{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:11:19Z","timestamp":1770822679024,"version":"3.50.1"},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>\u2713Intraneural perineurioma is a true but rare neoplasm that originates from perineurial cells and mainly affects peripheral nerves. It must be distinguished from other hypertrophic neuropathies that are either inflammatory or demonstrate an onion-bulb formation that originates from Schwann cells. Complying with this strict definition, only three additional cases of cranium-related perineurioma have been identified: two lesions arose extracranially and involved cranial nerves, and one occurred intracranially but did not involve a nerve.<\/jats:p>\n<jats:p>The authors describe a 27-year-old woman who presented with left third cranial nerve palsy and was found to harbor a mass lesion in the superior orbital fissure and cavernous sinus. After subtotal resection had been performed, pathological studies confirmed the presence of perineurial tumor cells in a pseudo\u2013onion bulb formation. The cells stained positively for epithelial membrane antigen but not for S100 protein, clearly distinguishing the disease from one that originates in Schwann cells.<\/jats:p>","DOI":"10.3171\/jns.2006.104.5.824","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:32:55Z","timestamp":1201177975000},"page":"824-827","source":"Crossref","is-referenced-by-count":15,"title":["Intraneural perineurioma of the third cranial nerve: occurrence and identification"],"prefix":"10.3171","volume":"104","author":[{"given":"Rami","family":"Almefty","sequence":"first","affiliation":[{"name":"Semmes\u2013Murphey Clinic and Department of Neurosurgery, University of Tennessee Health Science Center; and Pathology Group of the MidSouth, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce L.","family":"Webber","sequence":"additional","affiliation":[{"name":"Semmes\u2013Murphey Clinic and Department of Neurosurgery, University of Tennessee Health Science Center; and Pathology Group of the MidSouth, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan I.","family":"Arnautovi\u0107","sequence":"additional","affiliation":[{"name":"Semmes\u2013Murphey Clinic and Department of Neurosurgery, University of Tennessee Health Science Center; and Pathology Group of the MidSouth, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1040824","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3171\/jns.1981.55.6.0987","article-title":"Isolated hypertrophic interstitial neuropathy of the trigeminal nerve associated with trigeminal neuralgia. 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