{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:22:05Z","timestamp":1790032925814,"version":"4.0.1"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> Hearing loss is the most common presenting symptom in patients who harbor a vestibular schwannoma (VS). Although mechanical injury to the cochlear nerve and vascular compromise of the auditory apparatus have been proposed, the exact mechanism of this hearing loss remains unclear. To test whether pressure on the cochlear nerve from tumor growth in the internal auditory canal (IAC) is responsible for this clinical finding, the authors prospectively evaluated intracanalicular pressure (ICaP) in patients with VS and correlated this with preoperative brainstem response.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> In 40 consecutive patients undergoing a retrosigmoid\u2014transmeatal approach for tumor excision, ICaP was measured by inserting a pressure microsensor into the IAC before any tumor manipulation. Pressure recordings were correlated with tumor size and preoperative auditory evoked potential (AEP) recordings.<\/jats:p>\n<jats:p content-type=\"fine-print\">The ICaP, which varied widely among patients (range 0\u201345 mm Hg), was significantly elevated in most patients (median 16 mm Hg). Although these pressure measurements directly correlated to the extension of tumor into the IAC (p = 0.001), they did not correlate to total tumor size (p = 0.2). In 20 patients in whom baseline AEP recordings were available, the ICaP directly correlated to wave V latency (p = 0.0001), suggesting that pressure from tumor growth in the IAC may be responsible for hearing loss in these patients.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> Tumor growth into the IAC results in elevation of ICaP and may play a role in hearing loss in patients with VS. The relevance of these findings to the surgical treatment of these tumors is discussed.<\/jats:p>","DOI":"10.3171\/jns.2002.96.5.0872","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:44:41Z","timestamp":1242236681000},"page":"872-876","source":"Crossref","is-referenced-by-count":40,"title":["Correlation between auditory function and internal auditory canal pressure in patients with vestibular schwannomas"],"prefix":"10.3171","volume":"96","author":[{"given":"Samir B.","family":"Lapsiwala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Mark","family":"Pyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann W.","family":"Kaemmerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Sasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam","family":"Badie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Otolaryngol Head Neck Surg","first-page":"179","article-title":"Committee on Hearing and Equilibrium guidelines for the evaluation of hearing preservation in acoustic neuroma (vestibular schwannoma). American Academy of Otolaryngology-Head and Neck Surgery Foundation, INC.","volume":"113","year":"1995"},{"key":"b2","series-title":"Am J Otol","first-page":"465","article-title":"Clinical correlates of acoustic neuroma volume.","volume":"14","author":"Arriaga","year":"1993"},{"key":"b3","series-title":"Otol Neurotol","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1097\/00129492-200109000-00024","article-title":"Elevation of internal auditory canal pressure by vestibular schwannomas.","volume":"22","author":"Badie","year":"2001"},{"key":"b4","series-title":"Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/019459988609400103","article-title":"Acoustic neuroma presenting as sudden hearing loss with recovery.","volume":"94","author":"Berg","year":"1986"},{"key":"b5","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/S0022-510X(96)00174-8","article-title":"Acoustic neuroma: correlations between morphology and otoneurological manifestations.","volume":"144","author":"Berrettini","year":"1996"},{"key":"b6","series-title":"Am J Otolaryngol","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0196-0709(99)90063-7","article-title":"Sudden hearing loss as a presenting symptom of acoustic neuroma.","volume":"20","author":"Chaimoff","year":"1999"},{"key":"b7","series-title":"Am J Otolaryngol","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0196-0709(85)80049-1","article-title":"Acoustic neuroma presenting as sudden hearing loss.","volume":"6","author":"Chow","year":"1985"},{"key":"b8","series-title":"Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0194-5998(99)70382-7","article-title":"Retrosigmoid-transmeatal en bloc removal of small to medium-sized acoustic neuromas.","volume":"120","author":"Colletti","year":"1999"},{"key":"b9","series-title":"Arch Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1001\/archotol.124.6.678","article-title":"Chronic conductive hearing loss in adults: effects on the auditory brainstem response and masking-level difference.","volume":"124","author":"Ferguson","year":"1998"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3171\/jns.1993.79.4.0515","article-title":"Intracanalicular acoustic neuroma: early surgery for preservation of hearing.","volume":"79","author":"Haines","year":"1993"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3171\/jns.1998.88.5.0840","article-title":"Hearing preservation in patients undergoing vestibular schwannoma surgery: comparison of middle fossa and retrosigmoid approaches.","volume":"88","author":"Irving","year":"1998"},{"key":"b12","series-title":"Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1177\/019459988910000613","article-title":"Cochlear nerve conduction block: an explanation for spontaneous hearing return after acoustic tumor surgery.","volume":"100","author":"Kveton","year":"1989"},{"key":"b13","series-title":"Br J Audiol","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3109\/03005369309076695","article-title":"Correcting for factors affecting ABR wave V latency.","volume":"27","author":"Lightfoot","year":"1993"},{"key":"b14","series-title":"Neurosurgery","first-page":"1","article-title":"Management of 1000 vestibular schwannomas (acoustic neuromas): clinical presentation.","volume":"40","author":"Matthies","year":"1997"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"938","DOI":"10.3171\/jns.1984.61.5.0938","article-title":"Use of intraoperative auditory evoked potentials to preserve hearing in unilateral acoustic neuroma removal.","volume":"61","author":"Ojemann","year":"1984"},{"key":"b16","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/00006123-199702000-00005","article-title":"Management of 1000 vestibular schwannomas (acoustic neuromas): hearing function in 1000 tumor resections.","volume":"40","author":"Samii","year":"1997"},{"key":"b17","series-title":"Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0194-5998(95)70140-0","article-title":"Sudden hearing loss in acoustic neuroma patients.","volume":"113","author":"Saunders","year":"1995"},{"key":"b18","series-title":"Anesth Analg","first-page":"817","article-title":"The effects of anesthesia with increasing end-expiratory concentrations of sevoflurane on midlatency auditory evoked potentials.","volume":"81","author":"Schwender","year":"1995"},{"key":"b19","series-title":"Anaesthesia","first-page":"572","article-title":"Effects of surgical stimulation on midlatency auditory evoked potentials during general anaesthesia with propofol\/fentanyl, isoflurane\/fentanyl and flunitrazepam\/fentanyl.","volume":"49","author":"Schwender","year":"1994"},{"key":"b20","series-title":"Laryngoscope","first-page":"925","article-title":"The treatment of small acoustic tumors: now or later?","volume":"101","author":"Shelton","year":"1991"},{"key":"b21","series-title":"Acta Neurochir Suppl","first-page":"27","article-title":"Intraoperative monitoring of the electrocochleogram and the preservation of hearing during acoustic neuroma excision.","volume":"42","author":"Symon","year":"1988"},{"key":"b22","series-title":"Laryngoscope","first-page":"308","article-title":"Sudden hearing loss induced by acoustic neuroma: significance of small tumors.","volume":"103","author":"Yanagihara","year":"1993"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/5\/article-p872.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/5\/article-p872.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/5\/article-p872.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T21:45:26Z","timestamp":1679867126000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/5\/article-p872.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":22,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.2002.96.5.0872","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}