{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:04:25Z","timestamp":1792285465909,"version":"4.4.0"},"reference-count":64,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4]]},"abstract":"\n Object.<\/jats:italic>\n Slow-growing, low-grade temporal lobe tumors are one of the most common causes of epilepsy in children. Although there are numerous consistent features in this patient group, consensus about the management and surgical approach is lacking. In this study the authors review the clinical, pathological, and radiological features as well as outcome data obtained in 29 pediatric patients with temporal lobe tumor\u2014related epilepsy and discuss the surgical treatment strategies.\n <\/jats:p>\n \n Methods.<\/jats:italic>\n In patients who presented with intractable seizures secondary to mass lesions and underwent comprehensive epilepsy workup, the tumor was resected and the diagnosis confirmed by pathological examination. A minimum follow-up period of 16 months was required. Medical records were reviewed for details of seizure type and duration, electrophysiological data, imaging studies, operative notes, pathological examination reports, and follow-up data. The surgical approach was as follows. The lesionectomy with\/without cortical resection was performed in all cases of lateral temporal tumors. Lesionectomy was performed with\/without cortical resection in cases of basal temporal tumors if the mesial structures were radiologically normal. Mesial temporal tumors were excised, as were the remaining mesial temporal structures in the nondominant hemisphere; however, if the tumor was in the dominant hemisphere, lesionectomy was performed only if the remaining mesial structures were radiologically normal.\n <\/jats:p>\n Twenty-nine patients between 2 and 18 years of age were identified. Most tumors were located in the mesial temporal lobe. All patients underwent resection of the tumor with or without mesial and cortical structures. The most common pathological entity was dysembryoplastic neuroepithelial tumor. Sixty-nine percent of the patients remained seizure free (Engel Class I) and 14% experienced significant improvement (Engel Class II) after surgery. Outcome was better in the patients who underwent gross-total tumor resection.<\/jats:p>\n \n Conclusions.<\/jats:italic>\n Mesially located low-grade neoplasms were the most frequently observed mass lesions in children with temporal tumor\u2014related epilepsy in this series. Resection of the tumor with or without amygdalohippocampectomy provides a high rate of seizure-free outcome. It is the author's opinion that temporal lobe tumors should be managed based on the subgroups defined by their anatomical locations. If the tumor is located in or in proximity to eloquent cortex, we recommend functional magnetic resonance imaging and invasive monitoring techniques to map the eloquent cortex and epileptogenic zone, thereby tailoring the resection.\n <\/jats:p>","DOI":"10.3171\/ped.2005.102.3.0280","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T06:00:52Z","timestamp":1282888852000},"page":"280-287","source":"Crossref","is-referenced-by-count":17,"title":["Surgical management of temporal lobe tumor\u2014related epilepsy in children"],"prefix":"10.3171","volume":"102","author":[{"given":"Oguz","family":"\u00c7ataltepe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fczide","family":"Turanli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Yalnizoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Top\u00e7u","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nejat","family":"Akalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1528-1157.1991.tb05242.x","article-title":"Intractable epilepsy and structural lesions of the brain: mapping, resection strategies, and seizure outcome.","volume":"32","author":"Awad","year":"1991"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3171\/jns.1993.79.1.0062","article-title":"Low-grade gliomas associated with intractable epilepsy: seizure outcome utilizing electrocorticography during tumor resection.","volume":"79","author":"Berger","year":"1993"},{"key":"b3","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1002\/ana.410120606","article-title":"Childhood brain tumors presenting as chronic uncontrolled focal seizure disorders.","volume":"12","author":"Blume","year":"1982"},{"key":"b4","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1528-1157.1991.tb04679.x","article-title":"Intracranial, intraaxial, space-occupying lesions in patients with intractable partial seizures: an anatomoclinical, neurophysiological, and surgical correlation.","volume":"32","author":"Boon","year":"1991"},{"key":"b5","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1111\/j.1528-1157.1994.tb01778.x","article-title":"Low-grade glial neoplasms and intractable partial epilepsy: efficacy of surgical treatment.","volume":"35","author":"Britton","year":"1994"},{"key":"b6","series-title":"Magn Reson Imaging","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/0730-725X(95)02026-P","article-title":"MR characteristics of neoplasms and vascular malformations associated with epilepsy.","volume":"13","author":"Bronen","year":"1995"},{"key":"b7","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1111\/j.1528-1157.1990.tb05858.x","article-title":"Epilepsy and brain tumors: implications for treatment.","volume":"31","author":"Cascino","year":"1990"},{"key":"b8","series-title":"Epilepsy Res","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0920-1211(93)90022-Y","article-title":"Operative strategy in patients with MRI-identified dual pathology and temporal lobe epilepsy.","volume":"14","author":"Cascino","year":"1993"},{"key":"b9","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1227\/00006123-198712000-00003","article-title":"Surgical management of children with temporal lobe epilepsy and mass lesions.","volume":"21","author":"Drake","year":"1987"},{"key":"b10","series-title":"Surgical Treatment of Epilepsies.","first-page":"553","year":"1987"},{"key":"b11","series-title":"Surgical Treatment of the Epilepsies","first-page":"501","article-title":"Lesional surgery","author":"Fried","year":"1993"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3171\/jns.1992.76.5.0735","article-title":"Hippocampal pathology in patients with intractable seizures and temporal lobe mass.","volume":"76","author":"Fried","year":"1992"},{"key":"b13","series-title":"Neurosurgery","first-page":"815","article-title":"Limbic and neocortical gliomas associated with intractable seizures: a distinct clinicopathological group.","volume":"34","author":"Fried","year":"1994"},{"key":"b14","series-title":"Clin Neurosurg","first-page":"15","article-title":"Experience with gliomas in patients presenting with chronic seizure disorder.","volume":"33","author":"Goldring","year":"1986"},{"key":"b15","series-title":"Brain","first-page":"364","article-title":"Localised convulsions from tumour of the brain.","volume":"5","author":"Hughlings-Jackson","year":"1882\/1883"},{"key":"b16","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1159\/000028946","article-title":"Surgical treatment of temporal tumors associated with epilepsy in children.","volume":"32","author":"Ianelli","year":"2000"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3171\/jns.1995.83.2.0231","article-title":"Lesionectomy versus electrophysiologically guided resection for temporal lobe tumors manifesting with complex partial seizures.","volume":"83","author":"Jooma","year":"1995"},{"key":"b18","series-title":"J Child Neurol","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/088307389901400102","article-title":"Surgical management of pediatric tumor-associated epilepsy.","volume":"14","author":"Khajavi","year":"1999"},{"key":"b19","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1007\/BF00300720","article-title":"Intractable seizures associated with brain tumor in childhood: lesionectomy and seizure outcome.","volume":"11","author":"Kim","year":"1995"},{"key":"b20","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3171\/jns.1993.78.1.0019","article-title":"Control of temporal lobe epilepsy following en bloc resection of low-grade tumors.","volume":"78","author":"Kirkpatrick","year":"1993"},{"key":"b21","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3171\/jns.1984.61.4.0665","article-title":"Neurosurgical management of low-grade astrocytoma of the cerebral hemispheres.","volume":"61","author":"Laws","year":"1984"},{"key":"b22","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1046\/j.1528-1157.2003.56102.x","article-title":"The spectrum of long-term epilepsy\u2014associated tumors: long-term seizure and tumor outcome and neurosurgical aspects.","volume":"44","author":"Luyken","year":"2003"},{"key":"b23","series-title":"Epilepsy Res","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0920-1211(95)00014-2","article-title":"The pathophysiologic relationships between lesion pathology, intracranial ictal EEG onsets, and hippocampal neuron loss in temporal loe epilepsy.","volume":"21","author":"Mathern","year":"1995"},{"key":"b24","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/j.1528-1157.1993.tb02131.x","article-title":"Chronic intractable epilepsy as the only symptom of primary brain tumor.","volume":"34","author":"Morris","year":"1993"},{"key":"b25","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3171\/jns.1994.80.6.0998","article-title":"Seizure control following tumor surgery for childhood cortical low-grade gliomas.","volume":"80","author":"Packer","year":"1994"},{"key":"b26","series-title":"Neurosurgery","first-page":"627","article-title":"Low-grade astrocytomas may arise from different astrocyte lineages.","volume":"33","author":"Piepmeier","year":"1993"},{"key":"b27","series-title":"Adv Neurol","first-page":"227","article-title":"Surgery of epilepsy associated with brain tumors.","volume":"8","author":"Rasmussen","year":"1975"},{"key":"b28","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/neurosurgery\/7.CN_suppl_1.138","article-title":"Epilepsy and brain tumor.","volume":"7","author":"Rasmussen","year":"1961"},{"key":"b29","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1212\/WNL.34.4.432","article-title":"Intracerebral masses in patients with intractable partial epilepsy.","volume":"34","author":"Spencer","year":"1984"},{"key":"b30","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/00005072-199309000-00008","article-title":"Surgical pathology of temporal lobe epilepsy. Experience with 216 cases.","volume":"52","author":"Wolf","year":"1993"},{"key":"b31","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1212\/01.WNL.0000079374.78589.1B","article-title":"Temporal lobe tumoral epilepsy: characteristics and predictors of surgical outcome.","volume":"61","author":"Zaatreh","year":"2003"},{"key":"b32","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/00006123-199708000-00008","article-title":"Surgical treatment of neoplasms associated with medically intractable epilepsy.","volume":"41","author":"Zentner","year":"1997"},{"key":"b1","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1528-1157.1991.tb05242.x","article-title":"Intractable epilepsy and structural lesions of the brain: mapping, resection strategies, and seizure outcome.","volume":"32","author":"Awad","year":"1991"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3171\/jns.1993.79.1.0062","article-title":"Low-grade gliomas associated with intractable epilepsy: seizure outcome utilizing electrocorticography during tumor resection.","volume":"79","author":"Berger","year":"1993"},{"key":"b3","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1002\/ana.410120606","article-title":"Childhood brain tumors presenting as chronic uncontrolled focal seizure disorders.","volume":"12","author":"Blume","year":"1982"},{"key":"b4","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1528-1157.1991.tb04679.x","article-title":"Intracranial, intraaxial, space-occupying lesions in patients with intractable partial seizures: an anatomoclinical, neurophysiological, and surgical correlation.","volume":"32","author":"Boon","year":"1991"},{"key":"b5","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1111\/j.1528-1157.1994.tb01778.x","article-title":"Low-grade glial neoplasms and intractable partial epilepsy: efficacy of surgical treatment.","volume":"35","author":"Britton","year":"1994"},{"key":"b6","series-title":"Magn Reson Imaging","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/0730-725X(95)02026-P","article-title":"MR characteristics of neoplasms and vascular malformations associated with epilepsy.","volume":"13","author":"Bronen","year":"1995"},{"key":"b7","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1111\/j.1528-1157.1990.tb05858.x","article-title":"Epilepsy and brain tumors: implications for treatment.","volume":"31","author":"Cascino","year":"1990"},{"key":"b8","series-title":"Epilepsy Res","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0920-1211(93)90022-Y","article-title":"Operative strategy in patients with MRI-identified dual pathology and temporal lobe epilepsy.","volume":"14","author":"Cascino","year":"1993"},{"key":"b9","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1227\/00006123-198712000-00003","article-title":"Surgical management of children with temporal lobe epilepsy and mass lesions.","volume":"21","author":"Drake","year":"1987"},{"key":"b10","series-title":"Surgical Treatment of Epilepsies.","first-page":"553","year":"1987"},{"key":"b11","series-title":"Surgical Treatment of the Epilepsies","first-page":"501","article-title":"Lesional surgery","author":"Fried","year":"1993"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3171\/jns.1992.76.5.0735","article-title":"Hippocampal pathology in patients with intractable seizures and temporal lobe mass.","volume":"76","author":"Fried","year":"1992"},{"key":"b13","series-title":"Neurosurgery","first-page":"815","article-title":"Limbic and neocortical gliomas associated with intractable seizures: a distinct clinicopathological group.","volume":"34","author":"Fried","year":"1994"},{"key":"b14","series-title":"Clin Neurosurg","first-page":"15","article-title":"Experience with gliomas in patients presenting with chronic seizure disorder.","volume":"33","author":"Goldring","year":"1986"},{"key":"b15","series-title":"Brain","first-page":"364","article-title":"Localised convulsions from tumour of the brain.","volume":"5","author":"Hughlings-Jackson","year":"1882\/1883"},{"key":"b16","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1159\/000028946","article-title":"Surgical treatment of temporal tumors associated with epilepsy in children.","volume":"32","author":"Ianelli","year":"2000"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3171\/jns.1995.83.2.0231","article-title":"Lesionectomy versus electrophysiologically guided resection for temporal lobe tumors manifesting with complex partial seizures.","volume":"83","author":"Jooma","year":"1995"},{"key":"b18","series-title":"J Child Neurol","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/088307389901400102","article-title":"Surgical management of pediatric tumor-associated epilepsy.","volume":"14","author":"Khajavi","year":"1999"},{"key":"b19","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1007\/BF00300720","article-title":"Intractable seizures associated with brain tumor in childhood: lesionectomy and seizure outcome.","volume":"11","author":"Kim","year":"1995"},{"key":"b20","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3171\/jns.1993.78.1.0019","article-title":"Control of temporal lobe epilepsy following en bloc resection of low-grade tumors.","volume":"78","author":"Kirkpatrick","year":"1993"},{"key":"b21","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3171\/jns.1984.61.4.0665","article-title":"Neurosurgical management of low-grade astrocytoma of the cerebral hemispheres.","volume":"61","author":"Laws","year":"1984"},{"key":"b22","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1046\/j.1528-1157.2003.56102.x","article-title":"The spectrum of long-term epilepsy\u2014associated tumors: long-term seizure and tumor outcome and neurosurgical aspects.","volume":"44","author":"Luyken","year":"2003"},{"key":"b23","series-title":"Epilepsy Res","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0920-1211(95)00014-2","article-title":"The pathophysiologic relationships between lesion pathology, intracranial ictal EEG onsets, and hippocampal neuron loss in temporal loe epilepsy.","volume":"21","author":"Mathern","year":"1995"},{"key":"b24","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/j.1528-1157.1993.tb02131.x","article-title":"Chronic intractable epilepsy as the only symptom of primary brain tumor.","volume":"34","author":"Morris","year":"1993"},{"key":"b25","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3171\/jns.1994.80.6.0998","article-title":"Seizure control following tumor surgery for childhood cortical low-grade gliomas.","volume":"80","author":"Packer","year":"1994"},{"key":"b26","series-title":"Neurosurgery","first-page":"627","article-title":"Low-grade astrocytomas may arise from different astrocyte lineages.","volume":"33","author":"Piepmeier","year":"1993"},{"key":"b27","series-title":"Adv Neurol","first-page":"227","article-title":"Surgery of epilepsy associated with brain tumors.","volume":"8","author":"Rasmussen","year":"1975"},{"key":"b28","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/neurosurgery\/7.CN_suppl_1.138","article-title":"Epilepsy and brain tumor.","volume":"7","author":"Rasmussen","year":"1961"},{"key":"b29","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1212\/WNL.34.4.432","article-title":"Intracerebral masses in patients with intractable partial epilepsy.","volume":"34","author":"Spencer","year":"1984"},{"key":"b30","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/00005072-199309000-00008","article-title":"Surgical pathology of temporal lobe epilepsy. Experience with 216 cases.","volume":"52","author":"Wolf","year":"1993"},{"key":"b31","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1212\/01.WNL.0000079374.78589.1B","article-title":"Temporal lobe tumoral epilepsy: characteristics and predictors of surgical outcome.","volume":"61","author":"Zaatreh","year":"2003"},{"key":"b32","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/00006123-199708000-00008","article-title":"Surgical treatment of neoplasms associated with medically intractable epilepsy.","volume":"41","author":"Zentner","year":"1997"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/102\/3\/article-p280.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/102\/3\/article-p280.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/102\/3\/article-p280.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:19:08Z","timestamp":1782209948000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/102\/3\/article-p280.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":64,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/ped.2005.102.3.0280","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}