{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:18:38Z","timestamp":1768310318824,"version":"3.49.0"},"reference-count":48,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>In this study, the authors report their experience with the surgical treatment of intracranial teratomas with an emphasis on the indications for delayed resection after oncological treatment.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors retrospectively reviewed the cases of 14 children with intracranial teratomas. The mean age at diagnosis was 10.5 years (range 2 days\u201318 years), and 11 patients were male. The final histological analysis revealed pure mature teratoma in 5 cases, mixed teratoma with germinoma in 3 cases, and nongerminomatous malignant germ cell tumor in 6 cases. Thirteen patients underwent tumor resection, and these patients were divided into 2 subgroups according to the timing of surgery. In Group A, 10 patients underwent resection as the primary treatment because no tumor markers were detected in 4 patients, a teratomatous component was revealed on biopsy sampling in 3 patients, and a large tumor volume in 3 patients. In Group B, 3 patients underwent removal of residual pure mature teratoma after oncological treatment.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Seven of the 8 patients (87.5%) with pure mature teratomas or with mixed teratoma and germinoma are currently alive (mean follow-up of 9 years); the eighth patient died of postoperative meningitis. Two of the 6 patients (33%) with mixed nongerminomatous malignant germ cell tumors died of tumor progression regardless of the timing of surgery.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The results of this study support the belief that microsurgical removal is the only effective treatment for intracranial teratomas. Surgery may be performed as the primary therapy when there is evidence of a noninvasive teratoma, and as a secondary therapy if there is only a partial response to neoadjuvant therapy or if progression is observed in mixed malignant germ cell tumors.<\/jats:p><\/jats:sec>","DOI":"10.3171\/ped.2008.2.11.331","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T18:59:56Z","timestamp":1225479596000},"page":"331-338","source":"Crossref","is-referenced-by-count":36,"title":["Intracranial teratomas in children: the role and timing of surgical removal"],"prefix":"10.3171","volume":"2","author":[{"given":"R\u00e9my","family":"Noudel","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Maison Blanche Hospital, University of Reims; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Vinchon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Roger Salengro Hospital, University of Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Dhellemmes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Roger Salengro Hospital, University of Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude Fabien","family":"Litr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Maison Blanche Hospital, University of Reims; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Rousseaux","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Maison Blanche Hospital, University of Reims; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0020331","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1002\/1097-0142(19940815)74:4<1329::AID-CNCR2820740424>3.0.CO;2-L","article-title":"Resection of postchemotherapy residual masses and limited retroperitoneal lymphadenectomy in patients with metastatic nonseminomatous germ cell tumors","volume":"74","author":"Aprikian","year":"1994"},{"key":"b2-0020331","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1023\/A:1005863601481","article-title":"An attempt to treat pediatric intracranial \u03b1 FP and \u03b2HCG secreting germ cell tumors with chemotherapy alone. 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