{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:35:11Z","timestamp":1791275711130,"version":"4.1.0"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic>Endothelin-1 (ET-1) is one of the major inducers of vasospasm following subarachnoid hemorrhage (SAH). It is generally accepted that extracellular signal\u2014regulated kinase 1 and 2 (ERK1\/2) are involved in ET-1\u2014induced vascular contraction. In addition, ET-1 transactivates epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK), which leads to ERK1\/2 stimulation. Therefore, the authors examined whether EGFR\u2014PTK transactivation contributes to ET-1\u2014induced vascular contraction in this study.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic>Mitogen-activated protein kinase inhibitor, PD98059, inhibited ET-1\u2014induced ERK1\/2 stimulation in rabbit basilar artery (BA) vascular smooth-muscle cells (VSMCs). Moreover, PD98059 inhibited ET-1\u2014induced contraction of rabbit BA rings. A specific inhibitor of EGFR PTK, AG1478, inhibited ET-1\u2014induced EGFR\u2014PTK transactivation, ERK1\/2 stimulation, and contraction of BA rings in a concentration-dependent manner. The concentration of AG1478 required for 50% inhibition of the ET-1\u2014induced contraction of BA rings was similar to that for ET-1\u2014induced EGFR\u2014PTK transactivation. Furthermore, AG1478 also inhibited ET-1\u2014induced BA vasospasm in vivo.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Conclusion.<\/jats:italic>The results indicate that EGFR\u2014PTK transactivation pathway plays an important role in ET-1\u2014induced vascular contraction.<\/jats:p>","DOI":"10.3171\/jns.2004.100.6.1066","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T17:55:23Z","timestamp":1242237323000},"page":"1066-1071","source":"Crossref","is-referenced-by-count":20,"title":["Involvement of epidermal growth factor receptor\u2014protein tyrosine kinase transactivation in endothelin-1\u2014induced vascular contraction"],"prefix":"10.3171","volume":"100","author":[{"given":"Yoshifumi","family":"Kawanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoh","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0967-5868(94)90021-3","volume":"1","author":"Dorsch NWC","year":"1994","journal-title":"J Clin Neurosci"},{"key":"b2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1096\/fj.02-0115fje","volume":"17","author":"Flamant M","year":"2003","journal-title":"FASEB J"},{"key":"b3","first-page":"H976","volume":"276","author":"Florian JA","year":"1999","journal-title":"Am J Physiol"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.3.0503"},{"key":"b5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0014-2999(02)01790-9","volume":"445","author":"Ishihata A","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"b6","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1210\/endo.140.10.7023","volume":"140","author":"Iwasaki H","year":"1999","journal-title":"Endocrinology"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200209000-00013"},{"key":"b8","doi-asserted-by":"crossref","first-page":"H2671","DOI":"10.1152\/ajpheart.00350.2002","volume":"283","author":"Kawanabe Y","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"b9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00005344-200208000-00016","volume":"40","author":"Kawanabe Y","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.3.0561"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199009000-00003"},{"key":"b12","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1006\/bbrc.1993.1560","volume":"192","author":"Merkel LA","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.85.5.0846"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.6.0992"},{"key":"b15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0026-895X(25)08731-0","volume":"49","author":"Sugawara F","year":"1996","journal-title":"Mol Pharmacol"},{"key":"b16","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0022-3565(25)21317-9","volume":"279","author":"Watts SW","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"b17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0022-3565(24)36792-8","volume":"282","author":"Zheng XL","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199810000-00083"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/100\/6\/article-p1066.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/100\/6\/article-p1066.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/100\/6\/article-p1066.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T11:36:33Z","timestamp":1739100993000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/100\/6\/article-p1066.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":18,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/jns.2004.100.6.1066","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}