{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:57:19Z","timestamp":1792659439870,"version":"4.5.0"},"reference-count":21,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The fluid content of Rathke cleft cysts (RCCs) displays variable appearances on magnetic resonance (MR) images and can appear indistinguishable from other intrasellar or suprasellar cystic lesions. Intracystic nodules associated with individual RCCs have been noted, but to date their significance has not been fully explored.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> The authors retrospectively reviewed MR imaging studies obtained in patients harboring intrasellar or suprasellar lesions that were consistent with RCCs to identify the presence and imaging characteristics of intracystic nodules.<\/jats:p>\n<jats:p content-type=\"fine-print\">An intracystic nodule was present in nine (45%) of 20 patients with an RCC. All intracystic nodules were clearly visible and displayed a characteristic low signal intensity on T<jats:sub>2<\/jats:sub>-weighted MR images. The nodule was only visualized on T<jats:sub>1<\/jats:sub>-weighted images in four cases, in which it exhibited a consistent high signal intensity similar to that of the cyst fluid. The nodules did not enhance following the intravenous administration of a contrast agent.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> Although it is difficult to differentiate RCCs from other sellar cystic lesions because of the variable signal intensities displayed on MR images, the intensity of the intracystic nodule seems consistent on T<jats:sub>1<\/jats:sub>- and T<jats:sub>2<\/jats:sub>-weighted images, and the nodule is always clearly visible on T<jats:sub>2<\/jats:sub>-weighted images. With a nonenhancing cystic lesion that does not cause significant symptoms in the patient, the identification of an intracystic nodule with a characteristic signal intensity will aid in the diagnosis of RCC and the selection of conservative management.<\/jats:p>","DOI":"10.3171\/jns.2005.103.5.0837","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:03:20Z","timestamp":1242237800000},"page":"837-840","source":"Crossref","is-referenced-by-count":59,"title":["Rathke cleft cyst intracystic nodule: a characteristic magnetic resonance imaging finding"],"prefix":"10.3171","volume":"103","author":[{"given":"Mandy J.","family":"Binning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren N.","family":"Gottfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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(Wien)","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/BF01407513","article-title":"Rathke's cleft cyst: computed tomographic scan and magnetic resonance imaging.","volume":"103","author":"Nakasu","year":"1990"},{"key":"b13","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1097\/00004728-199511000-00003","article-title":"Rathke cleft cyst: CT, MR, and pathology of 23 cases.","volume":"19","author":"Naylor","year":"1995"},{"key":"b14","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/BF00395617","article-title":"MR appearance of Rathke's cleft cysts.","volume":"30","author":"Nemoto","year":"1988"},{"key":"b15","series-title":"No Shinkei Geka","first-page":"125","article-title":"[Clinicopathological findings in symptomatic Rathke's cleft cyst: correlation between enhancement effects on MRI and histopathology of the cyst wall.]","volume":"24","author":"Niwa","year":"1996"},{"key":"b16","series-title":"Clin Neuropathol","first-page":"103","article-title":"Ciliated craniopharyngioma indicates histogenetic relationship to Rathke cleft epithelium.","volume":"16","author":"Oka","year":"1997"},{"key":"b17","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1227\/00006123-199202000-00004","article-title":"Radiologic characteristics and results of surgical management of Rathke's cysts in 43 patients.","volume":"30","author":"Ross","year":"1992"},{"key":"b18","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1007\/s007010050482","article-title":"MRI findings and clinical manifestations in Rathke's cleft cyst.","volume":"141","author":"Saeki","year":"1999"},{"key":"b19","series-title":"Anat Rec","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/ar.1091040402","article-title":"On the presence of cysts in the 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