{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:45:41Z","timestamp":1768409141492,"version":"3.49.0"},"reference-count":43,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 A highly malignant brain neoplasm with rhabdoid morphological features emerged in the bed of a subtotally resected ganglioglioma in a 54-year-old retired nuclear submarine officer. A combined application of neuroimaging, immunohistochemical studies, electron microscopy, and fluorescence in situ hybridization (FISH) was used to establish the morphological identity of the tumor. The rhabdoid appearance of the tumor cells indicated either an especially malignant variant of rhabdoid meningioma or an atypical teratoid\/rhabdoid tumor with an unusually late onset. Whereas immunohistochemical studies and electron microscopy could only be used to narrow down the differential diagnosis, FISH revealed loss of one copy of <jats:italic>NF2<\/jats:italic> with preservation of the <jats:italic>INI1<\/jats:italic> region on 22q, thus establishing the identity of the tumor.<\/jats:p>","DOI":"10.3171\/jns.2002.97.6.1450","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:43:09Z","timestamp":1242236589000},"page":"1450-1455","source":"Crossref","is-referenced-by-count":30,"title":["Malignant rhabdoid meningioma arising in the setting of preexisting ganglioglioma: a diagnosis supported by fluorescence in situ hybridization"],"prefix":"10.3171","volume":"97","author":[{"given":"Sergei I.","family":"Bannykh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence A.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neuropathol Appl Neurobiol","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1046\/j.0305-1846.2001.00302.x","article-title":"Mutational analysis of TSC1 and TSC2 genes in gangliogliomas.","volume":"27","author":"Becker","year":"2001"},{"key":"b2","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1002\/1097-0142(197805)41:5<1937::AID-CNCR2820410538>3.0.CO;2-U","article-title":"Histopathology and prognosis of Wilms tumors: results from the First National Wilms' Tumor Study.","volume":"41","author":"Beckwith","year":"1978"},{"key":"b3","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1007\/s004010050470","article-title":"Immunohistochemistry of primary central nervous system malignant rhabdoid tumors: report of five cases and review of the literature.","volume":"91","author":"Behring","year":"1996"},{"key":"b4","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/BF01411306","article-title":"Primary malignant rhabdoid tumors of the central nervous system: an immunohistochemical and ultrastructural study.","volume":"139","author":"Bergmann","year":"1997"},{"key":"b5","series-title":"Ultrastruct Pathol","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3109\/01913129709021934","article-title":"Primary malignant rhabdoid tumor of the central nervous system.","volume":"21","author":"Bhattacharjee","year":"1997"},{"key":"b6","series-title":"Ultrastruct Pathol","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3109\/01913129709021935","article-title":"Central nervous system atypical teratoid\/rhabdoid tumors of infancy and childhood.","volume":"21","author":"Bhattacharjee","year":"1997"},{"key":"b7","series-title":"Cancer Res","first-page":"74","article-title":"Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors.","volume":"59","author":"Biegel","year":"1999"},{"key":"b8","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1002\/1097-0142(19841115)54:10<2137::AID-CNCR2820541014>3.0.CO;2-D","article-title":"The association of embryonal tumors originating in the kidney and in the brain. 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