{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:29:28Z","timestamp":1770503368192,"version":"3.49.0"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>\u2713 Skull base chordomas containing a sarcomatous component are extremely rare. Here the authors report two new cases in which a recurrent tumor with a sarcomatous component appeared after the patient had undergone charged-particle radiotherapy. Histological examinations performed in Case 1 revealed some retention of epithelial features in the sarcomatous component, whereas no such regions were observed in Case 2. Both patients had rapidly deteriorating clinical courses and died within 6 months after diagnosis of the recurrent tumor. The authors discuss the significance of the histological subtypes of these tumors for long-term prognosis and their pathogenetic mechanisms in relation to radiotherapy. Although these sarcomatous transformations are rare in conventional chordomas, a careful histological examination and thorough follow-up imaging studies are crucial when treating patients with such lesions.<\/jats:p>","DOI":"10.3171\/jns.2006.105.1.136","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:37:07Z","timestamp":1201178227000},"page":"136-141","source":"Crossref","is-referenced-by-count":12,"title":["Sarcomatous transformation of clival chordoma after charged-particle radiotherapy"],"prefix":"10.3171","volume":"105","author":[{"given":"Takayuki","family":"Hara","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and Pathology, Faculty of Medicine, University of Tokyo; and Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Pathology, Faculty of Medicine, University of Tokyo; and Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Pathology, Faculty of Medicine, University of Tokyo; and Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Shibahara","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Pathology, Faculty of Medicine, University of Tokyo; and Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Ushiku","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Pathology, Faculty of Medicine, University of Tokyo; and Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Kirino","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Pathology, Faculty of Medicine, University of Tokyo; and Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1050136","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3171\/jns.1997.86.2.0182","article-title":"Skull base chordomas: a management challenge","volume":"86","year":"1997"},{"key":"b2-1050136","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3171\/jns.1993.78.4.0673","article-title":"The mandibular swing-transcervical approach to the skull base: anatomical study. 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