{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:49:29Z","timestamp":1782211769021,"version":"3.54.5"},"reference-count":46,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>\u2713The authors describe the first documented case of transplacental transmission of metastatic melanoma to the neuraxis. The patient was a 7-month-old boy who presented with signs and symptoms of elevated intracranial pressure. Magnetic resonance imaging revealed an inhomogeneously enhancing posterior fossa mass measuring 5 \u00d7 5 \u00d7 6 cm and filling the fourth ventricle. A posterior fossa craniotomy was performed. Pathological studies confirmed the presence of a metastatic melanoma that was pathologically identical to that of his mother. The boy received aggressive chemotherapy and underwent an additional resection. He also required a ventriculoperitoneal shunt for treatment of his hydrocephalus. He lived longer than any other patient with transplacental transmission of metastatic melanoma but ultimately died of the disease, 18 months after his initial presentation.<\/jats:p>","DOI":"10.3171\/ped.2005.103.2.0191","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T06:00:46Z","timestamp":1282888846000},"page":"191-193","source":"Crossref","is-referenced-by-count":4,"title":["Transplacental transmission of metastatic melanoma to the posterior fossa"],"prefix":"10.3171","volume":"103","author":[{"given":"Eric R.","family":"Trumble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Pearl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/S0190-9622(03)00124-5","article-title":"Placental metastasis of maternal melanoma.","volume":"49","author":"Altman","year":"2003"},{"key":"b2","series-title":"Pediatr Pathol","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/15513818909022330","article-title":"Maternal malignant melanoma with placental metastasis: a case report with literature review.","volume":"9","author":"Anderson","year":"1989"},{"key":"b3","series-title":"Acta Paediatr","first-page":"123","article-title":"A case of transplacental tumor metastasis.","volume":"52","author":"Aronsson","year":"1963"},{"key":"b4","series-title":"Melanoma Res","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/01.cmr.0000136707.60108.ab","article-title":"The effect of temozolomidebased chemotherapy in patients with cerebral metastases from melanoma.","volume":"14","author":"Bafaloukos","year":"2004"},{"key":"b5","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1002\/1097-0142(196508)18:8<1048::AID-CNCR2820180817>3.0.CO;2-V","article-title":"Metastatic malignant melanoma from mother to fetus.","volume":"18","author":"Brodsky","year":"1965"},{"key":"b6","series-title":"Acta Paediatr","first-page":"37","article-title":"Transplacental metastasis of malignant melanoma. 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