{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:43:16Z","timestamp":1773308596895,"version":"3.50.1"},"reference-count":23,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The benefits of measuring cerebral oxygenation in patients with brain injury are well accepted; however, jugular bulb oximetry, which is currently the most popular monitoring technique used has several shortcomings. The goal of this study was to validate the use of a new multiparameter sensor that measures brain tissue oxygenation and metabolism (Neurotrend) by comparing it with positron emission tomography (PET) scanning.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> A Neurotrend sensor was inserted into the frontal region of the brain in 19 patients admitted to the neurointensive care unit. After a period of stabilization, the patients were transferred to the PET scanner suite where C<jats:sup>15<\/jats:sup>O, <jats:sup>15<\/jats:sup>O<jats:sub>2<\/jats:sub>, and H<jats:sub>2<\/jats:sub><jats:sup>15<\/jats:sup>O PET scans were obtained to facilitate calculation of regional cerebral blood volume, O<jats:sub>2<\/jats:sub> metabolism, blood flow, and O<jats:sub>2<\/jats:sub> extraction fraction (OEF). Patients were given hyperventilation therapy to decrease arterial CO<jats:sub>2<\/jats:sub> by approximately 1 kPa (7.5 mm Hg) and the same sequence of PET scans was repeated. For each scanning sequence, end-capillary O<jats:sub>2<\/jats:sub> tension (PvO<jats:sub>2<\/jats:sub>) was calculated from the OEF and compared with the reading of brain tissue O<jats:sub>2<\/jats:sub> pressure (PbO<jats:sub>2<\/jats:sub>) provided by the sensor.<\/jats:p>\n<jats:p content-type=\"fine-print\">In three patients the sensor was inserted into areas of contusion and these patients were eliminated from the analysis. In the subset of 16 patients in whom the sensor was placed in healthy brain, no correlation was found between the absolute values of PbO<jats:sub>2<\/jats:sub> and PvO<jats:sub>2<\/jats:sub> (r = 0.2, p = 0.29); however a significant correlation was obtained between the change in PbO<jats:sub>2<\/jats:sub> (\u0394PbO<jats:sub>2<\/jats:sub>) and the change in PvO<jats:sub>2<\/jats:sub> (\u0394PvO<jats:sub>2<\/jats:sub>) produced by hyperventilation in a 20-mm region of interest around the sensor (\u03c1 = 0.78, p = 0.0035).<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> The lack of correlation between the absolute values of PbO<jats:sub>2<\/jats:sub> and PvO<jats:sub>2<\/jats:sub> indicates that PbO<jats:sub>2<\/jats:sub> cannot be used as a substitute for PvO<jats:sub>2<\/jats:sub>. Nevertheless, the positive correlation between \u0394PbO<jats:sub>2<\/jats:sub> and \u0394PvO<jats:sub>2<\/jats:sub> when the sensor had been inserted into healthy brain suggests that tissue PO<jats:sub>2<\/jats:sub> monitoring may provide a useful tool to assess the effect of therapeutic interventions in brain injury.<\/jats:p>","DOI":"10.3171\/jns.2002.96.2.0263","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:47:54Z","timestamp":1242236874000},"page":"263-268","source":"Crossref","is-referenced-by-count":88,"title":["Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method"],"prefix":"10.3171","volume":"96","author":[{"given":"Arun K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pippa G.","family":"Al-Rawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dot A.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan S.","family":"Minhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupert","family":"Kett-White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Kirkpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian C.","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Downey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin","family":"Aigbirhio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Pickard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Cereb Blood Flow Metab","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/jcbfm.1988.76","article-title":"Measurement of end-capillary PO2 with positron emission tomography.","volume":"8","author":"Alpert","year":"1988"},{"key":"b2","series-title":"Acta Neurochir Suppl","first-page":"121","article-title":"Early and late systemic hypotension as a frequent and fundamental source of cerebral ischemia following severe brain injury in the Traumatic Coma Data Bank.","volume":"59","author":"Chesnut","year":"1993"},{"key":"b3","series-title":"Trans Am Soc Artif Int Org","first-page":"41","article-title":"Monitor and control of blood and tissue oxygen tensions.","volume":"2","author":"Clark","year":"1956"},{"key":"b4","series-title":"Crit Care Clin","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0749-0704(05)70296-7","article-title":"Monitoring of cerebral hemodynamics with jugular bulb catheters.","volume":"13","author":"Feldman","year":"1997"},{"key":"b5","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1097\/00004728-198012000-00001","article-title":"Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure and normal values.","volume":"4","author":"Frackowiak","year":"1980"},{"key":"b6","series-title":"Anesth Analg","first-page":"549","article-title":"Measurement of brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury.","volume":"88","author":"Gupta","year":"1999"},{"key":"b7","series-title":"Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management.","first-page":"761","article-title":"Application of positron emission tomography to the study of cerebral ischemia","volume":"2","author":"Heiss","year":"1998"},{"key":"b8","series-title":"Anesth Analg","first-page":"582","article-title":"Brain tissue oxygen, carbon dioxide, and pH in neurosurgical patients at risk for ischemia.","volume":"82","author":"Hoffman","year":"1996"},{"key":"b9","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/01616412.1999.11740943","article-title":"Monitoring of brain metabolism during aneurysm surgery using microdialysis and brain multiparameter sensors.","volume":"21","author":"Hutchinson","year":"1999"},{"key":"b10","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1152\/jappl.1966.21.4.1375","article-title":"Digital computer subroutine for the conversion of oxygen tension into saturation.","volume":"21","author":"Kelman","year":"1966"},{"key":"b11","series-title":"Brain","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/brain\/113.1.27","article-title":"Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age.","volume":"113","author":"Leenders","year":"1990"},{"key":"b12","series-title":"Crit Care Med","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1097\/00003246-199611000-00016","article-title":"Brain parenchyma PO2, PCO2, and pH during and after hypoxic, ischemic brain insult in dogs.","volume":"24","author":"McKinley","year":"1996"},{"key":"b13","series-title":"Acta Neurochir Suppl","first-page":"58","article-title":"Studies of tissue pO2 in normal and pathological human brain cortex.","volume":"59","author":"Meixensberger","year":"1993"},{"key":"b14","series-title":"Br Med Bull","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1258\/0007142991902231","article-title":"Cerebral protection in severe brain injury: physiological determinants of outcome and their optimisation.","volume":"55","author":"Menon","year":"1999"},{"key":"b15","series-title":"J Neurosurg Anesthesiol","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1097\/00008506-199910000-00003","article-title":"Cerebral oxygenation in patients after severe head injury: monitoring and effects of arterial hyperoxia on cerebral blood flow, metabolism and intracranial pressure.","volume":"11","author":"Menzel","year":"1999"},{"key":"b16","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/jns.1999.91.1.0001","article-title":"Increased inspired oxygen concentration as a factor of improved brain tissue oxygenation and tissue lactate levels after severe human head injury.","volume":"91","author":"Menzel","year":"1999"},{"key":"b17","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/bja\/57.1.120","article-title":"Head injury and brain ischaemia\u2014implications for therapy.","volume":"57","author":"Miller","year":"1985"},{"key":"b18","series-title":"J Neurosurg","first-page":"363","article-title":"Near-infrared spectroscopy.","volume":"85","author":"Misra","year":"1996"},{"key":"b19","series-title":"Arch Dis Childhood Fetal Neonatal Ed","doi-asserted-by":"publisher","first-page":"F93","DOI":"10.1136\/fn.80.2.F93","article-title":"Continuous neonatal blood gas monitoring using a multiparameter intra-arterial sensor.","volume":"80","author":"Morgan","year":"1999"},{"key":"b20","series-title":"J Neurotrauma","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1089\/neu.1998.15.813","article-title":"Brain parenchyma\/pO2 catheter interface: a histopathological study in the rat.","volume":"15","author":"van den Brink","year":"1998"},{"key":"b21","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00006123-199601000-00007","article-title":"Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury.","volume":"38","author":"van Santbrink","year":"1996"},{"key":"b22","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1227\/00006123-199512000-00017","article-title":"Brain oxygen, CO2, pH, and temperature monitoring: evaluation in the feline brain.","volume":"37","author":"Zauner","year":"1995"},{"key":"b23","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/01616412.1997.11740812","article-title":"Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients.","volume":"19","author":"Zauner","year":"1997"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/2\/article-p263.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/2\/article-p263.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/2\/article-p263.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T21:48:21Z","timestamp":1679867301000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/2\/article-p263.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":23,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.2002.96.2.0263","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}