{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:55:03Z","timestamp":1695887703634},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,8]]},"abstract":"\u2713 The authors report on two gonadotropic carcinomas of the adenohypophysis that occurred in a 55-year-old man (Case 1) and a 53-year-old woman (Case 2), with signs of mass effect and amenorrhea, respectively. Both lesions were macroadenomas. The tumor in Case 1 metastasized to dura mater, skull, nasal sinus, and larynx 2 years after patient presentation, whereas that in Case 2 spread to vertebral bodies and ribs after a 19-year latency. Histologically, the primary, recurrent, and metastatic lesions in Case 1 featured brisk mitotic activity and high MIB-1 levels as well as p53 labeling indices. Immunoreactivity for HER-2\/neu<\/jats:italic> was assessable only in rare neoplastic cells of the second recurrence and in 80% of cells of the dural metastasis. Low-level HER-2\/neu<\/jats:italic> gene amplification was evident in the recurrent tumors and metastasis. The sellar and metastatic tumors in Case 2 resembled benign gonadotropic adenoma with oncocytic change; p53 accumulation, HER-2\/neu overexpression, and HER-2\/neu<\/jats:italic> gene amplification were not present. The results indicate that low-level amplification of the HER-2\/neu<\/jats:italic> gene might be associated with pituitary carcinomas in which more aggressive behavior is seen. Further studies are needed to determine whether HER-2\/neu<\/jats:italic> plays a role in the pathogenesis of pituitary carcinoma.<\/jats:p>","DOI":"10.3171\/jns.2003.99.2.0402","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:53:44Z","timestamp":1242237224000},"page":"402-408","source":"Crossref","is-referenced-by-count":32,"title":["Gonadotropic pituitary carcinoma: HER-2\/neu expression and gene amplification"],"prefix":"10.3171","volume":"99","author":[{"given":"Federico","family":"Roncaroli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vania","family":"Nos\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd W.","family":"Scheithauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalman","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo V.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary C.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Hsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Nature","first-page":"226","article-title":"The neu oncogene encodes an epidermal growth factor receptor-related protein.","volume":"319","author":"Bargmann","year":"1986"},{"key":"b2","series-title":"Neurosurgery","first-page":"810","article-title":"Gonadotropic pituitary carcinoma: case report.","volume":"37","author":"Beauchesne","year":"1995"},{"key":"b3","series-title":"J Biol Chem","first-page":"12449","article-title":"Role of p53 in HER2-induced proliferation and apoptosis.","volume":"276","author":"Casalini","year":"2001"},{"key":"b4","series-title":"Endocrinology","first-page":"2012","article-title":"Expression of epidermal growth factor (EGF), its receptor, and related oncoprotein (erbB-2) in human pituitary tumors and response to EGF in vitro.","volume":"135","author":"Chaidarun","year":"1994"},{"key":"b5","series-title":"Science","first-page":"1132","article-title":"Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.","volume":"230","author":"Coussens","year":"1985"},{"key":"b6","series-title":"Clin Endocrinol","first-page":"599","article-title":"The c-erbB-2\/neu proto-oncogene in human pituitary tumours.","volume":"46","author":"Ezzat","year":"1997"},{"key":"b7","series-title":"Brain Pathol","first-page":"67","article-title":"Fluorescence in situ hybridization (FISH) in diagnostic and investigative neuropathology.","volume":"12","author":"Fuller","year":"2002"},{"key":"b8","series-title":"Semin Oncol","first-page":"51","article-title":"Basic science of HER-2\/neu: a review.","volume":"26","author":"Hung","year":"1999"},{"key":"b9","series-title":"Neurosurgery","first-page":"1233","article-title":"Pituitary carcinoma containing gonadotropins: treatment by radical excision and cytotoxic chemotherapy: case report.","volume":"46","author":"McCutcheon","year":"2000"},{"key":"b10","series-title":"Semin Oncol","first-page":"108","article-title":"The role of immunohistochemistry and fluorescence in situ hybridization for HER2\/neu in assessing the prognosis of breast cancer.","volume":"26","author":"Mitchell","year":"1999"},{"key":"b11","series-title":"Endocr Pathol","first-page":"53","article-title":"Adrenocorticotropin-producing pituitary carcinoma with expression of c-erbB-2 and high PCNA index. A comparative study with pituitary adenomas and normal pituitary tissues.","volume":"9","author":"Nos\u00e9-Alberti","year":"1998"},{"key":"b12","series-title":"Br J Neurosurg","first-page":"211","article-title":"Intracranial metastases from pituitary adenoma.","volume":"9","author":"O'Brien","year":"1995"},{"key":"b13","series-title":"Diagnosis and Management of Pituitary Tumors.","first-page":"369","article-title":"Invasive pituitary adenoma and pituitary carcinoma","author":"Pernicone","year":"2001"},{"key":"b14","series-title":"Cancer","first-page":"804","article-title":"Pituitary carcinoma: a clinicopathologic study of 15 cases.","volume":"79","author":"Pernicone","year":"1997"},{"key":"b15","series-title":"Ultrastruct Pathol","first-page":"227","article-title":"Pituitary carcinoma: an ultrastructural study of eleven cases.","volume":"25","author":"Scheithauer","year":"2001"},{"key":"b16","series-title":"Mayo Clin Proc","first-page":"649","article-title":"Gonadotroph adenoma of the pituitary gland: a clinicopathologic analysis of 100 cases.","volume":"71","author":"Young","year":"1996"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/99\/2\/article-p402.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/99\/2\/article-p402.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/99\/2\/article-p402.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T23:54:26Z","timestamp":1679270066000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/99\/2\/article-p402.xml"}},"subtitle":["Report of two cases"],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":16,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.2003.99.2.0402","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}