{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:06:24Z","timestamp":1791893184657,"version":"4.3.4"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>When complicated by infection, craniotomy bone flaps are commonly removed, discarded, and delayed cranioplasty is performed. This treatment paradigm is costly, carries the risks associated with additional surgery, and may cause cosmetic deformities. The authors present their experience with an indwelling antibiotic irrigation system used for the sterilization and salvage of infected bone flaps as an alternative to their removal and replacement.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors retrospectively reviewed the medical records for 12 patients with bone flap infections following craniotomy who received treatment with the wash-in, wash-out indwelling antibiotic irrigation system. Infected flaps were removed and scrubbed with povidone\u2013iodine solution and soaked in 1.5% hydrogen peroxide while the wound was debrided. The bone flaps were returned to the skull and the irrigation system was installed. Antibiotic medication was infused through the system for a mean of 5 days. Intravenous antibiotic therapy was continued for 2 weeks and oral antibiotics for 3 months postoperatively. Wound checks were performed at clinic follow-up visits, and there was a mean follow-up period of 13 months. Eleven of the 12 patients who had undergone placement of the bone flap irrigation system experienced complete resolution of the infection. In five patients there was involvement of the nasal sinus cavities, and in four there was a history of radiation treatment. In the one patient whose infection recurred, there was both involvement of the nasal sinuses and a history of extensive radiation treatment.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Infected bone flaps can be salvaged, thus avoiding the cost, risk, and possible disfigurement associated with flap removal and delayed cranioplasty. Although prior radiation treatment and involvement of the nasal sinuses may interfere with wound healing and clearance of the infection, these factors should not preclude the use of irrigation with antibiotic agents for bone flap salvage.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns.2006.105.4.640","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:39:36Z","timestamp":1201178376000},"page":"640-644","source":"Crossref","is-referenced-by-count":62,"title":["Salvage of infected craniotomy bone flaps with the wash-in, wash-out indwelling antibiotic irrigation system"],"prefix":"10.3171","volume":"105","author":[{"given":"Kurtis I.","family":"Auguste","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco School of Medicine, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco School of Medicine, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1050640","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3171\/jns.1967.26.1part1.0041","article-title":"Wound infections complicating neurosurgical procedures","volume":"26","year":"1967"},{"key":"b2-1050640","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/BF01808684","article-title":"Infections in neurosurgery: a retrospective study of 1143 patients and 1517 operations","volume":"78","year":"1985"},{"key":"b3-1050640","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3171\/jns.1988.69.2.0216","article-title":"Results of a randomized trial of vancomycin prophylaxis in craniotomy","volume":"69","year":"1988"},{"key":"b4-1050640","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3171\/jns.2003.98.6.1203","article-title":"Preservation of bone flaps in patients with postcraniotomy infections","volume":"98","year":"2003"},{"key":"b5-1050640","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/neurosurgery\/23.CN_suppl_1.357","article-title":"Craniotomy infections","volume":"23","year":"1976"},{"key":"b6-1050640","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3171\/jns.1974.41.2.0265","article-title":"Suction-irrigation treatment of craniotomy infections. 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