{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:19:59Z","timestamp":1790266799372,"version":"4.1.0"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>A retrospective analysis of a contemporary series of patients with pituitary apoplexy was performed to ascertain whether the histopathological features influence the clinical presentation or the outcome.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective analysis was performed in 59 patients treated for pituitary apoplexy at the University of Virginia Health System, Charlottesville, Virginia, or Groote Schuur Hospital, University of Cape Town, South Africa. The patients were divided into two groups according to the histological features of their disease: one group with infarction alone, comprising 22 patients; and the other with hemorrhagic infarction and\/or frank hemorrhage, comprising 37 patients. The presenting symptoms, clinical features, endocrinological status, and outcome were compared between the two groups.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The patients who presented with histological features of pituitary tumor infarction alone had less severe clinical features on presentation, a longer course prior to presentation, and a better outcome than those presenting with hemorrhagic infarction or frank hemorrhage. The endocrine replacement requirements were similar in both groups.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns.2006.104.6.931","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:35:22Z","timestamp":1201178122000},"page":"931-937","source":"Crossref","is-referenced-by-count":66,"title":["Pituitary apoplexy: do histological features influence the clinical presentation and outcome?"],"prefix":"10.3171","volume":"104","author":[{"given":"Patrick L.","family":"Semple","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Pathology, Groote Schuur Hospital, University of Cape Town, South Africa; and Departments of Pathology (Neuropathology) and Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques C.","family":"de Villiers","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Pathology, Groote Schuur Hospital, University of Cape Town, South Africa; and Departments of Pathology (Neuropathology) and Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Bowen","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Pathology, Groote Schuur Hospital, University of Cape Town, South Africa; and Departments of Pathology (Neuropathology) and Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Beatriz S.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Pathology, Groote Schuur Hospital, University of Cape Town, South Africa; and Departments of Pathology (Neuropathology) and Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Laws","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Pathology, Groote Schuur Hospital, University of Cape Town, South Africa; and Departments of Pathology (Neuropathology) and Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1040931","series-title":"Neurosurgery","first-page":"602","article-title":"A retrospective analysis of pituitary apoplexy","volume":"33","year":"1993"},{"key":"b2-1040931","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3171\/jns.1950.7.5.0421","article-title":"Acute degenerative changes in adenomas of the pituitary body\u2014with special reference to pituitary apoplexy","volume":"7","year":"1950"},{"key":"b3-1040931","series-title":"Neurosurgery","first-page":"363","article-title":"Pituitary apoplexy: a review","volume":"14","year":"1984"},{"key":"b4-1040931","series-title":"Neurol India","first-page":"490","article-title":"Hemorrhagic necrosis of pituitary adenomas","volume":"50","year":"2002"},{"key":"b5-1040931","series-title":"Adv Biosci","first-page":"461","article-title":"Non-haemorrhagic infarction of pituitary tumors presenting as pituitary apoplexy","volume":"69","year":"1988"},{"key":"b6-1040931","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3171\/jns.1983.58.3.0315","article-title":"Pituitary apoplexy treated by transsphenoidal surgery. 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