{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:36:00Z","timestamp":1771068960412,"version":"3.50.1"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Information on outcomes of Gamma Knife surgery (GKS) for patients harboring trigeminal schwannomas is limited because these tumors are rare. The authors evaluated tumor control and functional outcomes in patients who underwent GKS for trigeminal schwannomas to clarify the efficacy of this treatment.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Forty-two patients with trigeminal schwannomas but no evidence of neurofibromatosis Type 2 were treated with GKS at Komaki City Hospital between November 1991 and December 2003. Of these, 37 patients were assessed. The mean tumor volume in these patients was 10 cm<jats:sup>3<\/jats:sup>. The mean maximum radiation dose directed to the tumor was 27.9 Gy and the mean dose directed to the tumor margin was 14.2 Gy. The mean follow-up period was 54 months. In four patients (11%) there was complete tumor remission; in 20 (54%) there was partial tumor remission; in eight (22%) the disease remained stable; and in five (14%) the tumor enlarged or uncontrollable facial pain developed with radiation-induced edema requiring resection. The actuarial 5- and 10-year tumor control rates were both 84%. With respect to functional outcomes, 40% of patients noted an improvement in their symptoms, and one patient experienced new symptoms despite good tumor control.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Gamma Knife surgery was a safe and effective treatment for a select group of patients harboring trigeminal schwannomas. Large tumors that compress the brainstem and cause deviation of the fourth ventricle should first be removed surgically and any remnant should be treated by GKS.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns.2007.106.1.18","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:45:25Z","timestamp":1201178725000},"page":"18-23","source":"Crossref","is-referenced-by-count":53,"title":["Trigeminal schwannomas: results of Gamma Knife surgery in 37 cases"],"prefix":"10.3171","volume":"106","author":[{"given":"Toshinori","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouji","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1060018","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3171\/jns.2002.96.3.0453","article-title":"Trigeminal schwannomas: removal of dumbbell-shaped tumors through the expanded Meckel cave and outcomes of cranial nerve function","volume":"96","year":"2002"},{"key":"b2-1060018","series-title":"Surg Neurol","first-page":"497","article-title":"Neurinomas of the trigeminal nerve","volume":"4","year":"1975"},{"key":"b3-1060018","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00006123-199802000-00015","article-title":"The surgical management of trigeminal neuromas","volume":"42","year":"1998"},{"key":"b4-1060018","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1097\/00006123-199905000-00008","article-title":"Benign non-meningeal tumors of the cavernous sinus","volume":"44","year":"1999"},{"key":"b5-1060018","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1227\/01.NEU.0000053365.05795.03","article-title":"Trigeminal neuroma: analysis of surgical experience with 73 cases","volume":"52","year":"2003"},{"key":"b6-1060018","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1227\/01.NEU.0000166542.00512.84","article-title":"Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years","volume":"57","year":"2005"},{"key":"b7-1060018","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3171\/jns.2005.102.1.0010","article-title":"Long-term outcomes in patients with vestibular schwannomas treated using gamma knife surgery: 10-year follow-up","volume":"102","year":"2005"},{"key":"b8-1060018","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.surneu.2004.12.021","article-title":"Gamma knife radiosurgery for cavernous sinus metastases and invasion","volume":"64","year":"2005"},{"key":"b9-1060018","series-title":"Clin Neurosurg","first-page":"11","article-title":"The trigeminal neurinomas with some remarks on malignant invasion of the gasserian ganglion","volume":"1","year":"1953"},{"key":"b10-1060018","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0090-3019(01)00537-7","article-title":"Radiosurgery of cavernous hemangiomas in the cavernous sinus","volume":"56","year":"2001"},{"key":"b11-1060018","series-title":"Radiosurgery, Vol 2","first-page":"8","article-title":"Radiosurgery of trigeminal neurinoma","year":"1997"},{"key":"b12-1060018","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1056\/NEJM199811123392003","article-title":"Long-term outcomes after radiosurgery for acoustic neuromas","volume":"339","year":"1998"},{"key":"b13-1060018","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1227\/01.NEU.0000083027.44876.B2","article-title":"Long-term results after radiosurgery for benign intracranial tumors","volume":"53","year":"2003"},{"key":"b14-1060018","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/BF01412304","article-title":"Trigeminal neurinomas. 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