{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:34:28Z","timestamp":1783776868079,"version":"3.55.0"},"reference-count":33,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> To obtain information essential to the decision to perform radiosurgery for arteriovenous malformations (AVMs) in children and adolescents, the authors retrospectively analyzed their experience with gamma knife surgery for AVMs in 100 patients ranging in age from 4 to 19 years.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Follow-up periods ranged from 6 to 124 months (median 71 months), and the actuarial obliteration rates demonstrated by angiography were 84.1, 89.4, and 94.7% at 3, 4, and 5 years, respectively. Factors associated with better obliteration rates in univariate analysis included the following: a patient age of 12 years or younger; a mean nidus diameter of 2 cm or less; a nidus volume of 3.8 cm<jats:sup>3<\/jats:sup> or less; a maximum diameter of the nidus less than 3 cm; and a Spetzler\u2014Martin grade of III or less. Radiation-induced neuropathy was seen in four patients, and the risk factors were considered to be a nidus in the brainstem and a maximum radiation dose greater than 40 Gy. Hemorrhage developed during the latency interval in four patients, and one patient with a cerebellar AVM died of the hemorrhage. The annual bleeding rate was 1.5%. Feeding arteries located in the posterior cranial fossa and an AVM nidus located in the cerebellum were significantly associated with the risk of hemorrhage. After angiographically verified obliteration of the nidus, 51 patients continued to be observed from 1 to 110 months (median 67 months); hemorrhage developed in one patient 38 months after nidus obliteration.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> Radiosurgery is an acceptable treatment for small AVMs in children and adolescents in whom a higher obliteration rate can be achieved with lower risks of interval hemorrhage compared with the reported results in the general population. Careful follow-up observation seems to be required, however, even after angiographically verified obliteration.<\/jats:p>","DOI":"10.3171\/jns.2002.97.4.0779","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:45:47Z","timestamp":1242236747000},"page":"779-784","source":"Crossref","is-referenced-by-count":112,"title":["Retrospective analysis of a 10-year experience of stereotactic radiosurgery for arteriovenous malformations in children and adolescents"],"prefix":"10.3171","volume":"97","author":[{"given":"Masahiro","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Tago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomio","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3171\/jns.1988.68.3.0352","article-title":"The natural history of unruptured intracranial arteriovenous malformations.","volume":"68","author":"Broun","year":"1988"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3171\/jns.2000.93.supplement_3.0096","article-title":"Factors related to complete occlusion of arteriovenous malformations after gamma knife radiosurgery.","volume":"93","author":"Chang","year":"2000"},{"key":"b3","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jnnp.49.1.1","article-title":"Arteriovenous malformations of the brain: natural history in unoperated patients.","volume":"49","author":"Crawford","year":"1986"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3171\/jns.1998.89.1.0104","article-title":"Analysis of treatment failure after radiosurgery for arteriovenous malformations.","volume":"89","author":"Ellis","year":"1998"},{"key":"b5","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1227\/00006123-198411000-00003","article-title":"Natural history of arteriovenous malformations of the brain: a clinical study.","volume":"15","author":"Fults","year":"1984"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3171\/jns.1996.84.5.0879","article-title":"Recurrence of a cerebral arteriovenous malformation after surgical excision. 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