{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:49:00Z","timestamp":1782211740998,"version":"3.54.5"},"reference-count":74,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4]]},"abstract":"\n Object.<\/jats:italic>\n The JC virus is a human neurotropic polyomavirus that causes progressive multifocal leukoencephalopathy and is closely related to simian virus 40. Several recent reports have indicated a possible association between the JC virus and the development of various human brain tumors. The authors examined the presence of JC virus DNA sequences in primary brain tumors in pediatric patients to evaluate the hypothesis that particular brain tumors can arise in the pediatric population as a consequence of infection with the JC virus.\n <\/jats:p>\n \n Methods.<\/jats:italic>\n Genomic DNA sequences were isolated from 62 brain tumors (32 medulloblastomas, 18 ependymomas, five choroid plexus papillomas, and seven pilocytic astrocytomas) and analyzed for the presence of JC virus DNA by Southern blot hybridization and direct sequencing. The JC virus DNA sequence was detected in five ependymomas and one choroid plexus papilloma. Immunohistochemical studies revealed nuclear expression of the large T-antigen in a choroid plexus papilloma. None of the medulloblastomas or pilocytic astrocytomas contained JC virus DNA.\n <\/jats:p>\n \n Conclusions.<\/jats:italic>\n The results of this study provide molecular evidence of the association between JC virus and the development of certain ependymomas and choroid plexus papillomas.\n <\/jats:p>","DOI":"10.3171\/ped.2005.102.3.0294","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T06:00:52Z","timestamp":1282888852000},"page":"294-298","source":"Crossref","is-referenced-by-count":3,"title":["Detection of JC virus DNA sequences in brain tumors in pediatric patients"],"prefix":"10.3171","volume":"102","author":[{"given":"Hiroaki","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Mineta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tabuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1056\/NEJM199204093261504","article-title":"DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood.","volume":"326","author":"Bergsagel","year":"1992"},{"key":"b2","series-title":"Tumors of the Pediatric Central Nervous System.","first-page":"14","article-title":"Epidemiology of Brain Tumors","author":"Bestak","year":"2001"},{"key":"b3","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1007\/s003810050467","article-title":"Epidemiologic impact of children with brain tumors.","volume":"15","author":"Bleyer","year":"1999"},{"key":"b4","series-title":"J Neurovirol","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/13550280390194055","article-title":"Brain tumors and polyomaviruses.","volume":"9","author":"Croul","year":"2003"},{"key":"b5","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1212\/WNL.58.6.895","article-title":"Expression of JC virus T-antigen in a patient with MS and glioblastoma multiforme.","volume":"58","author":"Del Valle","year":"2002"},{"key":"b6","series-title":"Clin Cancer Res","first-page":"3332","article-title":"Detection of JC polyomavirus DNA sequences and cellular localization of T-antigen and agnoprotein in oligodendrogliomas.","volume":"8","author":"Del Valle","year":"2002"},{"key":"b7","series-title":"Cancer Res","first-page":"4287","article-title":"Detection of JC virus DNA sequences and expression of the viral regulatory protein T-antigen in tumors of the central nervous system.","volume":"61","author":"Del Valle","year":"2001"},{"key":"b8","series-title":"J Virol","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1128\/jvi.64.3.1353-1356.1990","article-title":"Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.","volume":"64","author":"Dyson","year":"1990"},{"key":"b9","series-title":"Cancer Res","first-page":"7093","article-title":"Association of human polyomavirus JC VIRUS with colon cancer: evidence for interaction of viral T-antigen and \u03b2-catenin.","volume":"62","author":"Enam","year":"2002"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3171\/jns.1984.61.4.0657","article-title":"Medulloblastoma in childhood: an epidemiological study.","volume":"61","author":"Farwell","year":"1984"},{"key":"b11","series-title":"Science","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1126\/science.167.3914.59","article-title":"Simian virus 40 in polio vaccine: follow-up of new born recipients.","volume":"167","author":"Fraumeni","year":"1970"},{"key":"b12","series-title":"J 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infection with the JC human polyoma virus and has implications for oncopenesis.","volume":"93","author":"Neel","year":"1996"},{"key":"b31","series-title":"Lancet","first-page":"1257","article-title":"Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy.","volume":"1","author":"Padgett","year":"1971"},{"key":"b32","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"7352","DOI":"10.1073\/pnas.93.14.7352","article-title":"Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma.","volume":"93","author":"Rencic","year":"1996"},{"key":"b33","series-title":"J Virol","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1128\/JVI.75.3.1476-1486.2001","article-title":"Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial 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antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.","volume":"64","author":"Dyson","year":"1990"},{"key":"b9","series-title":"Cancer Res","first-page":"7093","article-title":"Association of human polyomavirus JC VIRUS with colon cancer: evidence for interaction of viral T-antigen and \u03b2-catenin.","volume":"62","author":"Enam","year":"2002"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3171\/jns.1984.61.4.0657","article-title":"Medulloblastoma in childhood: an epidemiological study.","volume":"61","author":"Farwell","year":"1984"},{"key":"b11","series-title":"Science","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1126\/science.167.3914.59","article-title":"Simian virus 40 in polio vaccine: follow-up of new born recipients.","volume":"167","author":"Fraumeni","year":"1970"},{"key":"b12","series-title":"J Virol","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1128\/jvi.51.2.458-469.1984","article-title":"Human polyomavirus JC virus genome.","volume":"51","author":"Frisque","year":"1984"},{"key":"b13","series-title":"Neurosurgery","first-page":"687","article-title":"Virus-, radiation-, and chemical-induced brain tumors","volume":"1","author":"Fuchs","year":"1996"},{"key":"b14","series-title":"J Neurovirol","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3109\/13550289809114517","article-title":"Tumor pathogenesis of human neurotropic JC virus in the CNS.","volume":"4","author":"Gallia","year":"1998"},{"key":"b15","series-title":"Oncogene","doi-asserted-by":"publisher","first-page":"4864","DOI":"10.1038\/sj.onc.1204670","article-title":"Involvement of Wnt signaling pathway in murine medulloblastoma induced by human neurotropic JC virus.","volume":"20","author":"Gan","year":"2001"},{"key":"b16","series-title":"Neuropathology","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1046\/j.1440-1789.2001.00384.x","article-title":"JC virus large T protein transforms rodent cells but is not involved in human medulloblastoma.","volume":"21","author":"Hayashi","year":"2001"},{"key":"b17","series-title":"Int J Epidemiol","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/ije\/2.3.229","article-title":"Immunization during pregnancy against poliomyelitis and influenza in relation to childhood malignancy.","volume":"2","author":"Heinonen","year":"1973"},{"key":"b18","series-title":"Brain Pathol","first-page":"33","article-title":"Identification in human brain tumors of DNA sequences specific for SV40 large T antigen.","volume":"9","author":"Huang","year":"1999"},{"key":"b19","series-title":"Dis Markers","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1155\/2001\/423875","article-title":"Human 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Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"11519","DOI":"10.1073\/pnas.96.20.11519","article-title":"Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas.","volume":"96","author":"Krynska","year":"1999"},{"key":"b25","series-title":"J Cell Biochem","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/(SICI)1097-4644(19971101)67:2<223::AID-JCB7>3.0.CO;2-Z","article-title":"Role of cell cycle regulators in tumor formation in transgenic mice expressing the human neurotropic virus, JC VIRUS, early protein.","volume":"67","author":"Krynska","year":"1997"},{"key":"b26","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"7484","DOI":"10.1073\/pnas.96.13.7484","article-title":"JC virus DNA is present in the mucosa of the human colon and in colorectal 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infection with the JC human polyoma virus and has implications for oncopenesis.","volume":"93","author":"Neel","year":"1996"},{"key":"b31","series-title":"Lancet","first-page":"1257","article-title":"Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy.","volume":"1","author":"Padgett","year":"1971"},{"key":"b32","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"7352","DOI":"10.1073\/pnas.93.14.7352","article-title":"Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma.","volume":"93","author":"Rencic","year":"1996"},{"key":"b33","series-title":"J Virol","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1128\/JVI.75.3.1476-1486.2001","article-title":"Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial 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ependymomas.","volume":"10","author":"Weggen","year":"2000"}],"container-title":["Journal of Neurosurgery: 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