{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:19:21Z","timestamp":1761823161000},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors report on a 75-year-old man with histologically benign fibroblastic meningioma metastasizing to the lung, liver, spleen, and kidney. The original tumor exhibited a complex karyotype involving different structural and numerical anomalies associated with monosomy of chromosome 22. The implication of chromosome 1p36 was confirmed by fluorescence in situ hybridization in most interphase nuclei. Metastases occurred 4 months after incomplete resection with prior therapeutic embolization. The recurrent tumor in turn displayed anaplastic features and an increased Ki-67 labeling index. Genetic alterations in such morphologically benign meningiomas have been implicated in the malignant development and progression of these tumors.<\/jats:p>","DOI":"10.3171\/jns.2003.98.1.0194","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:59:31Z","timestamp":1242237571000},"page":"194-198","source":"Crossref","is-referenced-by-count":17,"title":["Histologically benign metastatic meningioma: morphological and cytogenetic study"],"prefix":"10.3171","volume":"98","author":[{"given":"Miguel","family":"Cerd\u00e1-Nicol\u00e1s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concha","family":"Lopez-Gines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Perez-Bacete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Roldan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Talamantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Barber\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Mayo Clin Proc","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.4065\/74.11.1129","article-title":"Meningioma metastatic to the lung.","volume":"74","author":"Adlakha","year":"1999"},{"key":"b2","series-title":"Meningiomas.","year":"1991"},{"key":"b3","series-title":"Cancer Genet Cytogenet","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0165-4608(93)90239-I","article-title":"Chromosome 22 heterozygosity is retained in most hyperdiploid and pseudodiploid meningiomas.","volume":"66","author":"Bello","year":"1993"},{"key":"b4","series-title":"Russell & Rubinstein's Pathology of Tumors of the Nervous System.","year":"1998"},{"key":"b5","series-title":"Cancer of the Nervous System.","author":"Black","year":"1997"},{"key":"b6","series-title":"Tumors of the Central Nervous System.","author":"Burger","year":"1994"},{"key":"b7","series-title":"Cancer Genet Cytogenet","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0165-4608(89)90143-X","article-title":"Karyotypic evolution of human meningioma. 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