{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T04:02:43Z","timestamp":1775966563947,"version":"3.50.1"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\u2713The aim of this study was to determine the effects of long-term continuous cerebrocortical electrical stimulation in the treatment of partial epilepsy. The authors review the case of a 44-year-old man with medically intractable postencephalitic localization-related epilepsy with ictal onset in the primary motor cortex. For 5 years he was treated using patterned subthreshold electrical stimulation of the ictal site. This therapy has successfully eliminated the jacksonian march of cortical excitability and secondary generalization and reduced seizure frequency and intensity with an immediate postictal return of motor function. Over time, the seizure frequency subsided by more than 90%, with the patient showing no adverse features resulting from focal stimulation.<\/jats:p>\n<jats:p>The results in this case support the hypothesis that effective and safe long-term modulation of focal epilepsy is possible with focal cerebrocortical electrical stimulation.<\/jats:p>","DOI":"10.3171\/jns.2006.105.6.894","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:41:37Z","timestamp":1201178497000},"page":"894-897","source":"Crossref","is-referenced-by-count":43,"title":["Long-term electrical stimulation\u2013induced inhibition of partial epilepsy"],"prefix":"10.3171","volume":"105","author":[{"given":"Kost","family":"Elisevich","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Jenrow","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Schuh","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brien","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1050894","series-title":"Proc Natl Acad Sci U S A","doi-asserted-by":"publisher","first-page":"10132","DOI":"10.1073\/pnas.132651299","article-title":"Dynamical model of long-term synaptic plasticity","volume":"99","year":"2002"},{"key":"b2-1050894","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/00006123-199908000-00030","article-title":"Cortical stimulation and epileptic seizure: a study of the potential risk in primates","volume":"45","year":"1999"},{"key":"b3-1050894","series-title":"Neurol Neurochir Pol","first-page":"605","article-title":"[Effect of cerebellar cortex electrostimulation on the frequency of epileptic seizures in severe forms of epilepsy.]","volume":"15","year":"1981"},{"issue":"3","key":"b4-1050894","series-title":"Neurosurg Focus","first-page":"E5","article-title":"Motor cortex stimulation","volume":"11","year":"2001"},{"key":"b5-1050894","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3171\/jns.1977.47.3.0366","article-title":"Tissue reactions to long-term electrical stimulation of the cerebellum in monkeys","volume":"47","year":"1977"},{"key":"b6-1050894","series-title":"Trans Am Neurol Assoc","first-page":"192","article-title":"The effect of chronic cerebellar stimulation upon epilepsy in man","volume":"98","year":"1973"},{"key":"b7-1050894","series-title":"Neurosurgery","first-page":"203","article-title":"Safety and efficacy of chronic stimulation","volume":"1","year":"1977"},{"key":"b8-1050894","series-title":"Appl Neurophysiol","first-page":"57","article-title":"Reduction of seizures in cerebral palsy and epileptic patients using chronic cerebellar stimulation","volume":"46","year":"1983"},{"key":"b9-1050894","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1001\/archneur.1975.00490490078008","article-title":"Chronic cerebellar stimulation in the monkey. 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