{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T06:41:01Z","timestamp":1794638461730,"version":"4.9.1"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Dysembryoplastic neuroepithelial tumors (DNTs) are commonly associated with medically resistant epilepsy that usually starts in childhood. Presurgical workup and surgical strategies remain controversial. The authors present a study of long-term seizure outcome after noninvasive presurgical investigations and different surgical strategies were used in a series of pediatric patients.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Twenty-four children who underwent operations at a single center between 1986 and 2006 were eligible for this retrospective study. The authors reviewed medical records including sex, age at seizure onset, age at surgery, seizure type and pharmacoresistance, lesion location, extent and complications of resection, histopathological findings, prescription of seizure and antiepileptic drugs, outcome, and tumor recurrence.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>At the last follow-up examination (range 1\u201316 years after initial treatment, mean 6.7 years) 20 children (83.3%) were seizure free. The authors did not find the rundown phenomenon in any of the patients. Complete antiepileptic drug withdrawal was achieved in 12 children (50%). In 4 of 15 children with temporal DNTs, the lesionectomy alone failed to control seizures. These results could be explained by the wider epileptogenic zone. The only significant predictor for favorable seizure outcome was an absence of preoperative generalized seizures.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In children with extratemporal DNTs the results suggest that complete lesionectomy alone without invasive presurgical investigations are effective for long-term seizure control. For children with temporal DNTs not invading the amygdalohippocampal complex, extensive presurgical evaluations seem indicated. The absence of preoperative generalized seizures was associated with a better seizure outcome.<\/jats:p><\/jats:sec>","DOI":"10.3171\/ped\/2008\/1\/3\/206","type":"journal-article","created":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T18:54:07Z","timestamp":1204311247000},"page":"206-210","source":"Crossref","is-referenced-by-count":66,"title":["Surgical strategies and seizure control in pediatric patients with dysembryoplastic neuroepithelial tumors: a single-institution experience"],"prefix":"10.3171","volume":"1","author":[{"given":"Krasimir","family":"Minkin","sequence":"first","affiliation":[{"name":"Departments of Pediatric Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Klein","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Mancini","sequence":"additional","affiliation":[{"name":"Pediatric Neurology, University Hospital La Timone, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Lena","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0010206","series-title":"Epilepsy Res","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0920-1211(00)00208-4","article-title":"Glioneuronal tumors and medically intractable epilepsy: a clinical study with long-term follow-up of seizure outcome after surgery","volume":"43","author":"Aronica","year":"2001"},{"key":"b2-0010206","series-title":"Epilepsy Res","first-page":"566","article-title":"Multivariable prediction of seizure outcome one year after resective epilepsy surgery: development of a model with independent validation","volume":"35","author":"Berg","year":"1998"},{"key":"b3-0010206","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1007\/s00381-006-0145-0","article-title":"Pre-surgical evaluation and surgical treatment in children with extratemporal epilepsy","volume":"22","author":"Centeno","year":"2006"},{"key":"b4-0010206","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3171\/jns.2006.104.1.62","article-title":"Long-term outcome following surgery for dysembryoplastic neuroepithelial tumor","volume":"104","author":"Chan","year":"2006"},{"key":"b5-0010206","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1007\/s00381-006-0127-2","article-title":"Stereo-EEG in children","volume":"22","author":"Cossu","year":"2006"},{"key":"b6-0010206","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1227\/00006123-198811000-00002","article-title":"Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. 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