{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:13:15Z","timestamp":1792804395258,"version":"4.5.0"},"reference-count":43,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713\u2713 Based on the results of thalamotomies described by Hassler in 1970, the authors performed bilateral thalamic highfrequency stimulation (HFS) in three patients with intractable Tourette syndrome (TS). In this report they describe the long-term effects.<\/jats:p>\n<jats:p content-type=\"fine-print\">Three male patients (42, 28, and 45 years of age) had manifested motor and vocal tics since early childhood. The diagnosis of TS was made according to the criteria of the Tourette Syndrome Classification Study Group. Any drug or alternative treatment had been either ineffective or only temporarily effective in all three patients. There was no serious comorbidity. The target for stimulation was chosen at the level of the centromedian nucleus, substantia periventricularis, and nucleus ventrooralis internus. After 2 weeks of test stimulation, the pulse generators were implanted. After a follow-up period of 5 years in the patient in Case 1, 1 year in the patient in Case 2, and 8 months in the patient in Case 3, all major motor and vocal tics had disappeared and no serious complications had occurred. When stimulation was applied at the voltage necessary to achieve an optimal result on the tics, a slight sedative effect was noted in all three patients. In the patients in Cases 1 and 3 there were stimulation-induced changes in sexual behavior.<\/jats:p>\n<jats:p content-type=\"fine-print\">Chronic thalamic HFS may be an effective and safe treatment for medically intractable TS in adult patients. Unwanted stimulation-induced side effects may occur.<\/jats:p>","DOI":"10.3171\/jns.2003.99.6.1094","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:49:07Z","timestamp":1242236947000},"page":"1094-1100","source":"Crossref","is-referenced-by-count":220,"title":["Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome"],"prefix":"10.3171","volume":"99","author":[{"given":"Veerle","family":"Visser-Vandewalle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Temel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Vreeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Colle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govert","family":"Hoogland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk J.","family":"Groenewegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"van der Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Ann Rev Neurosci","first-page":"357","article-title":"Parallel organization of functionally segregated circuits linking basal ganglia and cortex.","volume":"9","author":"Alexander","year":"1986"},{"key":"b2","series-title":"Acta Paedopsychiatr","first-page":"39","article-title":"Gilles de la Tourette-Syndrom und Psychochirurgie.","volume":"47","author":"Asam","year":"1981"},{"key":"b3","series-title":"J Neurol Neurosurg Psychiatry","first-page":"666","article-title":"Immediate and long term outcome after infrathalamic and thalamic lesioning for intractable Tourette's syndrome.","volume":"70","author":"Babel","year":"2001"},{"key":"b4","series-title":"Arch Gen Psychiatry","first-page":"384","article-title":"Cingulotomy for intractable obsessive-compulsive disorder. Prospective long-term follow-up of 18 patients.","volume":"52","author":"Baer","year":"1995"},{"key":"b5","series-title":"Can Med Assoc J","first-page":"746","article-title":"Gilles de la Tourette syndrome treated by bimedial frontal leucotomy.","volume":"86","author":"Baker","year":"1962"},{"key":"b6","series-title":"Arch Psychiatr Nervenkr","first-page":"169","article-title":"Zur Gilles de la Touretteschen Erkrankung anhand von funfeigenen Beobachtungen.","volume":"217","author":"Beckers","year":"1973"},{"key":"b7","series-title":"Neuropsychopharmacology","first-page":"277","article-title":"The functional neuroanatomy of Tourette's syndrome: an FDG-PET study. I. Regional changes in cerebral glucose metabolism differentiating patients and controls.","volume":"9","author":"Braun","year":"1993"},{"key":"b8","series-title":"Acta Neurol","first-page":"273","article-title":"Surgical stereotactic treatment for Gilles de la Tourette's syndrome.","volume":"9","author":"Cappabianca","year":"1987"},{"key":"b9","series-title":"Arch Neurol","first-page":"132","article-title":"Dystonia reversal by operation on basal ganglia.","volume":"7","author":"Cooper","year":"1962"},{"key":"b10","series-title":"Involuntary Movement Disorders.","first-page":"274","author":"Cooper","year":"1969"},{"key":"b11","series-title":"Biol Psychiatry","first-page":"1117","article-title":"Gilles de la Tourette syndrome and the neurological basis of obsessions and compulsions.","volume":"20","author":"Cummings","year":"1985"},{"key":"b12","series-title":"Mov Disord","first-page":"693","article-title":"Home alone: methods to maximize tic expression for objective videotape assessments in Gilles de la Tourette syndrome.","volume":"16","author":"Goetz","year":"2001"},{"key":"b13","series-title":"Adv Neurol","first-page":"123","article-title":"The neurobiology of repetitive behaviors: clues to the neurobiology of Tourette syndrome.","volume":"85","author":"Graybiel","year":"2001"},{"key":"b14","series-title":"Neuron","first-page":"343","article-title":"Toward a neurobiology of obsessive-compulsive disorder.","volume":"28","author":"Graybiel","year":"2000"},{"key":"b15","series-title":"Trends Neurosci","first-page":"52","article-title":"The specificity of the \u201cnonspecific\u201d midline and intralaminar thalamic nuclei.","volume":"17","author":"Groenewegen","year":"1994"},{"key":"b16","series-title":"Stereotaxy of the Human Brain","first-page":"570","article-title":"Stereotaxic surgery for psychiatric disturbances","author":"Hassler","year":"1982"},{"key":"b17","series-title":"Surgical Approaches in Psychiatry. Proceedings of the Third International Congress of Psychosurgery.","first-page":"206","article-title":"Relief of obsessive-compulsive disorders, phobias and tics by stereotactic coagulations of the rostral intralaminar and medial-thalamic nuclei","author":"Hassler","year":"1973"},{"key":"b18","series-title":"Rev Neurol","first-page":"89","article-title":"Traitement stereotaxique des tics et cris inarticul\u00e9s ou coprolaliques consid\u00e9r\u00e9s comme ph\u00e9nom\u00e8ne d'obsession motrice au cours de la maladie de Gilles de la Tourette.","volume":"123","author":"Hassler","year":"1970"},{"key":"b19","series-title":"N Engl J Med","first-page":"1184","article-title":"Tourette's syndrome.","volume":"345","author":"Jankovic","year":"2001"},{"key":"b20","series-title":"Neurology","first-page":"203","article-title":"Surgical treatment of severe obsessive-compulsive disorder associated with Tourette syndrome.","volume":"38","author":"Kurlan","year":"1988"},{"key":"b21","series-title":"Mov Disord","first-page":"152","article-title":"Neurosurgical treatment of severe obsessive-compulsive disorder associated with Tourette's syndrome.","volume":"5","author":"Kurlan","year":"1990"},{"key":"b22","series-title":"Neurology","first-page":"890","article-title":"Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome.","volume":"43","author":"Leckman","year":"1993"},{"key":"b23","series-title":"Adv Neurol","first-page":"15","article-title":"Pathogenesis of Tourette syndrome. Clues from the clinical phenotype and natural history.","volume":"58","author":"Leckman","year":"1992"},{"key":"b24","series-title":"Neurology","first-page":"514","article-title":"The mysterious motor function of the basal ganglia: the Robert Wartenberg Lecture.","volume":"32","author":"Marsden","year":"1982"},{"key":"b25","series-title":"Pediatr Neurol","first-page":"190","article-title":"Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis.","volume":"25","author":"Mink","year":"2001"},{"key":"b26","series-title":"Prog Neurobiol","first-page":"381","article-title":"The basal ganglia: focused selection and inhibition of competing motor programs.","volume":"50","author":"Mink","year":"1996"},{"key":"b27","series-title":"J Nerv Ment Dis","first-page":"282","article-title":"Multiple tic syndrome (Giles de la Tourette's syndrome).","volume":"159","author":"Moldofsky","year":"1974"},{"key":"b28","series-title":"Confin Neurol","first-page":"320","article-title":"Experiences with dentatotomy.","volume":"34","author":"Nadvornik","year":"1972"},{"key":"b29","series-title":"Neurology","first-page":"941","article-title":"Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images.","volume":"43","author":"Peterson","year":"1993"},{"key":"b30","series-title":"Adv Neurol","first-page":"207","article-title":"Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods.","volume":"85","author":"Rauch","year":"2001"},{"key":"b31","series-title":"Neuroscience","first-page":"1009","article-title":"The basal ganglia: a vertebrate solytion to the selection problem?","volume":"89","author":"Redgrave","year":"1999"},{"key":"b32","series-title":"J Neurol Neurosurg Psychiatry","first-page":"691","article-title":"The treatment of Gilles de la Tourette syndrome by limbic leucotomy.","volume":"53","author":"Robertson","year":"1990"},{"key":"b33","series-title":"Brain","first-page":"425","article-title":"Tourette syndrome, associated conditions and the complexities of treatment.","volume":"123","author":"Robertson","year":"2000"},{"key":"b34","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1016","article-title":"The metabolic effects of limbic leucotomy in Gilles de la Tourette syndrome.","volume":"56","author":"Sawle","year":"1993"},{"key":"b35","series-title":"Ann Neurol","first-page":"361","article-title":"Dopaminergic dysfunction in Tourette syndrome.","volume":"12","author":"Singer","year":"1982"},{"key":"b36","series-title":"Neurosci Biobehav Rev","first-page":"507","article-title":"Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications.","volume":"24","author":"Steers","year":"2000"},{"key":"b37","series-title":"Med Amm DC","first-page":"277","article-title":"The syndrome of Gilles de la Tourette and its treatment: report of a case.","volume":"36","author":"Stevens","year":"1964"},{"key":"b38","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1","article-title":"Neurological features of Gilles de la Tourette's syndrome.","volume":"36","author":"Sweet","year":"1973"},{"key":"b39","series-title":"Arch Neurol","first-page":"1013","article-title":"Definitions and classification of tic disorders.","volume":"50","year":"1993"},{"key":"b40","series-title":"Brain Res Brain Res Rev","first-page":"107","article-title":"The intralaminar and midline nuclei of the thalamus. 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