{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:03:17Z","timestamp":1787025797442,"version":"build-2736575974"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p content-type=\"fine-print\">\n                    <jats:italic>Object.<\/jats:italic>\n                    The aim of this study was to assess the effects of median nerve injury and regeneration on neuronal activation in the somatosensory cortex by means of functional magnetic resonance (fMR) imaging and somatosensory evoked potentials (SSEPs).\n                  <\/jats:p>\n                  <jats:p content-type=\"fine-print\">\n                    <jats:italic>Methods.<\/jats:italic>\n                    Ten injured male patients (mean age 26 years) were examined 15 to 58 months after a total transection of the median nerve at the wrist that was repaired with epineural sutures. Two-point discrimination was lost in Digit II\u2013III and sensory nerve conduction displayed decreased velocity (\u221229%) and amplitude (\u221284%) in the median nerve at the wrist. The fMR images were obtained during tactile stimulation (gentle strokes) performed separately on the volar surface of either Digit II\u2013III or Digit IV\u2013V (eight patients: two were excluded because of movement artifacts). The SSEPs were obtained using electrical stimulation proximal to the median nerve lesion.\n                  <\/jats:p>\n                  <jats:p content-type=\"fine-print\">\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    Patients with loss of sensory discrimination after median nerve damage and regeneration had larger areas of activation in fMR imaging near the contralateral central sulcus during tactile stimulation of the injured compared with the noninjured hand. The increase relative to the unaffected hand was 43% (p &lt; 0.02) for Digit II\u2013III stimulation and 46% (p &lt; 0.02) for Digit IV\u2013V stimulation. The SSEP data showed normal latency and amplitude. The enlarged area of cortical activation may be the result of reorganization, and it may indicate that larger cortical areas are involved in the discriminatory task after a derangement of the peripheral input.\n                  <\/jats:p>","DOI":"10.3171\/jns.2003.99.1.0100","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T13:53:09Z","timestamp":1242222789000},"page":"100-105","source":"Crossref","is-referenced-by-count":35,"title":["Loss of sensory discrimination after median nerve injury and activation in the primary somatosensory cortex on functional magnetic resonance imaging"],"prefix":"10.3171","volume":"99","author":[{"given":"Thomas","family":"Hansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Brismar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Brain Res","first-page":"27","article-title":"The reaction of primary sensory neurons to peripheral nerve injury with particular emphasis on transganglionic changes.","volume":"357","author":"Aldskogius","year":"1985"},{"key":"b2","series-title":"Brain","first-page":"2465","article-title":"Potentials evoked in human and monkey cerebral cortex by stimulation of the median nerve. A review of scalp and intracranial recordings.","volume":"114","author":"Allison","year":"1991"},{"key":"b3","series-title":"The Hand: Examination and Diagnosis.","year":"1978"},{"key":"b4","series-title":"Hand Clin","first-page":"527","article-title":"Advances in sensibility evaluation.","volume":"7","author":"Bell-Krotoski","year":"1991"},{"key":"b5","series-title":"Rehabilitation of the Hand and Upper Extremity","first-page":"214","article-title":"Sensibility assessment for nerve lesions-in-continuity and nerve lacerations","author":"Callahan","year":"2002"},{"key":"b6","series-title":"Neuroreport","first-page":"3925","article-title":"Alteration of the somatosensory cortical map in peripheral mononeuropathy due to carpal tunnel syndrome.","volume":"27","author":"Druschky","year":"2000"},{"key":"b7","series-title":"Nature","first-page":"69","article-title":"Central reorganization of sensory pathways following peripheral nerve regeneration in fetal monkeys.","volume":"381","author":"Florence","year":"1996"},{"key":"b8","series-title":"J Neurosci","first-page":"8083","article-title":"Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys.","volume":"15","author":"Florence","year":"1995"},{"key":"b9","series-title":"J Bone Joint Surg (Am)","first-page":"632","article-title":"Sensibility testing in peripheral-nerve compression syndromes. An experimental study in humans.","volume":"65","author":"Gelberman","year":"1983"},{"key":"b10","series-title":"Exp Neurol","first-page":"90","article-title":"Neurophysiological studies on patients with sutured median nerves: faulty sensory localization after nerve regeneration and its physiological correlates.","volume":"73","author":"Hallin","year":"1981"},{"key":"b11","series-title":"Neurosurgery","first-page":"677","article-title":"Functional magnetic resonance imaging of somatosensory stimulation.","volume":"35","author":"Hammeke","year":"1994"},{"key":"b12","series-title":"Neurosci Lett","first-page":"29","article-title":"Tactile stimulation of the hand causes bilateral cortical activation: a functional magnetic resonance study in humans.","volume":"271","author":"Hansson","year":"1999"},{"key":"b13","series-title":"Annu Rev Neurosci","first-page":"325","article-title":"The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals.","volume":"6","author":"Kaas","year":"1983"},{"key":"b14","series-title":"J Neurosci","first-page":"3609","article-title":"Reorganization of motor and somatosensory cortex in upper extremity amputees with phantom limb pain.","volume":"21","author":"Karl","year":"2001"},{"key":"b15","series-title":"Clin Neurophysiol","first-page":"S46","article-title":"Cortical hand representation estimated by electrical and mechanical stimulated 96-channel SEP.","volume":"113","author":"Kawohl","year":"2002"},{"key":"b16","series-title":"Proc Natl Acad Sci USA","first-page":"5675","article-title":"Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.","volume":"89","author":"Kwong","year":"1992"},{"key":"b17","series-title":"J Magn Reson Imaging","first-page":"565","article-title":"Functional MRI in human somatosensory cortex activated by touching textured surfaces.","volume":"6","author":"Lin","year":"1996"},{"key":"b18","series-title":"Electromyography in Practice and Clinical Neurophysiology.","author":"Ludin","year":"1980"},{"key":"b19","series-title":"Lancet","first-page":"1300","article-title":"Functional sensibility of the hand after nerve repair.","volume":"20","author":"Lundborg","year":"1993"},{"key":"b20","series-title":"Neuroscience","first-page":"33","article-title":"Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation.","volume":"8","author":"Merzenich","year":"1983"},{"key":"b21","series-title":"J Bone Joint Surg Br","first-page":"454","article-title":"Objective methods for determining the functional value of sensibility in the hand.","volume":"40","author":"Moberg","year":"1958"},{"key":"b22","series-title":"Proc Natl Acad Sci USA","first-page":"3593","article-title":"Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography.","volume":"90","author":"Mogilner","year":"1993"},{"key":"b23","series-title":"Electroencephalogr Clin Neurophysiol","first-page":"6","article-title":"IFCN recommended standards for short latency somatosensory evoked potentials. Report of an IFCN committe. International Federation of Clinical Neurophysiology.","volume":"91","author":"Nuwer","year":"1994"},{"key":"b24","series-title":"Proc Natl Acad Sci USA","first-page":"5951","article-title":"Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.","volume":"89","author":"Ogawa","year":"1992"},{"key":"b25","series-title":"Neuropsychologia","first-page":"97","article-title":"The assessment and analysis of handedness: the Edinburgh inventory.","volume":"9","author":"Oldfield","year":"1971"},{"key":"b26","series-title":"Acta Chir Scand Suppl","first-page":"1","article-title":"Recovery of sensibility and sudomotor activity in the hand after nerve suture.","volume":"300","author":"\u00d6nne","year":"1962"},{"key":"b27","series-title":"J Neurosurg","first-page":"262","article-title":"Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization.","volume":"83","author":"Puce","year":"1995"},{"key":"b28","series-title":"AJNR","first-page":"567","article-title":"Location of hand function in the sensorimotor cortex: MR and functional correlation.","volume":"15","author":"Rumeau","year":"1994"},{"key":"b29","series-title":"J Neurosci","first-page":"4417","article-title":"Perceptual correlates of changes in cortical representation of fingers in blind multifinger Braille readers.","volume":"18","author":"Sterr","year":"1998"},{"key":"b30","series-title":"Nerves and Nerve Injuries.","author":"Sunderland","year":"1978"},{"key":"b31","series-title":"J Neurosci","first-page":"3456","article-title":"Changes in the cortical map of the hand following postnatal ulnar and radial nerve injury in monkeys: organization and modification of nerve dominance aggregates.","volume":"12","author":"Wall","year":"1992"},{"key":"b32","series-title":"J Neurosci","first-page":"218","article-title":"Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans.","volume":"6","author":"Wall","year":"1986"},{"key":"b33","series-title":"Neurosurgery","first-page":"921","article-title":"Functional magnetic resonance imaging mapping of the sensorimotor cortex with tactile stimulation.","volume":"36","author":"Yetkin","year":"1995"},{"key":"b34","series-title":"Brain","first-page":"141","article-title":"Localization of the motor hand area to a knob on the precentral gyrus. A new landmark.","volume":"120","author":"Yousry","year":"1997"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/99\/1\/article-p100.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/99\/1\/article-p100.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/99\/1\/article-p100.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T19:20:16Z","timestamp":1679253616000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/99\/1\/article-p100.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":34,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.2003.99.1.0100","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}