{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:36:46Z","timestamp":1771069006647,"version":"3.50.1"},"reference-count":33,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> Balloon occlusion tests (BOTs) are performed to identify patients who are at risk for ischemia and stroke following permanent internal carotid artery (ICA) occlusion. The object of this work was to determine whether patient-specific blood flow modeling can be used to identify patients in whom the BOT would not be tolerated.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> The test was performed in 16 patients who underwent BOT with continuous neurological and electroencephalographic monitoring, followed by a hypotensive challenge. During hypotension a tracer was injected so that single-photon emission tomography (SPECT) scans could be obtained. Each individual brain circulation was modeled using information gained from phase-contrast magnetic resonance (MR) angiography and digital subtraction (DS) angiography, and the predicted effect of the BOT was evaluated.<\/jats:p>\n<jats:p content-type=\"fine-print\">Six patients did not tolerate the BOT; in these patients, decreases in middle cerebral artery (M<jats:sub>1<\/jats:sub> segment) blood flow of 41 \u00b1 27% (mean \u00b1 standard deviation), anterior cerebral artery (A<jats:sub>3<\/jats:sub> segment) flow of 56 \u00b1 33%, and posterior cerebral artery (P<jats:sub>2<\/jats:sub> segment) flow of 4 \u00b1 13% ipsilateral to the site of occlusion were found with modeling; these changes were significantly greater than the percentage of changes measured in the contralateral hemisphere (p &lt; 0.05). Ten patients who tolerated the BOT well had calculated decreases in ipsilateral flows of only 9 \u00b1 6% for the M<jats:sub>1<\/jats:sub> segment, 12 \u00b1 40% for the A<jats:sub>3<\/jats:sub> segment, and 17 \u00b1 21% for the P<jats:sub>2<\/jats:sub> segment during BOT modeling.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> A decrease in blood flow in both the ipsilateral M<jats:sub>1<\/jats:sub> and A<jats:sub>3<\/jats:sub> segments that was greater than 20%, calculated by flow modeling of the BOT, was 100% sensitive and 100% specific in identifying patients who could not tolerate the BOT. Blood flow modeling, coupled with DS angiography and noninvasive phase-contrast MR angiography measurements to make calculations patient specific, can be used to identify patients who have an elevated risk of ischemia during the BOT.<\/jats:p>","DOI":"10.3171\/jns.2004.101.6.0977","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:03:03Z","timestamp":1242237783000},"page":"977-988","source":"Crossref","is-referenced-by-count":38,"title":["A patient-specific computer model to predict outcomes of the balloon occlusion test"],"prefix":"10.3171","volume":"101","author":[{"given":"Fady 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