{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:18:00Z","timestamp":1791289080876,"version":"4.3.0"},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> In this study the authors evaluated the safety and performance of the GliaSite Radiation Therapy System (RTS) in patients with recurrent malignant brain tumors who were undergoing tumor resection.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> The GliaSite is an inflatable balloon catheter that is placed in the resection cavity at the time of tumor debulking. Low-dose-rate radiation is delivered with an aqueous solution of organically bound iodine-125 (Iotrex [sodium 3-(<jats:sup>125<\/jats:sup>I)-iodo-4-hydroxybenzenesulfonate]), which are temporarily introduced into the balloon portion of the device via a subcutaneous port. Adults with recurrent malignant glioma underwent resection and GliaSite implantation. One to 2 weeks later, the device was filled with Iotrex for 3 to 6 days, following which the device was explanted. Twenty-one patients with recurrent high-grade astrocytomas were enrolled in the study and received radiation therapy. There were two end points: 1) successful implantation and delivery of brachytherapy; and 2) safety of the device.<\/jats:p>\n<jats:p content-type=\"fine-print\">Implantation of the device, delivery of radiation, and the explantation procedure were well tolerated. At least 40 to 60 Gy was delivered to all tissues within the target volume. There were no serious adverse device-related events during brachytherapy. One patient had a pseudomeningocele, one patient had a wound infection, and three patients had meningitis (one bacterial, one chemical, and one aseptic). No symptomatic radiation necrosis was identified during 21.8 patient-years of follow up. The median survival of previously treated patients was 12.7 months (95% confidence interval 6.9\u201315.3 months).<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> The GliaSite RTS performs safely and efficiently. It delivers a readily quantifiable dose of radiation to tissue at the highest risk for tumor recurrence.<\/jats:p>","DOI":"10.3171\/jns.2003.99.2.0297","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:53:44Z","timestamp":1242237224000},"page":"297-303","source":"Crossref","is-referenced-by-count":105,"title":["An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trial"],"prefix":"10.3171","volume":"99","author":[{"given":"Stephen B.","family":"Tatter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kastytis C.","family":"Karvelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Kleinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Weingart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Crocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Brem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Pearlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy D.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Nucl Med","first-page":"631","article-title":"Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors.","volume":"40","author":"Akabani","year":"1999"},{"key":"b2","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1213","article-title":"Brachytherapy for recurrent malignant astrocytoma.","volume":"30","author":"Bernstein","year":"1994"},{"key":"b3","series-title":"J Clin Oncol","first-page":"3862","article-title":"Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas.","volume":"18","author":"Cokgor","year":"2000"},{"key":"b4","series-title":"Int J Radiat Oncol Biol Phys","first-page":"421","article-title":"Dosimetric properties of a novel brachytherapy balloon applicator for the treatment of malignant brain-tumor resection-cavity margins.","volume":"42","author":"Dempsey","year":"1998"},{"key":"b5","series-title":"Acta Neurochir","first-page":"127","article-title":"Intracavity fractionated balloon brachytherapy in glioblastoma.","volume":"141","author":"Johannesen","year":"1999"},{"key":"b6","series-title":"J Am Stat Assoc","first-page":"457","article-title":"Nonparametric estimation from incomplete observations.","volume":"53","author":"Kaplan","year":"1958"},{"key":"b7","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1005","article-title":"Randomized study of brachytherapy in the initial management of patients with malignant astrocytoma.","volume":"41","author":"Laperriere","year":"1998"},{"key":"b8","series-title":"Int J Radiat Oncol Biol Phys","first-page":"79","article-title":"Patterns of failure following high-dose 3-D conformal radiotherapy for high-grade astrocytomas: a quantitative dosimetric study.","volume":"43","author":"Lee","year":"1999"},{"key":"b9","series-title":"Radiation Injury to the Nervous System.","first-page":"257","article-title":"Factors affecting radiation injury after interstitial brachytherapy for brain tumors","author":"Leibel","year":"1991"},{"key":"b10","series-title":"Int J Radiat Oncol Biol Phys","first-page":"419","article-title":"Dose inhomogeneity in interstitial implants using 125I seeds.","volume":"5","author":"Ling","year":"1979"},{"key":"b11","series-title":"Neurosurg Clin N Am","first-page":"801","article-title":"Interstitial brachytherapy.","volume":"1","author":"McDermott","year":"1990"},{"key":"b12","series-title":"Med Phys","first-page":"73","article-title":"Experimental validation of dose calculation algorithms for the GliaSite RTS, a novel 125I liquid-filled balloon brachytherapy applicator.","volume":"28","author":"Monroe","year":"2001"},{"key":"b13","series-title":"Int J Radiat Oncol Biol Phys","first-page":"593","article-title":"Interstitial brachytherapy for newly diagnosed patients with malignant gliomas: the UCSF experience.","volume":"24","author":"Prados","year":"1992"},{"key":"b14","series-title":"Med Dosim","first-page":"217","article-title":"Dosimetry of I-125 seeds implanted on the surface of a cavity.","volume":"15","author":"Prasad","year":"1990"},{"key":"b15","series-title":"J Clin Oncol","first-page":"1389","article-title":"Phase II trial of murine 131I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas.","volume":"20","author":"Reardon","year":"2002"},{"key":"b16","series-title":"Int J Radiat Oncol Biol Phys","first-page":"887","article-title":"Dosimetric considerations of stereotactic brain implants.","volume":"17","author":"Saw","year":"1989"},{"key":"b17","series-title":"Int J Radiat Oncol Biol Phys","first-page":"583","article-title":"High activity iodine-125 interstitial implant for gliomas.","volume":"24","author":"Scharfen","year":"1992"},{"key":"b18","series-title":"Int J Radiat Oncol Biol Phys","first-page":"719","article-title":"Patterns of recurrence of glioblastoma multiforme after external irradiation followed by implant boost.","volume":"29","author":"Sneed","year":"1994"},{"key":"b19","series-title":"Int J Radiat Oncol Biol Phys","first-page":"37","article-title":"Demonstration of brachytherapy boost dose-response relationships in glioblastoma multiforme.","volume":"35","author":"Sneed","year":"1996"},{"key":"b20","series-title":"Semin Surg Oncol","first-page":"157","article-title":"Interstitial brachytherapy procedures for brain tumors.","volume":"13","author":"Sneed","year":"1997"},{"key":"b21","series-title":"J Neurosurg","first-page":"335","article-title":"Preclinical evaluation of a novel device for delivering brachytherapy to the margins of resected brain tumor cavities.","volume":"96","author":"Stubbs","year":"2002"},{"key":"b22","series-title":"Cancer Biother Radiopharm","first-page":"645","article-title":"Biodistribution and dosimetry of an aqueous solution containing sodium 3-(125I)iodo-4-hydroxybenzenesulfonate (Iotrex) for brachytherapy of resected malignant brain tumors.","volume":"15","author":"Stubbs","year":"2000"},{"key":"b23","series-title":"Int J Radiat Oncol Biol Phys","first-page":"687","article-title":"Use of the RTOG recursive partitioning analysis to validate the benefit of iodine-125 implants in the primary treatment of malignant gliomas.","volume":"45","author":"Videtic","year":"1999"},{"key":"b24","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1405","article-title":"Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma.","volume":"16","author":"Wallner","year":"1989"},{"key":"b25","series-title":"Cancer","first-page":"3029","article-title":"Long term results of stereotactic brachytherapy used in the initial treatment of patients with glioblastomas.","volume":"73","author":"Wen","year":"1994"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/99\/2\/article-p297.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/99\/2\/article-p297.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/99\/2\/article-p297.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T23:53:41Z","timestamp":1679270021000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/99\/2\/article-p297.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":25,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.2003.99.2.0297","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}