{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:53:13Z","timestamp":1780357993178,"version":"3.54.1"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>\u2713The authors present a case of scalp and facial edema following craniofacial reconstruction for metopic craniosynostosis in which recombinant human bone morphogenetic protein\u20132 (rhBMP-2) was used to treat cranial defects related to the frontoorbital reconstruction. The extent of swelling, the onset, and duration were unusual for such cases and suggested a possible role of rhBMP-2 in inducing a local inflammatory response. The edema rapidly resolved after the patient underwent surgery to remove the rhBMP-2 implants.<\/jats:p>","DOI":"10.3171\/ped\/2008\/1\/3\/255","type":"journal-article","created":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T18:54:07Z","timestamp":1204311247000},"page":"255-257","source":"Crossref","is-referenced-by-count":46,"title":["Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein\u20132 in cranial reconstruction for craniosynostosis"],"prefix":"10.3171","volume":"1","author":[{"given":"M. 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