{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:31:47Z","timestamp":1772915507444,"version":"3.50.1"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The author presents a large series of patients with idiopathic trigeminal neuralgia (TN) who were treated with gamma knife surgery (GKS), at a maximum dose of 75 to 76.8 Gy, and followed up in a nearly uniform manner for up to 4.6 years.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Two hundred ninety-three patients were treated and followed up for at least 6 months (range 0.4\u20134.6 years, median 1.9 years). At the final follow-up review, there was complete (100%) pain relief without medicines in 64 patients (21.8%), 90% or greater relief with or without small doses of medicines in 86 (29.4%), between 75 and 89% relief in 31 (10.6%), between 50 and 74% relief in 19 (6.5%), and less than 50% relief in 23 patients (7.8%). Recurrent pain requiring a second procedure occurred in 70 patients (23.9%). Kaplan\u2014Meier analysis showed that 100%, 90% or greater, and 50% or greater pain relief was obtained and maintained for 3.5 to 4.1 years in 5.6 , 23.7, and 50.4% patients, respectively. Of 31 patients who described pain relief ranging from 75 to 89%, 80% of patients described it as good and 10% as excellent; of 17 patients who reported between 50 and 74% pain relief, 53% described it as good and none as excellent (p = 0.014). Dysesthesia scores greater than 5 (scale of 0\u201310, in which a score of 10 represents excruciating pain) occurred in four (3.2%) of 126 patients who had not undergone prior surgery; all these patients obtained either good or excellent relief from TN pain. There were 36 patients in whom the TN had atypical features; these patients were less likely to attain at least 50% or at least 90% pain relief compared with those without atypical TN features (p = 0.001).<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> Gamma knife surgery is a safe and effective way to relieve TN. Patients who attain between 75 and 89% pain relief are much more likely to describe this outcome as good or excellent than those who attain between 50 and 74% pain relief.<\/jats:p>","DOI":"10.3171\/jns.2004.100.5.0848","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:57:45Z","timestamp":1242237465000},"page":"848-854","source":"Crossref","is-referenced-by-count":70,"title":["Gamma knife surgery with a dose of 75 to 76.8 Gray for trigeminal neuralgia"],"prefix":"10.3171","volume":"100","author":[{"given":"Ronald","family":"Brisman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604253341701"},{"key":"b2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3171\/jns.2000.93.supplement_3.0159","volume":"93","author":"Brisman R","year":"2000","journal-title":"J Neurosurg"},{"key":"b3","first-page":"1261","volume":"50","author":"Brisman R","year":"2002","journal-title":"Neurosurgery"},{"key":"b4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3171\/jns.2000.93.supplement_3.0155","volume":"93","author":"Brisman R","year":"2000","journal-title":"J Neurosurg"},{"key":"b5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000056476","volume":"74","author":"Chang JW","year":"2000","journal-title":"Stereotact Funct Neurosurg"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01606-6"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(02)00993-X"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(84)90005-3"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.6.0940"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.94.1.0014"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.90.1.0001"},{"key":"b12","first-page":"58","volume":"49","author":"Pollock BE","year":"2001","journal-title":"Neurosurgery"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.2.0347"},{"key":"b14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1042-3680(18)30201-8","volume":"10","author":"Regis J","year":"1999","journal-title":"Neurosurg Clin N Am"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(96)00187-5"},{"key":"b16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3171\/jns.2000.93.2.0169","volume":"93","author":"Worthington C","year":"2000","journal-title":"J Neurosurg"},{"key":"b17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000056422","volume":"70","author":"Young RF","year":"1998","journal-title":"Sterotact Funct Neurosurg"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/100\/5\/article-p848.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/100\/5\/article-p848.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/100\/5\/article-p848.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T03:12:53Z","timestamp":1653707573000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/100\/5\/article-p848.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":17,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.2004.100.5.0848","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}