{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:42:51Z","timestamp":1791812571842,"version":"4.3.4"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:sec>\n<jats:title>Object.<\/jats:title>\n<jats:p>The authors report data concerning the safety, effectiveness, and patterns of failure obtained in a Phase I\/II study of stereotactic body radiotherapy (SBRT) for spinal metastatic tumors.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods.<\/jats:title>\n<jats:p>Sixty-three cancer patients underwent near-simultaneous computed tomography\u2013guided SBRT. Spinal magnetic resonance imaging was conducted at baseline and at each follow-up visit. The National Cancer Institute Common Toxicity Criteria 2.0 assessments were used to evaluate toxicity.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results.<\/jats:title>\n<jats:p>The median tumor volume of 74 spinal metastatic lesions was 37.4 cm<jats:sup>3<\/jats:sup> (range 1.6\u2013358 cm<jats:sup>3<\/jats:sup>). No neuropathy or myelopathy was observed during a median follow-up period of 21.3 months (range 0.9\u201349.6 months). The actuarial 1-year tumor progression\u2013free incidence was 84% for all tumors. Pattern-of-failure analysis showed two primary mechanisms of failure: 1) recurrence in the bone adjacent to the site of previous treatment, and 2) recurrence in the epidural space adjacent to the spinal cord. Grade 3 or 4 toxicities were limited to acute Grade 3 nausea, vomiting, and diarrhea (one case); Grade 3 dysphagia and trismus (one case); and Grade 3 noncardiac chest pain (one case). There was no subacute or late Grade 3 or 4 toxicity.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions.<\/jats:title>\n<jats:p>Analysis of the data obtained in the present study supports the safety and effectiveness of SBRT in cases of spinal metastatic cancer. The authors consider it prudent to routinely treat the pedicles and posterior elements using a wide bone margin posterior to the diseased vertebrae because of the possible direct extension into these structures. 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