{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:03:18Z","timestamp":1787025798122,"version":"build-2736575974"},"reference-count":65,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p content-type=\"fine-print\">\n                    <jats:italic>Object.<\/jats:italic>\n                    The extended transsphenoidal approach, which requires a bone and dural opening through the tuberculum sellae and posterior planum sphenoidale, is increasingly used for the treatment of nonadenomatous suprasellar tumors. The authors present their experiences in using the direct endonasal approach in patients with nonadenomatous suprasellar tumors.\n                  <\/jats:p>\n                  <jats:p content-type=\"fine-print\">\n                    <jats:italic>Methods.<\/jats:italic>\n                    Surgery was performed with the aid of an operating microscope and angled endoscopes were used to assess the completeness of resection. Bone and dural defects were repaired using abdominal fat, collagen sponge, titanium mesh, and, in most cases, lumbar drainage of cerebrospinal fluid (CSF).\n                  <\/jats:p>\n                  <jats:p content-type=\"fine-print\">Twenty-six procedures for tumor removal were performed in 24 patients (ages 9\u201379 years), including two repeated operations for residual tumor. Gross-total removal could be accomplished in only 46% of patients, with near-gross-total removal or better in 74% of 23 patients (five of eight with craniopharyngiomas, six of seven with meningiomas, five of six with Rathke cleft cysts, and one of two with a dermoid or epidermoid cyst); a patient with a lymphoma only underwent biopsy. Of 13 patients with tumor-related visual loss, 85% improved postoperatively. The complications that occurred included five patients (21%) with postoperative CSF leaks, one patient (4%) with bacterial meningitis; five patients (21%) with new endocrinopathy; and two patients (8%) who needed to undergo repeated operations to downsize suprasellar fat grafts. The only permanent neurological deficit was anosmia in one patient; there were no intracranial vascular injuries.<\/jats:p>\n                  <jats:p content-type=\"fine-print\">\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    The direct endonasal skull-base approach provides an effective minimally invasive means for resecting or debulking nonadenomatous suprasellar tumors that have traditionally been approached through a sublabial or transcranial route. Procedures in the supraglandular space can be performed effectively with excellent visualization of the optic apparatus while preserving pituitary function in most cases. The major challenge remains developing consistently effective techniques to prevent postoperative CSF leaks.\n                  <\/jats:p>","DOI":"10.3171\/jns.2005.102.5.0832","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T14:04:15Z","timestamp":1242223455000},"page":"832-841","source":"Crossref","is-referenced-by-count":205,"title":["The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors"],"prefix":"10.3171","volume":"102","author":[{"given":"Joshua R.","family":"Dusick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Cohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"DeSalles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1227\/01.NEU.0000125542.00834.6D","article-title":"Large sphenoid wing meningiomas involving the cavernous sinus: conservative surgical strategies for better functional outcomes.","volume":"54","author":"Abdel-Aziz","year":"2004"},{"key":"b2","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1227\/00006123-198503000-00014","article-title":"Microsurgical removal of suprasellar meningiomas.","volume":"16","author":"Al-Mefty","year":"1985"},{"key":"b3","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0090-3019(99)00195-0","article-title":"Endoscopic-guided direct endonasal approach for pituitary surgery.","volume":"53","author":"Badie","year":"2000"},{"key":"b4","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1227\/00006123-198506000-00005","article-title":"Symptomatic Rathke's cleft cysts located entirely in the suprasellar region: review of diagnosis, management, and pathogenesis.","volume":"16","author":"Barrow","year":"1985"},{"key":"b5","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1227\/00006123-199007000-00008","article-title":"Loss of vision after transsphenoidal surgery.","volume":"27","author":"Barrow","year":"1990"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3171\/jns.1986.65.1.0022","article-title":"Surgical management of craniopharyngiomas. 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