{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:46:42Z","timestamp":1790642802605,"version":"4.1.0"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8]]},"abstract":"\n \n Object<\/jats:italic>\n <\/jats:title>\n In recent years, comparisons between intracranial volumes (ICVs) in patients with craniosynostosis and healthy patients have given variable results, leading to questions regarding the validity of the normal reference material and the comparability of the measurement techniques. In this study, ICVs in patients with nonsyndromal craniosynostosis without previous surgical intervention were compared with the ICVs of a normal population of European descent determined using the same method for each group.<\/jats:p>\n <\/jats:sec>\n \n \n Methods<\/jats:italic>\n <\/jats:title>\n Determination of ICV was based on measuring the area of intersection in each computerized tomography slice. For comparisons the ICV measurements for each patient were standardized with regard to age and sex by expressing them in terms of the standard deviation score.<\/jats:p>\n Only the group of boys with metopic synostosis had a tendency toward smaller ICV than did healthy boys (p = 0.04). Partitioning the male metopic data into age groups younger and older than 7 months of age revealed that the younger children had normal ICVs, whereas the older children had, on average, smaller ICVs (p = 0.02). Both the female sagittal synostosis and the male unilateral coronal synostosis groups had larger than normal ICVs, both with a probability value less than 0.001.<\/jats:p>\n <\/jats:sec>\n \n \n Conclusions<\/jats:italic>\n <\/jats:title>\n No evidence was found that the ICVs of patients with nonsyndromal craniosynostosis are smaller than those of normal children, except for boys older than 7 months of age with metopic synostosis. This finding may have implications for the timing of surgical intervention for these patients. The indications are that interventions should be focused less on ICV and more on normalizing craniofacial shape and promoting normal development.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/ped.2005.103.2.0137","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T06:00:46Z","timestamp":1282888846000},"page":"137-141","source":"Crossref","is-referenced-by-count":12,"title":["Intracranial volume in patients with nonsyndromal craniosynostosis"],"prefix":"10.3171","volume":"103","author":[{"given":"David John","family":"Netherway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Helen","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter John","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David John","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/00001665-200011030-00002","article-title":"CT-determined intracranial volume for a normal population.","volume":"11","author":"Abbott","year":"2000"},{"key":"b2","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1097\/00001665-200411000-00024","article-title":"Intracranial volume measurement of metopic craniosynostosis.","volume":"15","author":"Anderson","year":"2004"},{"key":"b3","series-title":"Craniosynostosis: Diagnosis, Evaluation, and Management","first-page":"112","article-title":"Epidemiology of craniosynostosis","author":"Cohen","year":"2000"},{"key":"b4","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00001665-199001000-00003","article-title":"Intracranial volume in children with craniosynostosis.","volume":"1","author":"Gault","year":"1990"},{"key":"b5","series-title":"Th\u00e8se pour le Doctorant en M\u00e9decine. Radiographie du Crane de 226 Enfants Normaux de la Naissance a 8 Ans: Impressions Digitiformes, Capacit\u00e9, Angles et Indices.","author":"Litchtenberg","year":"1960"},{"key":"b6","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/00006534-199508000-00008","article-title":"Metopic and sagittal synostosis: intracranial volume measurements prior to and after cranio-orbital reshaping in childhood.","volume":"96","author":"Marsh","year":"1995"},{"key":"b7","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/00001665-199809000-00003","article-title":"Bilambdoid and posterior sagittal synostosis: the Mercedes Benz syndrome.","volume":"9","author":"Moore","year":"1998"},{"key":"b8","series-title":"Transactions 9th International Congress on Cleft Palate and Related Craniofacial Anomalies.","first-page":"591","article-title":"Intracranial volume of patients with craniosynostosis","author":"Netherway","year":"2001"},{"key":"b9","series-title":"Asian J Surg","first-page":"68","article-title":"Intracranial volume measurement for craniofacial surgery.","volume":"20","author":"Netherway","year":"1997"},{"key":"b10","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/00006534-199508000-00007","article-title":"Metopic and sagittal synostosis: intracranial volume measurements prior to and after cranio-orbital reshaping in childhood.","volume":"96","author":"Posnick","year":"1995"},{"key":"b11","series-title":"Handbook of Nonlinear Regression Models.","author":"Ratowski","year":"1990"},{"key":"b1","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/00001665-200011030-00002","article-title":"CT-determined intracranial volume for a normal population.","volume":"11","author":"Abbott","year":"2000"},{"key":"b2","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1097\/00001665-200411000-00024","article-title":"Intracranial volume measurement of metopic craniosynostosis.","volume":"15","author":"Anderson","year":"2004"},{"key":"b3","series-title":"Craniosynostosis: Diagnosis, Evaluation, and Management","first-page":"112","article-title":"Epidemiology of craniosynostosis","author":"Cohen","year":"2000"},{"key":"b4","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00001665-199001000-00003","article-title":"Intracranial volume in children with craniosynostosis.","volume":"1","author":"Gault","year":"1990"},{"key":"b5","series-title":"Th\u00e8se pour le Doctorant en M\u00e9decine. Radiographie du Crane de 226 Enfants Normaux de la Naissance a 8 Ans: Impressions Digitiformes, Capacit\u00e9, Angles et Indices.","author":"Litchtenberg","year":"1960"},{"key":"b6","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/00006534-199508000-00008","article-title":"Metopic and sagittal synostosis: intracranial volume measurements prior to and after cranio-orbital reshaping in childhood.","volume":"96","author":"Marsh","year":"1995"},{"key":"b7","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/00001665-199809000-00003","article-title":"Bilambdoid and posterior sagittal synostosis: the Mercedes Benz syndrome.","volume":"9","author":"Moore","year":"1998"},{"key":"b8","series-title":"Transactions 9th International Congress on Cleft Palate and Related Craniofacial Anomalies.","first-page":"591","article-title":"Intracranial volume of patients with craniosynostosis","author":"Netherway","year":"2001"},{"key":"b9","series-title":"Asian J Surg","first-page":"68","article-title":"Intracranial volume measurement for craniofacial surgery.","volume":"20","author":"Netherway","year":"1997"},{"key":"b10","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/00006534-199508000-00007","article-title":"Metopic and sagittal synostosis: intracranial volume measurements prior to and after cranio-orbital reshaping in childhood.","volume":"96","author":"Posnick","year":"1995"},{"key":"b11","series-title":"Handbook of Nonlinear Regression Models.","author":"Ratowski","year":"1990"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/103\/2\/article-p137.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/103\/2\/article-p137.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/103\/2\/article-p137.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:19:54Z","timestamp":1782209994000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/103\/2\/article-p137.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":22,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/ped.2005.103.2.0137","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}