{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:22:14Z","timestamp":1791973334565,"version":"4.3.4"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> Recently developed novel MR protocols called MR neurography, which feature conspicuity for nerve, have been shown to demonstrate signal change and altered median nerve configuration in patients with median nerve compression. The postoperative course following median nerve decompression can be problematic, with persistent symptoms and abnormal results on electrophysiological studies for some months, despite successful surgical decompression. The authors undertook a prospective study in patients with carpal tunnel syndrome, correlating the clinical, electrophysiological, and MR neurography findings before and 3 months after surgery.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Thirty patients and eight control volunteers were recruited to the study. The MR neurography consisted of axial and sagittal images (TR = 2000 msec, TE = 60 msec) obtained using a temporomandibular surface coil, fat saturation, and flow suppression. Maximum intensity projection images were used to follow the median nerve through the carpal tunnel in the sagittal plane.<\/jats:p>\n<jats:p content-type=\"fine-print\">Magnetic resonance neurography in patients with carpal tunnel syndrome demonstrated proximal swelling (p &lt; 0.001) and high signal change in the nerve, together with increased flattening ratios (p &lt; 0.001) and loss of nerve signal in the distal carpal tunnel (p &lt; 0.05). Sagittal images were very effective in precisely demonstrating the site and severity of nerve compression. After surgery, division of the flexor retinaculum could be demonstrated in all cases. Changes in nerve configuration, including increased cross-sectional area, and reduced flattening ratios (p &lt; 0.001) were seen in all patients. In many cases restoration of the T<jats:sub>2<\/jats:sub> signal intensity toward that of controls was seen in the median nerve in the distal carpal tunnel. Sagittal images were excellent in demonstrating expansion of the nerve at the site of surgical decompression.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> In this study the authors suggest that MR neurography is an effective means of both confirming compression of the median nerve and its successful surgical decompression in patients with carpal tunnel syndrome. This modality may prove useful in the assessment of unconfirmed or complex cases of carpal tunnel syndrome both before and after surgery.<\/jats:p>","DOI":"10.3171\/jns.2002.96.6.1046","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:44:46Z","timestamp":1242236686000},"page":"1046-1051","source":"Crossref","is-referenced-by-count":96,"title":["Magnetic resonance neurography studies of the median nerve before and after carpal tunnel decompression"],"prefix":"10.3171","volume":"96","author":[{"given":"Simon A.","family":"Cudlip","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklyn A.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Clifton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Anthony","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Magn Reson Imaging Clin N Am","first-page":"179","article-title":"MR neurography. MR imaging of peripheral nerves.","volume":"6","author":"Aagaard","year":"1998"},{"key":"b2","series-title":"Eur J Radiol","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0720-048X(96)01038-8","article-title":"MR imaging of the carpal tunnel.","volume":"25","author":"Allmann","year":"1997"},{"key":"b3","series-title":"Rheum Dis Clin North Am","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S0889-857X(21)00115-0","article-title":"Magnetic resonance imaging of the wrist.","volume":"17","author":"Brahme","year":"1991"},{"key":"b4","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1227\/00006123-199512000-00009","article-title":"Carpal tunnel syndrome: correlation of magnetic resonance imaging, clinical, electrodiagnostic, and intraoperative findings.","volume":"37","author":"Britz","year":"1995"},{"key":"b5","series-title":"Chir Organi Mov","first-page":"157","article-title":"Carpal tunnel syndrome: the role of tridimensional computerized tomography.","volume":"79","author":"Cartolari","year":"1994"},{"key":"b6","series-title":"J Hand Surg (Am)","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0363-5023(97)80120-7","article-title":"Assessment of the ratio of carpal contents to carpal tunnel volume in patients with carpal tunnel syndrome: a preliminary report.","volume":"22","author":"Cobb","year":"1997"},{"key":"b7","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/S0140-6736(97)24043-2","article-title":"Magnetic resonance neurography of peripheral nerve degeneration and regeneration.","volume":"350","author":"Dailey","year":"1997"},{"key":"b8","series-title":"Neurosurgery","first-page":"488","article-title":"Magnetic resonance neurography for cervical radiculopathy: a preliminary report.","volume":"38","author":"Dailey","year":"1996"},{"key":"b9","series-title":"Hand Clin","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0749-0712(21)01312-3","article-title":"Magnetic resonance imaging of the wrist.","volume":"7","author":"Dalinka","year":"1991"},{"key":"b10","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/0140-6736(93)90422-D","article-title":"Magnetic resonance neurography.","volume":"341","author":"Filler","year":"1993"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3171\/jns.1996.85.2.0299","article-title":"Application of magnetic resonance neurography in the evaluation of patients with peripheral nerve pathology.","volume":"85","author":"Filler","year":"1996"},{"key":"b12","series-title":"Orthop Clin North Am","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0030-5898(20)30335-7","article-title":"Carpal tunnel syndrome. A scientific basis for clinical care.","volume":"19","author":"Gelberman","year":"1988"},{"key":"b13","series-title":"J Hand Surg (Br)","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0266-7681_90_90131-M","article-title":"Magnetic resonance imaging of the carpal tunnel.","volume":"15","author":"Healy","year":"1990"},{"key":"b14","series-title":"Magn Reson Med","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/mrm.1910280215","article-title":"Magnetic resonance neurography.","volume":"28","author":"Howe","year":"1992"},{"key":"b15","series-title":"Br J Radiol","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1259\/0007-1285-67-804-1169","article-title":"Magnetic resonance neurography of the median nerve.","volume":"67","author":"Howe","year":"1994"},{"key":"b16","series-title":"J Magn Reson Imaging","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/jmri.1880080518","article-title":"Carpal tunnel syndrome: staging of median nerve compression by MR imaging.","volume":"8","author":"Kleindienst","year":"1998"},{"key":"b17","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1148\/radiology.160.2.3726128","article-title":"The wrist: a preliminary report on high-resolution MR imaging.","volume":"160","author":"Koenig","year":"1986"},{"key":"b18","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1097\/00006123-199610000-00021","article-title":"Magnetic resonance neurography of peripheral nerve lesions in the lower extremity.","volume":"39","author":"Kuntz","year":"1996"},{"key":"b19","series-title":"Toxicol Pathol","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1177\/019262339001800123","article-title":"Role of the blood-nerve barrier in experimental nerve edema.","volume":"18","author":"Mizisin","year":"1990"},{"key":"b20","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0006-8993(85)90392-0","article-title":"Mammalian endoneurial fluid: collection and protein analysis from normal and crushed nerves.","volume":"332","author":"Poduslo","year":"1985"},{"key":"b21","series-title":"J Neurol","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF00920573","article-title":"The value of magnetic resonance imaging in carpal tunnel syndrome.","volume":"242","author":"Seyfert","year":"1994"},{"key":"b22","series-title":"Ital J Orthop Traumatol","first-page":"123","article-title":"MR imaging in the diagnosis of carpal tunnel syndrome.","volume":"18","author":"Soccetti","year":"1992"},{"key":"b23","series-title":"Muscle Nerve","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/mus.880100202","article-title":"AAEE minimonograph #26: The electrodiagnosis of carpal tunnel syndrome.","volume":"10","author":"Stevens","year":"1987"},{"key":"b24","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1001\/archneur.1967.00470240073010","article-title":"Electrodiagnostic aspects of the carpal tunnel syndrome.","volume":"16","author":"Thomas","year":"1967"},{"key":"b25","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1148\/radiology.160.1.3715026","article-title":"High-field MR surface-coil imaging of the hand and wrist. Part II. Pathologic correlations and clinical relevance.","volume":"160","author":"Weiss","year":"1986"},{"key":"b26","series-title":"Rev Rhum Engl Ed","first-page":"192","article-title":"Idiopathic carpal tunnel syndrome. Clinical, electrodiagnostic, and magnetic resonance imaging correlations.","volume":"66","author":"Zagnoli","year":"1999"},{"key":"b27","series-title":"Magn Reson Q","first-page":"65","article-title":"Magnetic resonance imaging of the wrist.","volume":"8","author":"Zlatkin","year":"1992"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/6\/article-p1046.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/6\/article-p1046.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/96\/6\/article-p1046.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T21:41:07Z","timestamp":1679866867000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/96\/6\/article-p1046.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":27,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/jns.2002.96.6.1046","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}