{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T22:08:56Z","timestamp":1759183736924},"reference-count":13,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The purpose of this study was to evaluate the safety and efficacy of gamma knife surgery (GKS) for the treatment of arteriovenous malformations (AVMs) involving the corpus callosum.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Thirty-two patients aged from 7 to 65 years (median 25 years) with AVMs of the corpus callosum underwent GKS between 1990 and 2002. The maximum AVM diameter was more than 3 cm in 11 patients (34%). The AVM volume ranged from 0.1 to 19.1 cm<jats:sup>3<\/jats:sup> (median 1.6 cm<jats:sup>3<\/jats:sup>). The median dose to the AVM margin was 20 Gy (range 17\u201328 Gy). Patients were followed for 1 to 12 years (median 9 years). The angiographically confirmed actuarial obliteration rate was 64% and 74% at 4 and 6 years, respectively. Younger patient age (p &lt; 0.05) and lower radiosurgery-based grading score (calculated from the patient age and AVM volume; p &lt; 0.01) were the significant factors affecting successful AVM obliteration. No patient suffered a hemorrhage after GKS, although 28 patients (88%) had a history of hemorrhage from their AVMs. Radiation-induced neurological deficit was observed only in one patient (3%) who had undergone previous radiotherapy (50 Gy). No patient experienced complications of occlusion or stenosis of the normal vascular structures adjacent to the AVM.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> Gamma knife surgery is a safe and effective treatment for selected patients with AVMs involving the corpus callosum, and it carries a low risk of damaging adjacent critical vascular structures. Even ruptured AVMs with relatively large diameter can be successfully treated, especially in younger patients, with minimal morbidity and a low risk of repeated hemorrhage.<\/jats:p>","DOI":"10.3171\/jns.2005.102.s_supplement.0049","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T14:11:12Z","timestamp":1242223872000},"page":"49-52","source":"Crossref","is-referenced-by-count":14,"title":["Gamma knife surgery for arteriovenous malformations involving the corpus callosum"],"prefix":"10.3171","volume":"102","author":[{"given":"Keisuke","family":"Maruyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Kirino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/01616412.1982.11739626","volume":"4","author":"Guidetti B","year":"1982","journal-title":"Neurol Res"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.75.4.0512"},{"key":"b3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1227\/00006123-198406000-00018","volume":"14","author":"Machado de Almeida G","year":"1984","journal-title":"Neurosurgery"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.100.3.0407"},{"key":"b5","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2176\/nmc.36.851","volume":"36","author":"Picard L","year":"1996","journal-title":"Neurol Med Chir"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.1.0079"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199806000-00020"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.4.0779"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.1.0018"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.4.0476"},{"key":"b11","first-page":"14","volume-title":"Microneurosurgery.","author":"Yasargil MG","year":"1988"},{"key":"b12","first-page":"67","volume":"5","author":"Ya\u015fargil MG","year":"1976","journal-title":"Surg Neurol"},{"key":"b13","first-page":"5","volume":"5","author":"Ya\u015fargil MG","year":"1976","journal-title":"Surg Neurol"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/102\/11806\/article-p49.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/thejns.org\/doi\/pdf\/10.3171\/jns.2005.102.s_supplement.0049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T11:57:38Z","timestamp":1539345458000},"score":1,"resource":{"primary":{"URL":"http:\/\/thejns.org\/doi\/10.3171\/sup.2005.102.s_supplement.0049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":13,"URL":"https:\/\/doi.org\/10.3171\/jns.2005.102.s_supplement.0049","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}