{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:52:52Z","timestamp":1762113172269},"reference-count":21,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3]]},"abstract":"Object.<\/jats:italic> The Ca++<\/jats:sup> influx into vascular smooth-muscle cells (VSMCs) plays a fundamental role in the development and chronic effects of vasospasm after subarachnoid hemorrhage (SAH). The Ca++<\/jats:sup>-permeable nonselective cation channels (NSCCs) are activated by several endothelium-derived constricting factors such as endothelin 1 (ET-1) and thromboxane A2<\/jats:sub>. Moreover, the receptor-operated Ca++<\/jats:sup> channel blocker LOE 908 inhibits ET-1\u2014induced extracellular Ca++<\/jats:sup> influx via NSCCs in the VSMCs of the basilar artery (BA) and the NSCC-dependent part of ET-1\u2014induced vasoconstriction of BA rings. The purpose of the present study was to evaluate the in vivo role of LOE 908 on SAH-induced vasospasm.<\/jats:p>\nMethods.<\/jats:italic> Forty-two Japanese white rabbits were assigned to seven groups. Treatment groups consisted of the following: 1) control rabbits without SAH that received a cisternal injection of saline; 2) rabbits with SAH that were subjected to the intravenous administration of saline; 3 through 6) rabbits with SAH that underwent the intravenous administration of 0.01, 0.1, 1, or 10 mg\/kg LOE 908, respectively; and 7) rabbits without SAH that underwent the intravenous administration of 10 mg\/kg LOE 908. Autologous blood was injected into the cisterna magna. The caliber of the BA was measured on angiographic studies before and after the cisternal injection of autologous blood.<\/jats:p>\nThe intravenous injection of LOE 908 inhibited the magnitude of an SAH-induced vasosapsm. In addition, the concentration of LOE 908 required to relax vasospasm (1 mg\/kg) correlated with that required to block Ca++<\/jats:sup> influx into VSMCs.<\/jats:p>\nConclusions.<\/jats:italic> The Ca++<\/jats:sup> channel blocker LOE 908 may inhibit the magnitude of an SAH-induced vasospasm by blocking the influx of Ca++<\/jats:sup> through NSCCs in rabbit BAs. Blocking the NSCCs may represent a new treatment for cerebral vasospasm after SAH.<\/jats:p>","DOI":"10.3171\/jns.2003.98.3.0561","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:54:51Z","timestamp":1242237291000},"page":"561-564","source":"Crossref","is-referenced-by-count":11,"title":["Effects of the Ca++-permeable nonselective cation channel blocker LOE 908 on subarachnoid hemorrhage\u2014induced vasospasm in the basilar artery in rabbits"],"prefix":"10.3171","volume":"98","author":[{"given":"Yoshifumi","family":"Kawanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoh","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Clin Chem Lab Med","first-page":"341","article-title":"Source of endothelin-1 in subarachnoid hemorrhage.","volume":"39","author":"Bertsch","year":"2001"},{"key":"b2","series-title":"Br J Pharmacol","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1111\/j.1476-5381.1996.tb15729.x","article-title":"Inhibition of a store-operated Ca2+ entry pathway in human endothelial cells by the isoquinoline derivative LOE 908.","volume":"119","author":"Encabo","year":"1996"},{"key":"b3","series-title":"Anesth Analg","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1213\/00000539-200103000-00010","article-title":"A novel approach to measuring circulating blood volume: the use of a hemoglobin-based oxygen carrier in a rabbit model.","volume":"92","author":"Jahr","year":"2001"},{"key":"b4","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1161\/01.STR.0000014563.75483.22","article-title":"Efficacy and safety of nicardipine prolonged-release implants for preventing vasospasm in humans.","volume":"33","author":"Kasuya","year":"2002"},{"key":"b5","series-title":"J Cardiovasc Pharmacol","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/00005344-200209000-00013","article-title":"Characterization of Ca2+ channels involved in endothelin-1-induced contraction of rabbit basilar artery.","volume":"40","author":"Kawanabe","year":"2002"},{"key":"b6","series-title":"Naun-Schmiedeberg Arch Pharmacol","first-page":"301","article-title":"The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells.","volume":"349","author":"Krautwurst","year":"1994"},{"key":"b7","series-title":"Mol Pharmacol","first-page":"655","article-title":"A novel potent inhibitor of receptor-activated nonselective cation currents in HL-60 cells.","volume":"43","author":"Krautwurst","year":"1993"},{"key":"b8","series-title":"J Magn Reson Imaging","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/(SICI)1522-2586(199908)10:2<138::AID-JMRI5>3.0.CO;2-G","article-title":"Neuroprotective effects of novel broad-spectrum cation channel blocker, LOE 908 MS, on experimental focal ischemia: a multispectral study.","volume":"10","author":"Li","year":"1999"},{"key":"b9","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1161\/01.STR.20.11.1553","article-title":"Endothelin acts in feline and canine cerebral arteries from the adventitial side.","volume":"20","author":"Mima","year":"1989"},{"key":"b10","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1227\/00006123-199108000-00003","article-title":"The effect of nicardipine on vasospasm in rabbit basilar artery after subarachnoid hemorrhage.","volume":"29","author":"Pasqualin","year":"1991"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3171\/jns.1995.82.1.0055","article-title":"Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage. 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