{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:49:04Z","timestamp":1782211744356,"version":"3.54.5"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:sec id=\"S1\">\n                    <jats:title>\n                      <jats:italic>Object<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>This study was performed to optimize the management of craniopharyngiomas, particularly by identifying factors predicting weight changes to prevent obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2\">\n                    <jats:title>\n                      <jats:italic>Methods<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>A series of 35 patients who had undergone surgery at a mean age of 7.4 \u00b1 3.7 years (standard deviation [SD]) and had been followed up until 14.9 \u00b1 5 years of age by the same endocrinologist were assigned to one of three groups according to their hypothalamic involvement: Group 1 (10 patients) had no involvement, Group 2 (eight patients) had compression without involvement, and Group 3 (17 patients) had severe involvement.<\/jats:p>\n                    <jats:p>Abnormal height and\/or weight evolution indicated the craniopharyngioma in only 17% of the patients, although these elements were present at diagnosis in 85%. Before surgery, 85% of the patients lacked growth hormone, 24% lacked thyroid-stimulating hormone, 15% lacked adrenocorticotropin hormone, and 12% lacked antidiuretic hormone. All had complete hypothalamic\u2014pituitary deficiencies after surgery.<\/jats:p>\n                    <jats:p>The body mass index (BMI) before surgery (mean SD 1.1 \u00b1 1.6) was positively correlated with BMI 1 year after surgery (mean SD 3.1 \u00b1 2), which correlated with the BMI at the last evaluation (mean SD 3.1 \u00b1 1.9; p &lt; 0.0001 for both). Before surgery, patients in Group 3 had a greater BMI than did Group 1 (p &lt; 0.02). The BMI of Group 1 patients did not change, but those of Groups 2 and 3 patients increased during the 1st year after surgery (p &lt; 0.02 and p = 0.0003, respectively), with no further change. The changes occurred mainly during the first 3 months after surgery in Group 1, during the first 6 months in Group 2, and throughout the year in Group 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S3\">\n                    <jats:title>\n                      <jats:italic>Conclusions<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>The degree of hypothalamic involvement by the craniopharyngioma determines the presentation and predicts weight changes after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/ped.2005.103.5.0421","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T06:01:51Z","timestamp":1282888911000},"page":"421-426","source":"Crossref","is-referenced-by-count":7,"title":["Influence of tumor location on the presentation and evolution of craniopharyngiomas"],"prefix":"10.3171","volume":"103","author":[{"given":"St\u00e9phanie","family":"Meuric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Brauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Trivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Souberbielle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Zerah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sainte-Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","first-page":"547","article-title":"The descriptive epidemiology of 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activity.","volume":"88","author":"Harz","year":"2003"},{"key":"b5","series-title":"Horm Res","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000185531","article-title":"Growth before and during growth hormone treatment in children operated for craniopharyngioma.","volume":"48","author":"Hogeveen","year":"1997"},{"key":"b6","series-title":"Endocrinology","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1210\/endo-100-1-108","article-title":"The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity.","volume":"100","author":"Inoue","year":"1977"},{"key":"b7","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1210\/jcem.84.12.6215","article-title":"Pituitary tumors in children and adolescents.","volume":"84","author":"Lafferty","year":"1999"},{"key":"b8","series-title":"J Clin Endocrinol 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pr\u00e9 et postop\u00e9ratoire.","volume":"155","author":"Recasens","year":"1997"},{"key":"b12","series-title":"Eur J Clin Nutr","first-page":"13","article-title":"Body mass index variations: centiles from birth to 87 years.","volume":"45","author":"Rolland-Cachera","year":"1991"},{"key":"b13","series-title":"J Clin Endocrinol Metab","first-page":"374","article-title":"Replacement of growth hormone (GH) in normally growing GH-deficient patients operated for craniopharyngioma.","volume":"80","author":"Schoenle","year":"1995"},{"key":"b14","series-title":"Auxologie, M\u00e9thode et S\u00e9quences.","author":"Semp\u00e9","year":"1979"},{"key":"b15","series-title":"Acta Paediatr Scand","first-page":"587","article-title":"Children with craniopharyngioma. 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