{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T20:54:22Z","timestamp":1786913662387,"version":"build-2736575974"},"reference-count":23,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,7]]},"abstract":"\nObject<\/jats:title>\nThe aim of this study was to estimate the accuracy of routine magnetic resonance (MR) imaging studies in the classification of brain tumors in terms of both cell type and grade of malignancy.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThe authors retrospectively assessed the correlation between neuroimaging classifications and histopathological diagnoses by using multicenter database records from 393 patients with brain tumors. An ontology was devised to establish diagnostic agreement. Each tumor category was compared with the corresponding histopathological diagnoses by dichotomization. Sensitivity, specificity, positive and negative predictive values (PPVs and NPVs, respectively), and the Wilson 95% confidence intervals (CI) for each were calculated.<\/jats:p>\nIn routine reporting of MR imaging examinations, tumor types and grades were classified with a high specificity (85.2\u2013100%); sensitivity varied, depending on the tumor type and grade, alone or in combination. The recognition of broad diagnostic categories (neuroepithelial or meningeal lesions) was highly sensitive, whereas when both detailed type and grade were considered, sensitivity diverged, being highest in low-grade meningioma (sensitivity 100%, 95% CI 96.2\u2013100.0%) and lowest in high-grade meningioma (sensitivity 0.0%, 95% CI 0.0\u201365.8%) and low-grade oligodendroglioma (sensitivity 15%, 95% CI 5.2\u201336.0%). In neuroepithelial tumors, sensitivity was inversely related to the precision in reporting of grade and cellular origin; \u201cglioma\u201d was a frequent neuroimaging classification associated with higher sensitivity in the corresponding category. The PPVs varied among categories, in general being greater than their prevalence in this dataset. The NPV was high in all categories (69.8\u2013100%).<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThe PPVs and NPVs provided in this study may be used as estimates of posttest probabilities of diagnostic accuracy using MR imaging. This study targets the need for noninvasively increasing sensitivity in categorizing most brain tumor types while retaining high specificity, especially in the differentiation of high- and low-grade glial tumor classes.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns.2006.105.1.6","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:37:07Z","timestamp":1201178227000},"page":"6-14","source":"Crossref","is-referenced-by-count":49,"title":["Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database"],"prefix":"10.3171","volume":"105","author":[{"given":"Margarida","family":"Juli\u00e0-Sap\u00e9","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionisio","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Maj\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0ngel","family":"Moreno-Torres","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Wesseling","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Acebes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Ar\u00fas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Science Faculty Unit, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain; Department of Computer Science and Information Technology, Universidad Sim\u00f3n Bol\u00edvar, Caracas, Venezuela; Institut de Diagn\u00f2stic per la Imatge, Hospital Duran i Reynals, Consorci Sanitari i Universitari de Bellvitge, L\u2019Hospitalet del Llobregat, Spain; Centre Diagn\u00f2stic Pedralbes\u2013Centre de Tractament amb Is\u00f2tops Radioactius, Esplugues del Llobregat..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1050006","series-title":"Statistics with Confidence. Confidence Intervals and Statistical Guidelines, ed 2","first-page":"105","article-title":"Diagnostic tests","year":"2001"},{"key":"b2-1050006","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"755","DOI":"10.3171\/jns.1997.86.5.0755","article-title":"Prediction of posterior fossa tumor type in children by means of magnetic resonance image properties, spectroscopy, and neural networks","volume":"86","year":"1997"},{"key":"b3-1050006","series-title":"International Network for Pattern Recognition of Tumours Using Magnetic Resonance"},{"key":"b4-1050006","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1080\/02688690209168363","article-title":"How well do radiologists diagnose intracerebral tumor histology on CT? Findings from a prospective multicentre study","volume":"16","year":"2002"},{"key":"b5-1050006","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1002\/1097-0142(19890515)63:10<2014::AID-CNCR2820631025>3.0.CO;2-L","article-title":"Cytologic composition of the untreated glioblastoma with implications for evaluation of needle biopsies","volume":"63","year":"1989"},{"key":"b6-1050006","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/(SICI)1097-0142(19970401)79:7<1381::AID-CNCR16>3.0.CO;2-W","article-title":"Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas","volume":"79","year":"1997"},{"key":"b7-1050006","series-title":"Neurosurgery","first-page":"48","article-title":"An analysis of the respective risks of hematoma formation in 361 consecutive morphological and functional stereotactic procedures","volume":"50","year":"2002"},{"key":"b8-1050006","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3171\/jns.2001.94.4.0545","article-title":"Comprehensive assessment of hemorrhage risks and outcomes after stereotactic brain biopsy","volume":"94","year":"2001"},{"key":"b9-1050006","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/jnen\/60.3.248","article-title":"Oligodendrogliomas: reproducibility and prognostic value of histologic diagnosis and grading","volume":"60","year":"2001"},{"key":"b10-1050006","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S0090-3019(97)00360-1","article-title":"The significance of lack of MR contrast enhancement of supratentorial brain tumors in adults: histopathological evaluation of a series","volume":"49","year":"1998"},{"key":"b11-1050006","series-title":"Radiologe","first-page":"808","article-title":"[Correlation of preoperative neuroradiological diagnosis with postoperative histological diagnosis in pathological intracranial processes.]","volume":"35","year":"1995"},{"key":"b12-1050006","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1002\/(SICI)1097-0142(19980501)82:9<1756::AID-CNCR23>3.0.CO;2-2","article-title":"The safety and efficacy of stereotactic biopsy for intracranial lesions","volume":"82","year":"1998"},{"key":"b13-1050006","series-title":"Welcome to the INTERPRET Project (IST-1999\u201310310) Funded by the European Commission","year":"1999"},{"key":"b14-1050006","series-title":"Guided Tour of the INTERPRET-Validated DB","year":"1999"},{"key":"b15-1050006","series-title":"Pathology and Genetics of Tumours of the Nervous System, ed 2","year":"2000"},{"key":"b16-1050006","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3171\/jns.1993.79.4.0533","article-title":"Unreliability of contemporary neurodiagnostic imaging in evaluating suspected adult supratentorial (low-grade) astrocytoma","volume":"79","year":"1993"},{"key":"b17-1050006","series-title":"AJNR Am J Neuroradiol","first-page":"1989","article-title":"Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging","volume":"24","year":"2003"},{"key":"b18-1050006","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00234-001-0760-0","article-title":"Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions","volume":"44","year":"2002"},{"key":"b19-1050006","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1080\/0268869021000007687","article-title":"The contribution of proton magnetic resonance spectroscopy (1HMRS) to clinical brain tumor diagnosis","volume":"16","year":"2002"},{"key":"b20-1050006","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1080\/0268869021000030267","article-title":"Neuropathological diagnostic accuracy","volume":"16","year":"2002"},{"key":"b21-1050006","series-title":"Diagnostic Neuroradiology","first-page":"529","article-title":"Astrocytomas and other glial neoplasms","year":"1994"},{"key":"b22-1050006","series-title":"Nat Med","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nm0396-323","article-title":"Accurate, noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy","volume":"2","year":"1996"},{"key":"b23-1050006","series-title":"Brief Bioinform","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1093\/bib\/1.4.398","article-title":"Ontology-based knowledge representation for bioinformatics","volume":"1","year":"2000"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/105\/1\/article-p6.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/105\/1\/article-p6.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/105\/1\/article-p6.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T09:48:18Z","timestamp":1709977698000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/105\/1\/article-p6.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":23,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.2006.105.1.6","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}