{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:04:36Z","timestamp":1762160676840},"reference-count":21,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,8]]},"abstract":"\nObject<\/jats:title>\nThe purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)\u2013induced hemiparkinsonian model.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThe authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA\u2013lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE).<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThe results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns.2006.105.2.284","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:37:17Z","timestamp":1201178237000},"page":"284-287","source":"Crossref","is-referenced-by-count":6,"title":["Effect of subthalamic nucleus lesions in a 6-hydroxydopamine\u2013induced rat parkinsonian model: behavioral and biochemical studies"],"prefix":"10.3171","volume":"105","author":[{"given":"Yong Sup","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Brain Korea 21 Project for Medical Science & Brain Research Institute, Yonsei University College of Medicine; and Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Insop","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brain Korea 21 Project for Medical Science & Brain Research Institute, Yonsei University College of Medicine; and Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bom Bee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brain Korea 21 Project for Medical Science & Brain Research Institute, Yonsei University College of Medicine; and Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Woo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brain Korea 21 Project for Medical Science & Brain Research Institute, Yonsei University College of Medicine; 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