{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:57:09Z","timestamp":1784055429539,"version":"3.55.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> Craniovertebral junction malformation (CVJM) or Chiari malformation in adults, with or without syringomyelia and basilar invagination, produces neuronal dysfunction of the brainstem, cerebellum, cranial nerves, and upper spinal cord. The respiratory center and some of its afferent and efferent components can be altered in these diseases. The authors studied patients with and without CVJM to determine whether this physical feature contributed to sleep disturbances.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Respiratory manifestations during sleep were studied prospectively, by using whole-night polysomnography, in 32 symptomatic patients (CVJM group) and 16 healthy volunteers (control group). Patients with CVJM presented with more sleep disturbances (reports of snoring and apnea) than those in the control group. The apnea\/hypopnea index values were higher in patients with CVJMs than in the control group (13 \u00b1 15 compared with 3 \u00b1 6; p = 0.007) and the rate of central sleep apneas was higher in the CVJM than in the control group (22 \u00b1 30 compared with 4 \u00b1 8%; p = 0.009). The apnea\/hypopnea index was highest in the subgroup with basilar invagination than in the other subgroups. The central apneic episodes were more frequent in the patients with basilar invagination (35 \u00b1 40%; p = 0.001) and in those with syringomyelia (17.6 \u00b1 24.6%; p = 0.003) than in the control group (4 \u00b1 8%). Patients with symptomatic CVJM, especially those with basilar invagination, presented with more sleep respiratory compromise than did those in the control group.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> The incidence of sleep apnea\/hypopnea syndrome is significantly higher in patients with CVJM.<\/jats:p>","DOI":"10.3171\/jns.2003.99.6.1004","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:49:07Z","timestamp":1242236947000},"page":"1004-1009","source":"Crossref","is-referenced-by-count":51,"title":["A prospective controlled study of sleep respiratory events in patients with craniovertebral junction malformation"],"prefix":"10.3171","volume":"99","author":[{"given":"Ricardo Vieira","family":"Botelho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Rita Azeredo","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Marcos","family":"Rotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Comput Assist Tomogr","first-page":"1033","article-title":"Position of cerebellar tonsils in the normal population and in patients with Chiari malformation: a quantitative approach with MRI imaging.","volume":"9","author":"Aboulezz","year":"1985"},{"issue":"(1)","key":"b2","series-title":"Neurosurg Focus","article-title":"Analysis of magnetic resonance imaging-based blood and cerebrospinal fluid flow measurements in patients with Chiari I malformation: a system approach.","volume":"11","author":"Alperin","year":"2001"},{"key":"b3","series-title":"Sleep","first-page":"667","article-title":"Sleep related breathing disorders in adults: recommendations for syndrome definitions and measurements techniques in clinical research. 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