{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:17:47Z","timestamp":1761823067959},"reference-count":51,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Surgical manipulation of the fifth cranial nerve during its intra- or extracranial course may lead to bradycardia or even asystole as well as arterial hypotension, a phenomenon described as the trigeminocardiac reflex (TCR). The authors studied the impact of this reflex on postoperative auditory function in patients undergoing vestibular schwannoma (VS) surgery.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>One hundred patients scheduled for VS surgery were studied prospectively for parameters influencing the postoperative auditory function. The evaluation included sex, age, pre- and postoperative auditory function, preoperative mean arterial blood pressure, preoperative medical diseases or medication (for example, antiarrhythmia drugs), tumor size and localization, and the intraoperative occurrence of the TCR.<\/jats:p>\n<jats:p>The TCR, which occurred in 11% of the patients, influenced the postoperative hearing function in the patients with Hannover Class T3 and T4 VSs.<\/jats:p>\n<jats:p>With an overall hearing preservation of 47%, 11.1% of the patients in the TCR group and 51.4% of those in the non-TCR group experienced preserved hearing function postoperatively. In cases involving larger tumors (Hannover Class T3 and T4), an intraoperative TCR was associated with a significantly worse postoperative hearing function during VS surgery (p = 0.005).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The hypotension following TCR is a negative prognostic factor for hearing preservation in patients undergoing VS surgery. Patients\u2019 knowledge of this can be increased pre- and postoperatively. Further study of this phenomenon will advance the understanding of the underlying mechanisms and may help to improve hearing preservation by controlling the occurrence of the TCR.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns.2006.104.3.369","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:30:53Z","timestamp":1201177853000},"page":"369-375","source":"Crossref","is-referenced-by-count":62,"title":["The impact of hypotension due to the trigeminocardiac reflex on auditory function in vestibular schwannoma surgery"],"prefix":"10.3171","volume":"104","author":[{"given":"Alireza","family":"Gharabaghi","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and Anesthesiology, International Neuroscience Institute, Hannover; Department of Neurosurgery, University Hospital, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Koerbel","sequence":"additional","affiliation":[{"name":"Departments 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