Am J Med","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/0002-9343(85)90218-9","article-title":"Risk factors for the development and rupture of intracranial berry aneurysms.","volume":"78","author":"de la Monte","year":"1985"},{"key":"b14","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1227\/00006123-199501000-00037","article-title":"Early experience with spiral CT in the diagnosis of intracranial aneurysms.","volume":"36","author":"Dorsch","year":"1995"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3171\/jns.2002.96.1.0052","article-title":"Unruptured aneurysms.","volume":"96","author":"Dumont","year":"2002"},{"key":"b16","series-title":"Intracranial Aneurysms.","first-page":"15","author":"Fox","year":"1983"},{"key":"b17","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/S0140-6736(00)02689-1","article-title":"Traumatic brain injury.","volume":"356","author":"Ghajar","year":"2000"},{"key":"b18","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3171\/jns.1981.55.4.0524","article-title":"Risk of bleeding from unruptured aneurysm in cases with multiple intracranial aneurysms.","volume":"55","author":"Heiskanen","year":"1981"},{"key":"b19","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/00005072-195807000-00001","article-title":"A systematic analysis of intracranial aneurysms from the autopsy file of the Presbyterian Hospital, 1914\u20131956.","volume":"17","author":"Houspian","year":"1958"},{"key":"b20","series-title":"AJNR","first-page":"1607","article-title":"Blinded prospective evaluation of sensitivity of MR angiography to known intracranial aneurysms: importance of aneurysm size.","volume":"15","author":"Huston","year":"1994"},{"key":"b21","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0090-3019(90)90237-J","article-title":"Autopsy study of unruptured incidental intracranial aneurysms.","volume":"34","author":"Inagawa","year":"1990"},{"key":"b22","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0090-3019(90)90020-P","article-title":"Ruptured intracranial aneurysms: an autopsy study of 133 patients.","volume":"33","author":"Inagawa","year":"1990"},{"key":"b23","series-title":"N Engl J Med","first-page":"1725","article-title":"Unruptured intracranial aneurysms\u2014risk of rupture and risks of surgical intervention.","volume":"339","year":"1998"},{"key":"b24","series-title":"Acad Emerg Med","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1553-2712.2000.tb00515.x","article-title":"Traumatic brain injuries evaluated in U.S. emergency departments, 1992\u20131994.","volume":"7","author":"Jager","year":"2000"},{"key":"b25","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3171\/jns.1985.62.3.0321","article-title":"The natural history of aneurysms and arteriovenous malformations.","volume":"62","author":"Jane","year":"1985"},{"key":"b26","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3171\/jns.2002.96.1.0058","article-title":"Unruptured aneurysms.","volume":"96","author":"Juvela","year":"2002"},{"key":"b27","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3171\/jns.1993.79.2.0174","article-title":"Natural history of unruptured intracranial aneurysms: a long-term follow-up study.","volume":"79","author":"Juvela","year":"1993"},{"key":"b28","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3171\/jns.2000.93.3.0379","article-title":"Natural history of unruptured intracranial aneurysms: probability of and risk factors for aneurysm rupture.","volume":"93","author":"Juvela","year":"2000"},{"key":"b29","series-title":"Int Anesthesiol Clin","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00004311-198220020-00005","article-title":"Epidemiology of intracranial aneurysms.","volume":"20","author":"Kassell","year":"1982"},{"key":"b30","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1161\/01.STR.15.3.566","article-title":"The International Cooperative Study on Timing of Aneurysm Surgery\u2014an update.","volume":"15","author":"Kassell","year":"1984"},{"key":"b31","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1227\/00006123-198303000-00007","article-title":"Size of intracranial aneurysms.","volume":"12","author":"Kassell","year":"1983"},{"key":"b32","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3171\/jns.1966.25.3.0321","article-title":"Natural history of subarachnoid hemorrhage, intracranial aneurysms and arteriovenous malformations.","volume":"25","author":"Locksley","year":"1966"},{"key":"b33","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3171\/jns.1970.33.4.0422","article-title":"The size of intracranial saccular aneurysms. An autopsy study.","volume":"33","author":"McCormick","year":"1970"},{"key":"b34","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3171\/jns.1965.22.2.0155","article-title":"Saccular intracranial aneurysms. An autopsy study.","volume":"22","author":"McCormick","year":"1965"},{"key":"b35","series-title":"Cerebral Aneurysm. Experiences with 1000 Directly Operated Cases.","first-page":"163","article-title":"Angiographic study of intracranial saccular aneurysms: with particular reference to their size and shape","author":"Mizoi","year":"1979"},{"key":"b36","series-title":"Neurol Scand","first-page":"1","article-title":"Incidence, aetiology, and prognosis of primary subarachnoid hemorrhage. A study based on 589 cases diagnosed in a defined urban population during a defined period.","volume":"43","author":"Pakarinen","year":"1967"},{"key":"b37","series-title":"Br J Radiol","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1259\/0007-1285-32-374-85","article-title":"III. The accuracy of radiology in demonstrating ruptured intracranial aneurysms.","volume":"32","author":"Perret","year":"1959"},{"key":"b38","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1212\/WNL.30.10.1034","article-title":"The unchanging pattern of subarachnoid hemorrhage in a community.","volume":"30","author":"Phillips","year":"1980"},{"key":"b39","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3171\/jns.2002.96.1.0063","article-title":"Unruptured aneurysms.","volume":"96","author":"Piepgras","year":"2002"},{"key":"b40","series-title":"Surg Neurol","first-page":"428","article-title":"A response from the ISUIA.","volume":"52","author":"Piepgras","year":"1999"},{"key":"b41","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1136\/bmj.1.1528.827","article-title":"The Goulstonian Lectures on some cerebral lesions.","volume":"1","author":"Pitt","year":"1890"},{"key":"b42","series-title":"Medicine","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-194102000-00001","article-title":"Intracranial aneurysms. A clinical and pathological study of subarachnoid and intracerebral hemorrhage caused by berry aneurysms.","volume":"20","author":"Richardson","year":"1941"},{"key":"b43","series-title":"Arch Neurol Psychiatry","first-page":"615","article-title":"Miliary aneurysms: relation of anomalies of the circle of Willis to formation of aneurysms.","volume":"49","author":"Riggs","year":"1943"},{"key":"b44","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3171\/jns.2002.96.1.0061","article-title":"Unruptured aneurysms.","volume":"96","author":"Riina","year":"2002"},{"key":"b45","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1161\/01.STR.29.1.251","article-title":"Prevalence and risk of rupture of intracranial aneurysms: a systematic review.","volume":"29","author":"Rinkel","year":"1998"},{"key":"b46","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF01809260","article-title":"Does a safe size-limit exist for unruptured intracranial aneurysms?","volume":"121","author":"Rosenorn","year":"1993"},{"key":"b47","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3109\/02688698809001008","article-title":"Unruptured intracranial aneurysms: an assessment of the annual risk of rupture based on epidemiological and clinical data.","volume":"2","author":"Rosenorn","year":"1988"},{"key":"b48","series-title":"Brain","first-page":"489","article-title":"Intracranial aneurysms.","volume":"53","author":"Schmidt","year":"1930"},{"key":"b49","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1227\/00006123-198102000-00020","article-title":"Origin, growth, and rutpure of saccular aneurysms: a review.","volume":"8","author":"Sekhar","year":"1981"},{"key":"b50","series-title":"Arch Pathol","first-page":"45","article-title":"Aneurysms and anatomical variation of cerebral arteries.","volume":"75","author":"Stehbens","year":"1963"},{"key":"b51","series-title":"Pathology of the Cerebral Blood Vessels.","first-page":"351","author":"Stehbens","year":"1972"},{"key":"b52","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3171\/jns.2000.93.4.0550","article-title":"Risk of rupture from incidental cerebral aneurysms.","volume":"93","author":"Tsutsumi","year":"2000"},{"key":"b53","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1161\/01.STR.30.6.1181","article-title":"Risk of subarachnoid hemorrhage after surgical treatment of unruptured cerebral aneurysms.","volume":"30","author":"Tsutsumi","year":"1999"},{"key":"b54","series-title":"Brain","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1093\/brain\/41.1.50","article-title":"Intracranial aneurysms.","volume":"41","author":"Turnbull","year":"1918"},{"key":"b55","series-title":"Current Population Reports. National and State Population Estimates: 1990 to 1994.","first-page":"25","year":"1994"},{"key":"b56","series-title":"Eur Radiol","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s003300050531","article-title":"Comparative evaluation of cerebral aneurysms with selective arterially enhanced CT and DSA.","volume":"8","author":"Vanderschelden","year":"1998"},{"key":"b57","series-title":"Brain","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/brain\/123.2.205","article-title":"The detection and management of unruptured intracranial aneurysms.","volume":"123","author":"Wardlaw","year":"2000"},{"key":"b58","series-title":"Aneurysms Affecting the Nervous System.","first-page":"226","author":"Weir","year":"1987"},{"key":"b59","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3171\/jns.2002.96.1.0050","article-title":"Unruptured aneurysms.","volume":"96","author":"Wiebers","year":"2002"},{"key":"b60","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3171\/jns.1987.66.1.0023","article-title":"The significance of unruptured intracranial saccular aneuryms.","volume":"66","author":"Wiebers","year":"1987"},{"key":"b61","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3171\/jns.1983.59.4.0642","article-title":"The long-term outcome in patients with multiple aneurysms. Incidence of late hemorrhage and implications for treatment of incidental aneurysms.","volume":"59","author":"Winn","year":"1983"},{"key":"b62","series-title":"Stroke","first-page":"121","article-title":"Prevalence of asymptomatic incidental aneurysms: review of 4,568 arteriograms.","volume":"14","author":"Winn","year":"1983"},{"key":"b63","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1097\/00006123-199706000-00007","article-title":"Long-term follow-up study of unruptured intracranial aneurysms.","volume":"40","author":"Yasui","year":"1997"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/1\/article-p43.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/1\/article-p43.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/1\/article-p43.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T21:53:22Z","timestamp":1679867602000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/1\/article-p43.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":63,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.2002.96.1.0043","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}