{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:20:17Z","timestamp":1758475217877},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Cerebral aneurysm is a major cause of subarachnoid hemorrhage, but the mechanisms of its development remain unclear. Mechanical stretch has been reported to induce vascular smooth-muscle cell apoptosis via endothelin B receptors (ETBRs). The objectives of this study were to clarify the expression and localization of ETBR in cerebral aneurysms and to examine the effect of ETBR blockage on the development of experimental cerebral aneurysms.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Seventy-two rats underwent a cerebral aneurysm induction procedure and were divided into four groups according to the duration of postoperative study periods. Expression of ETBR was confirmed by reverse transcription\u2013polymerase chain reaction and immunohistochemical analysis. The authors also studied the effect of K-8794, an oral selective antagonist of ETBR, to see whether it would influence the formation of cerebral aneurysms.<\/jats:p>\n<jats:p>Two weeks after the aneurysm induction procedure, ETBR was rarely detected in anterior cerebral artery\u2013olfactory artery bifurcations, but it was weakly expressed in experimental cerebral aneurysms at 1 month after the procedure, and markedly expressed at 3 months. The administration of K-8794 for 1 month after the procedure significantly reduced the number of advanced aneurysms and the number of apoptotic smooth-muscle cells.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>These results suggest that ETBR might play a significant role in the progression of cerebral aneurysms and have the potential to improve prevention and treatment of cerebral aneurysms.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns.2007.106.2.330","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:44:23Z","timestamp":1201178663000},"page":"330-336","source":"Crossref","is-referenced-by-count":14,"title":["Cerebral aneurysm progression suppressed by blockage of endothelin B receptor"],"prefix":"10.3171","volume":"106","author":[{"given":"Nobutake","family":"Sadamasa","sequence":"first","affiliation":[{"name":"1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nozaki","sequence":"additional","affiliation":[{"name":"1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Takagi","sequence":"additional","affiliation":[{"name":"1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Kawanabe","sequence":"additional","affiliation":[{"name":"1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsune","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"2Department of Neurosurgery, Kitano Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1060330","series-title":"Cell Death Differ","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/sj.cdd.4400936","article-title":"Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent","volume":"9","year":"2002"},{"key":"b2-1060330","series-title":"FASEB J","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1096\/fasebj.14.7.991","article-title":"Stretch-induced endothelin B receptor-mediated apoptosis in vascular smooth muscle cells","volume":"14","year":"2000"},{"key":"b3-1060330","series-title":"Br J Pharmacol","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/sj.bjp.0706193","article-title":"Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1","volume":"145","year":"2005"},{"key":"b4-1060330","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1161\/01.CIR.101.21.2532","article-title":"Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase","volume":"101","year":"2000"},{"key":"b5-1060330","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1161\/01.STR.26.9.1659","article-title":"Immunohistochemical alterations of fibronectin during the formation and proliferative repair of experimental cerebral aneurysms in rats","volume":"26","year":"1995"},{"key":"b6-1060330","series-title":"Surg Neurol","first-page":"3","article-title":"Experimentally induced cerebral aneurysms in rats","volume":"10","year":"1978"},{"key":"b7-1060330","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3171\/jns.1987.67.6.0903","article-title":"Experimental induction of cerebral aneurysms in monkeys","volume":"67","year":"1987"},{"key":"b8-1060330","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1161\/01.STR.30.7.1396","article-title":"Structural fragility and inflammatory response of ruptured cerebral aneurysms. 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